Protein: Q04439

Uniprot: One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 992 GO:0097435 supramolecular fiber organization 1177, 1242 4.36e-08 1.57e-47
GO:0097435 supramolecular fiber organization 1177, 1242 GO:0006725 cellular aromatic compound metabolic process 933 4.17e-09 4.54e-39
GO:0097435 supramolecular fiber organization 1177, 1242 GO:0044260 cellular macromolecule metabolic process 1311 6.22e-07 4.50e-41
Module ID (MoonGO) GO ID (BP) GO Name
933 GO:0010467 gene expression
933 GO:0006139 nucleobase-containing compound metabolic process
934 GO:0016310 phosphorylation
992 GO:0010467 gene expression
1017 GO:0034314 Arp2/3 complex-mediated actin nucleation
1019 GO:0034314 Arp2/3 complex-mediated actin nucleation
1055 GO:0007010 cytoskeleton organization
1177 GO:0007015 actin filament organization
1177 GO:0022607 cellular component assembly
1177 GO:0044087 regulation of cellular component biogenesis
1177 GO:0033043 regulation of organelle organization
1242 GO:0051666 actin cortical patch localization
1242 GO:0007015 actin filament organization
1242 GO:0034622 cellular macromolecular complex assembly
1242 GO:0006897 endocytosis
1242 GO:1903047 mitotic cell cycle process
1242 GO:0032505 reproduction of a single-celled organism
1311 GO:0016070 RNA metabolic process
1311 GO:0010467 gene expression
1311 GO:0031326 regulation of cellular biosynthetic process
Module ID (MoonGO) GO ID (CC) GO Name
884 GO:0043232 intracellular non-membrane-bounded organelle
933 GO:0005634 nucleus
948 GO:0043232 intracellular non-membrane-bounded organelle
954 GO:0043232 intracellular non-membrane-bounded organelle
992 GO:0005634 nucleus
1017 GO:0030479 actin cortical patch
1019 GO:0030479 actin cortical patch
1055 GO:0043232 intracellular non-membrane-bounded organelle
1069 GO:0043232 intracellular non-membrane-bounded organelle
1069 GO:0005634 nucleus
1165 GO:0016021 integral component of membrane
1177 GO:0005856 cytoskeleton
1177 GO:0005634 nucleus
1242 GO:0030479 actin cortical patch
1311 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006887 exocytosis TAS
GO:0006897 endocytosis IMP
GO:0006898 receptor-mediated endocytosis IMP
GO:0006970 response to osmotic stress TAS
GO:0007121 bipolar cellular bud site selection TAS
GO:0009651 response to salt stress IPI
GO:0031505 fungal-type cell wall organization TAS
GO:0051666 actin cortical patch localization IMP
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0016459 myosin complex IEA
GO:0030479 actin cortical patch IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8614799 Role of type I myosins in receptor-mediated endocytosis in yeast.
8682864 Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.
9169872 The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9628892 The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization.
10648568 A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.
10648569 Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
10944111 An intact SH3 domain is required for myosin I-induced actin polymerization.
11901111 The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae.
12391157 Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
12725728 The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.
12808026 She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae.
14562106 Global analysis of protein expression in yeast.
16478726 TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p.
17287358 Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
17522383 Interaction of the endocytic scaffold protein Pan1 with the type I myosins contributes to the late stages of endocytosis.
18407956 A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
Myosin_head_motor_dom IPR001609 InterPro
Myosin_TH1 IPR010926 InterPro
P-loop_NTPase IPR027417 InterPro
Fungal_myosin-I_SH3 IPR035535 InterPro
SH3-like_dom_sf IPR036028 InterPro
MYSc_Myo1 IPR036072 InterPro
SH3_1 PF00018 Pfam
Myosin_head PF00063 Pfam
Myosin_TH1 PF06017 Pfam
S54570 S54570 PIR
SSF50044 SSF50044 SUPFAM
SSF52540 SSF52540 SUPFAM
MYSc_Myo1 cd01378 CDD
SH3_Myosin-I_fungi cd11858 CDD