Protein: P00546

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P00546 (Uniprot) CDK1_YEAST CDC28 Cyclin-dependent kinase 1 yeast No
Uniprot: This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 1018, 1120, 1135, 1250, 1315 GO:0016192 vesicle-mediated transport 1134 2.99e-34 2.53e-55
GO:0044260 cellular macromolecule metabolic process 1018, 1120, 1135, 1250, 1315 GO:0015833 peptide transport 1349 2.96e-17 2.61e-40
GO:0006139 nucleobase-containing compound metabolic process 1078, 1092 GO:0016192 vesicle-mediated transport 1134 1.23e-52 1.21e-92
GO:0016192 vesicle-mediated transport 1134 GO:0043170 macromolecule metabolic process 1219 2.97e-38 6.12e-72
GO:0009059 macromolecule biosynthetic process 1198 GO:0015833 peptide transport 1349 5.69e-13 2.89e-52
GO:0043170 macromolecule metabolic process 1219 GO:0015833 peptide transport 1349 3.85e-11 1.47e-03
GO:0006810 transport 1349 GO:0007049 cell cycle 1372 7.35e-08 6.07e-45
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
906 GO:0022402 cell cycle process
951 GO:0010467 gene expression
951 GO:0018193 peptidyl-amino acid modification
1018 GO:0016070 RNA metabolic process
1018 GO:0010468 regulation of gene expression
1068 GO:0022607 cellular component assembly
1078 GO:0090304 nucleic acid metabolic process
1078 GO:0060255 regulation of macromolecule metabolic process
1092 GO:0090304 nucleic acid metabolic process
1093 GO:0022607 cellular component assembly
1096 GO:0051276 chromosome organization
1096 GO:0007059 chromosome segregation
1096 GO:1903047 mitotic cell cycle process
1096 GO:0000280 nuclear division
1120 GO:0006259 DNA metabolic process
1120 GO:0016070 RNA metabolic process
1120 GO:0034645 cellular macromolecule biosynthetic process
1120 GO:0010467 gene expression
1134 GO:0048193 Golgi vesicle transport
1134 GO:0022607 cellular component assembly
1134 GO:0034613 cellular protein localization
1134 GO:0051649 establishment of localization in cell
1134 GO:0043933 macromolecular complex subunit organization
1134 GO:0015031 protein transport
1135 GO:0016070 RNA metabolic process
1135 GO:0010467 gene expression
1191 GO:0090304 nucleic acid metabolic process
1197 GO:0006261 DNA-dependent DNA replication
1197 GO:0016070 RNA metabolic process
1197 GO:0006278 RNA-dependent DNA biosynthetic process
1197 GO:0006302 double-strand break repair
1198 GO:0034645 cellular macromolecule biosynthetic process
1198 GO:0006464 cellular protein modification process
1198 GO:0090304 nucleic acid metabolic process
1198 GO:0060255 regulation of macromolecule metabolic process
1198 GO:0019219 regulation of nucleobase-containing compound metabolic process
1219 GO:0010467 gene expression
1250 GO:0016070 RNA metabolic process
1250 GO:0010629 negative regulation of gene expression
1302 GO:0044772 mitotic cell cycle phase transition
1302 GO:0090304 nucleic acid metabolic process
1302 GO:0051726 regulation of cell cycle
1302 GO:2000112 regulation of cellular macromolecule biosynthetic process
1302 GO:0019219 regulation of nucleobase-containing compound metabolic process
1302 GO:0033043 regulation of organelle organization
1315 GO:0016070 RNA metabolic process
1315 GO:0010468 regulation of gene expression
1349 GO:0046907 intracellular transport
1349 GO:0051640 organelle localization
1349 GO:0015031 protein transport
1349 GO:0016192 vesicle-mediated transport
1361 GO:0090304 nucleic acid metabolic process
1372 GO:0022402 cell cycle process
1372 GO:0034622 cellular macromolecular complex assembly
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
906 GO:0005634 nucleus
913 GO:0005634 nucleus
951 GO:0070013 intracellular organelle lumen
951 GO:0005634 nucleus
958 GO:0005935 cellular bud neck
980 GO:0005634 nucleus
1018 GO:0043232 intracellular non-membrane-bounded organelle
1018 GO:0005634 nucleus
1039 GO:0005634 nucleus
1078 GO:0005634 nucleus
1092 GO:0005634 nucleus
1093 GO:0043232 intracellular non-membrane-bounded organelle
1096 GO:0043232 intracellular non-membrane-bounded organelle
1096 GO:0031981 nuclear lumen
1114 GO:0005634 nucleus
1120 GO:0005634 nucleus
1134 GO:0005783 endoplasmic reticulum
1135 GO:0005634 nucleus
1191 GO:0043232 intracellular non-membrane-bounded organelle
1191 GO:0005634 nucleus
1197 GO:0043232 intracellular non-membrane-bounded organelle
1197 GO:0005634 nucleus
1197 GO:0061695 transferase complex, transferring phosphorus-containing groups
1198 GO:0043232 intracellular non-membrane-bounded organelle
1198 GO:0005634 nucleus
1211 GO:0005634 nucleus
1250 GO:0043232 intracellular non-membrane-bounded organelle
1250 GO:0005634 nucleus
1302 GO:0005634 nucleus
1315 GO:0005634 nucleus
1349 GO:0005783 endoplasmic reticulum
1361 GO:0044427 chromosomal part
1361 GO:0031981 nuclear lumen
1372 GO:0044430 cytoskeletal part
1372 GO:0015630 microtubule cytoskeleton
1372 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000706 meiotic DNA double-strand break processing IGI
GO:0006370 7-methylguanosine mRNA capping IMP
GO:0007070 negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle IMP
GO:0007130 synaptonemal complex assembly IMP
GO:0008284 positive regulation of cell proliferation IEA
GO:0008356 asymmetric cell division IEA
GO:0009409 response to cold IEA
GO:0010568 regulation of budding cell apical bud growth IMP
GO:0010569 regulation of double-strand break repair via homologous recombination IMP
GO:0010570 regulation of filamentous growth IMP
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP
GO:0010696 positive regulation of spindle pole body separation IMP
GO:0010898 positive regulation of triglyceride catabolic process IMP
GO:0016192 vesicle-mediated transport IMP
GO:0016572 histone phosphorylation IBA
GO:0018105 peptidyl-serine phosphorylation IDA
GO:0018107 peptidyl-threonine phosphorylation IMP
GO:0030154 cell differentiation IBA
GO:0032210 regulation of telomere maintenance via telomerase IGI
GO:0034504 protein localization to nucleus IMP
GO:0040020 regulation of meiotic nuclear division IEA
GO:0042023 DNA endoreduplication IEA
GO:0044772 mitotic cell cycle phase transition IBA
GO:0045819 positive regulation of glycogen catabolic process IMP
GO:0045875 negative regulation of sister chromatid cohesion IMP
GO:0045892 negative regulation of transcription, DNA-templated IMP
GO:0045893 positive regulation of transcription, DNA-templated IGI
GO:0045930 negative regulation of mitotic cell cycle IDA
GO:0045931 positive regulation of mitotic cell cycle IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0051446 positive regulation of meiotic cell cycle IMP
GO:0051447 negative regulation of meiotic cell cycle IMP
GO:0060303 regulation of nucleosome density IMP
GO:0070816 phosphorylation of RNA polymerase II C-terminal domain IDA
GO:0090169 regulation of spindle assembly IMP
GO:0098725 symmetric cell division IEA
GO:1901319 positive regulation of trehalose catabolic process IMP
GO:1902002 protein phosphorylation involved in cellular protein catabolic process IGI
GO:1902806 regulation of cell cycle G1/S phase transition IEA
GO:1905634 regulation of protein localization to chromatin IDA
GO:1990139 protein localization to nuclear periphery IMP
GO:1990758 mitotic sister chromatid biorientation IGI
GO:1990801 protein phosphorylation involved in mitotic spindle assembly IGI
GO:1990802 protein phosphorylation involved in DNA double-strand break processing IMP
GO:1990803 protein phosphorylation involved in protein localization to spindle microtubule IMP
GO:1990804 protein phosphorylation involved in double-strand break repair via nonhomologous end joining IMP
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000235 astral microtubule IDA
GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005783 endoplasmic reticulum IDA
GO:0005816 spindle pole body IDA
GO:0005829 cytosol IEA
GO:0005886 plasma membrane IEA
GO:0005935 cellular bud neck IDA
GO:0010005 cortical microtubule, transverse to long axis IEA
GO:0010494 cytoplasmic stress granule IDA
GO:0072686 mitotic spindle IBA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005737 cytoplasm 5.14e-51 7.30e-86
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 3.41e-68 1.61e-241
GO:0005634 nucleus GO:0005886 plasma membrane 2.94e-56 3.82e-107
GO:0005783 endoplasmic reticulum GO:0005829 cytosol 3.32e-08 1.60e-37
Interactor Also a MoonDB EMF protein
MYO3_YEAST Yes: P36006 (MoonDB)
JSN1_YEAST Yes: P47135 (MoonDB)
SFB3_YEAST No
2A5D_YEAST No
ACE2_YEAST No
ACF4_YEAST No
ACM1_YEAST No
ADY3_YEAST No
ALY2_YEAST No
ASE1_YEAST No
ASH1_YEAST No
ASSY_YEAST No
ATC4_YEAST No
ATG20_YEAST No
ATG41_YEAST No
AXL2_YEAST No
BBP1_YEAST No
BCK2_YEAST No
BEM1_YEAST No
BEM3_YEAST No
BNA3_YEAST No
BNI1_YEAST No
BOP3_YEAST No
BSP1_YEAST No
BUD3_YEAST No
BUD4_YEAST No
BUD6_YEAST No
CA120_YEAST No
CAK1_YEAST No
CDC20_YEAST No
CDC5_YEAST No
CDH1_YEAST No
CG11_YEAST No
CG13_YEAST No
CHS2_YEAST No
CKS1_YEAST No
CNN1_YEAST No
CRF1_YEAST No
CSR2_YEAST No
CST9_YEAST No
CYC2_YEAST No
DAL81_YEAST No
DBF20_YEAST No
DBF2_YEAST No
DBF4_YEAST Yes: P32325 (MoonDB)
DDC1_YEAST No
DNA2_YEAST No
DPB2_YEAST No
DPOA_YEAST No
DUS3_YEAST No
ECO1_YEAST No
ELM1_YEAST No
EXO84_YEAST No
FAR10_YEAST No
FAR1_YEAST No
FIN1_YEAST No
FIR1_YEAST No
FKH2_YEAST No
FMT_YEAST No
FPK1_YEAST No
FUN30_YEAST No
FUS1_YEAST No
GAC1_YEAST No
GIN4_YEAST No
GIP4_YEAST No
HCM1_YEAST No
HOS4_YEAST No
HPH2_YEAST No
IFH1_YEAST No
INO2_YEAST No
IPL1_YEAST No
KAR3_YEAST No
KEL1_YEAST No
KEL2_YEAST No
KIN2_YEAST No
KIP2_YEAST No
KIP3_YEAST No
KPC1_YEAST No
LRE1_YEAST No
LRS4_YEAST No
LTE1_YEAST No
MCM3_YEAST No
MLH2_YEAST No
MLP1_YEAST No
MMR1_YEAST No
MMS4_YEAST No
MOB1_YEAST No
MON1_YEAST No
MPC54_YEAST No
MPIP_YEAST No
MPS2_YEAST No
MPT5_YEAST No
MSA1_YEAST No
MSA2_YEAST No
MSB1_YEAST No
MSB2_YEAST No
MSC3_YEAST No
MSH6_YEAST No
MUK1_YEAST No
NBA1_YEAST No
NBP1_YEAST No
NDD1_YEAST No
NET1_YEAST No
NUP1_YEAST No
NUP60_YEAST No
NUR1_YEAST No
ORC1_YEAST No
ORC2_YEAST No
ORC6_YEAST No
PAL1_YEAST No
PCL6_YEAST No
PCL7_YEAST No
PHD1_YEAST No
PHO2_YEAST No
PIN2_YEAST No
PKH2_YEAST No
PLM2_YEAST No
PO152_YEAST No
POG1_YEAST No
PRR1_YEAST No
PTK2_YEAST No
PXL1_YEAST No
RAD9_YEAST No
RAV1_YEAST No
RBS1_YEAST No
RCC1_YEAST No
RGA1_YEAST No
RGA2_YEAST No
RLF2_YEAST No
RRP6_YEAST No
RTK1_YEAST No
SAC7_YEAST No
SAK1_YEAST No
SEC3_YEAST No
SECU_YEAST No
SEN1_YEAST No
SFG1_YEAST No
SFI1_YEAST No
SIC1_YEAST No
SIP3_YEAST No
SIR4_YEAST No
SIT1_YEAST No
SKG3_YEAST No
SKG6_YEAST No
SLD2_YEAST No
SLK19_YEAST No
SMC4_YEAST No
SP110_YEAST No
SPA2_YEAST No
SPO11_YEAST No
SRC1_YEAST No
SRL3_YEAST No
SRS2_YEAST No
SSK1_YEAST No
STB1_YEAST No
STU2_YEAST No
SWE1_YEAST No
SWI5_YEAST No
SWI6_YEAST No
T2FA_YEAST No
TAF4_YEAST No
TBP7_YEAST No
TDA11_YEAST No
TGL4_YEAST No
TGL5_YEAST No
TOS2_YEAST No
TOS4_YEAST No
TREA_YEAST No
TUS1_YEAST No
UFE1_YEAST Yes: P41834 (MoonDB)
ULP2_YEAST No
URB1_YEAST No
VMR1_YEAST No
VNX1_YEAST No
VPS54_YEAST No
WHI5_YEAST No
XBP1_YEAST No
YBY8_YEAST No
YEN1_YEAST No
YEY8_YEAST No
YG1O_YEAST No
YGY5_YEAST No
YHF0_YEAST No
YJ24_YEAST No
YK58_YEAST No
YL278_YEAST No
YML9_YEAST No
YNF8_YEAST No
YO036_YEAST No
YOX1_YEAST No
YP014_YEAST No
YP174_YEAST No
YRF13_YEAST No
YRF16_YEAST No
ZIP1_YEAST No
PMID Article Title
6361575 Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes.
7597849 Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28.
7813418 Complete DNA sequence of yeast chromosome II.
14562106 Global analysis of protein expression in yeast.
14574415 Targets of the cyclin-dependent kinase Cdk1.
15665377 Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
TVBY8 A00657 PIR
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase PF00069 Pfam
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM