Protein: P00546 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P00546 (Uniprot)	CDK1_YEAST	CDC28	Cyclin-dependent kinase 1	yeast	No

Protein Function

Uniprot: This protein is essential for the completion of the start, the controlling event, in the cell cycle. More than 200 substrates have been identified.

MoonDB Dissimilar Functions

Showing 1 to 7 of 7 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	1078, 1092	GO:0016192	vesicle-mediated transport	1134	1.23e-52	1.21e-92
GO:0006810	transport	1349	GO:0007049	cell cycle	1372	7.35e-08	6.07e-45
GO:0009059	macromolecule biosynthetic process	1198	GO:0015833	peptide transport	1349	5.69e-13	2.89e-52
GO:0016192	vesicle-mediated transport	1134	GO:0043170	macromolecule metabolic process	1219	2.97e-38	6.12e-72
GO:0043170	macromolecule metabolic process	1219	GO:0015833	peptide transport	1349	3.85e-11	1.47e-03
GO:0044260	cellular macromolecule metabolic process	1018, 1120, 1135, 1250, 1315	GO:0016192	vesicle-mediated transport	1134	2.99e-34	2.53e-55
GO:0044260	cellular macromolecule metabolic process	1018, 1120, 1135, 1250, 1315	GO:0015833	peptide transport	1349	2.96e-17	2.61e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 54 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
906	GO:0022402	cell cycle process
951	GO:0010467	gene expression
951	GO:0018193	peptidyl-amino acid modification
1018	GO:0016070	RNA metabolic process
1018	GO:0010468	regulation of gene expression
1068	GO:0022607	cellular component assembly
1078	GO:0090304	nucleic acid metabolic process
1078	GO:0060255	regulation of macromolecule metabolic process
1092	GO:0090304	nucleic acid metabolic process
1093	GO:0022607	cellular component assembly

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Cellular Components

Showing 1 to 10 of 36 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
906	GO:0005634	nucleus
913	GO:0005634	nucleus
951	GO:0070013	intracellular organelle lumen
951	GO:0005634	nucleus
958	GO:0005935	cellular bud neck
980	GO:0005634	nucleus
1018	GO:0043232	intracellular non-membrane-bounded organelle
1018	GO:0005634	nucleus
1039	GO:0005634	nucleus
1078	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 47 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000706	meiotic DNA double-strand break processing	IGI
GO:0006370	7-methylguanosine mRNA capping	IMP
GO:0007070	negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle	IMP
GO:0007130	synaptonemal complex assembly	IMP
GO:0008284	positive regulation of cell proliferation	IEA
GO:0008356	asymmetric cell division	IEA
GO:0009409	response to cold	IEA
GO:0010568	regulation of budding cell apical bud growth	IMP
GO:0010569	regulation of double-strand break repair via homologous recombination	IMP
GO:0010570	regulation of filamentous growth	IMP

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Cellular Components

Showing 1 to 10 of 12 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000235	astral microtubule	IDA
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005816	spindle pole body	IDA
GO:0005829	cytosol	IEA
GO:0005886	plasma membrane	IEA
GO:0005935	cellular bud neck	IDA
GO:0010005	cortical microtubule, transverse to long axis	IEA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 4 of 4 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	3.41e-68	1.61e-241
GO:0005634	nucleus	GO:0005886	plasma membrane	2.94e-56	3.82e-107
GO:0005783	endoplasmic reticulum	GO:0005829	cytosol	3.32e-08	1.60e-37

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All Protein Interactions

Showing 1 to 10 of 195 entries

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Interactor	Also a MoonDB EMF protein
2A5D_YEAST	No
ACE2_YEAST	No
ACF4_YEAST	No
ACM1_YEAST	No
ADY3_YEAST	No
ALY2_YEAST	No
ASE1_YEAST	No
ASH1_YEAST	No
ASSY_YEAST	No
ATC4_YEAST	No

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Publications Associated

Showing 1 to 10 of 10 entries

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PMID	Article Title
6361575	Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes.
7597849	Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28.
7813418	Complete DNA sequence of yeast chromosome II.
14562106	Global analysis of protein expression in yeast.
14574415	Targets of the cyclin-dependent kinase Cdk1.
15665377	Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.
17330950	Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
19779198	Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
22814378	N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
Kinase-like_dom_sf	IPR011009	InterPro
Pkinase	PF00069	Pfam
Prot_kinase_dom	IPR000719	InterPro
PROTEIN_KINASE_ATP	PS00107	PROSITE
Protein_kinase_ATP_BS	IPR017441	InterPro
PROTEIN_KINASE_DOM	PS50011	PROSITE
PROTEIN_KINASE_ST	PS00108	PROSITE
S_TKc	SM00220	SMART
Ser/Thr_kinase_AS	IPR008271	InterPro
SSF56112	SSF56112	SUPFAM

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