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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q04439
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q04439 (Uniprot)
MYO5_YEAST
MYO5
Myosin-5
yeast
No
Protein Function
Uniprot:
One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and
promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.
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MoonDB Dissimilar Functions
Showing 1 to 3 of 3 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0043170
macromolecule metabolic process
992
GO:0097435
supramolecular fiber organization
1177
,
1242
4.36e-08
1.57e-47
GO:0097435
supramolecular fiber organization
1177
,
1242
GO:0006725
cellular aromatic compound metabolic process
933
4.17e-09
4.54e-39
GO:0097435
supramolecular fiber organization
1177
,
1242
GO:0044260
cellular macromolecule metabolic process
1311
6.22e-07
4.50e-41
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 20 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
933
GO:0010467
gene expression
933
GO:0006139
nucleobase-containing compound metabolic process
934
GO:0016310
phosphorylation
992
GO:0010467
gene expression
1017
GO:0034314
Arp2/3 complex-mediated actin nucleation
1019
GO:0034314
Arp2/3 complex-mediated actin nucleation
1055
GO:0007010
cytoskeleton organization
1177
GO:0007015
actin filament organization
1177
GO:0022607
cellular component assembly
1177
GO:0044087
regulation of cellular component biogenesis
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Cellular Components
Showing 1 to 10 of 15 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
884
GO:0043232
intracellular non-membrane-bounded organelle
933
GO:0005634
nucleus
948
GO:0043232
intracellular non-membrane-bounded organelle
954
GO:0043232
intracellular non-membrane-bounded organelle
992
GO:0005634
nucleus
1017
GO:0030479
actin cortical patch
1019
GO:0030479
actin cortical patch
1055
GO:0043232
intracellular non-membrane-bounded organelle
1069
GO:0043232
intracellular non-membrane-bounded organelle
1069
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 9 of 9 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006887
exocytosis
TAS
GO:0006897
endocytosis
IMP
GO:0006898
receptor-mediated endocytosis
IMP
GO:0006970
response to osmotic stress
TAS
GO:0007121
bipolar cellular bud site selection
TAS
GO:0009651
response to salt stress
IPI
GO:0031505
fungal-type cell wall organization
TAS
GO:0051666
actin cortical patch localization
IMP
GO:2000601
positive regulation of Arp2/3 complex-mediated actin nucleation
IMP
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0016459
myosin complex
IEA
GO:0030479
actin cortical patch
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 72 entries
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Interactor
Also a MoonDB EMF protein
2AAA_YEAST
No
2ABA_YEAST
No
ABP1_YEAST
No
ACAC_YEAST
No
ACBP_YEAST
No
AFT1_YEAST
No
AIM21_YEAST
No
APP1_YEAST
No
ARPC1_YEAST
No
ARPC4_YEAST
No
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Publications Associated
Showing 1 to 10 of 19 entries
Search:
PMID
Article Title
8614799
Role of type I myosins in receptor-mediated endocytosis in yeast.
8682864
Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.
9169872
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
9628892
The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization.
10648568
A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.
10648569
Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
10944111
An intact SH3 domain is required for myosin I-induced actin polymerization.
11901111
The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae.
12391157
Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
12725728
The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 21 entries
Search:
Domain Name
Domain ID
Source
Fungal_myosin-I_SH3
IPR035535
InterPro
Myosin_head
PF00063
Pfam
Myosin_head_motor_dom
IPR001609
InterPro
MYOSIN_MOTOR
PS51456
PROSITE
Myosin_TH1
IPR010926
InterPro
Myosin_TH1
PF06017
Pfam
MYOSINHEAVY
PR00193
PRINTS
MYSc
SM00242
SMART
MYSc_Myo1
IPR036072
InterPro
MYSc_Myo1
cd01378
CDD
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