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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P37370
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P37370 (Uniprot)
VRP1_YEAST
VRP1
Verprolin
yeast
No
Protein Function
Uniprot:
Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0097435
supramolecular fiber organization
1177
,
1242
GO:0006725
cellular aromatic compound metabolic process
962
4.17e-09
4.54e-39
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
962
GO:0006139
nucleobase-containing compound metabolic process
1177
GO:0007015
actin filament organization
1177
GO:0022607
cellular component assembly
1177
GO:0044087
regulation of cellular component biogenesis
1177
GO:0033043
regulation of organelle organization
1242
GO:0051666
actin cortical patch localization
1242
GO:0007015
actin filament organization
1242
GO:0034622
cellular macromolecular complex assembly
1242
GO:0006897
endocytosis
1242
GO:1903047
mitotic cell cycle process
1242
GO:0032505
reproduction of a single-celled organism
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
1177
GO:0005856
cytoskeleton
1177
GO:0005634
nucleus
1242
GO:0030479
actin cortical patch
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006897
endocytosis
IMP
GO:0007121
bipolar cellular bud site selection
IMP
GO:0032465
regulation of cytokinesis
IMP
GO:0051666
actin cortical patch localization
IMP
GO:2000601
positive regulation of Arp2/3 complex-mediated actin nucleation
IDA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000131
incipient cellular bud site
IDA
GO:0005935
cellular bud neck
IDA
GO:0030479
actin cortical patch
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
MYO3_YEAST
Yes:
P36006 (MoonDB)
CYK2_YEAST
Yes:
Q05080 (MoonDB)
RV167_YEAST
Yes:
P39743 (MoonDB)
MYO5_YEAST
Yes:
Q04439 (MoonDB)
BBC1_YEAST
Yes:
P47068 (MoonDB)
ACT_YEAST
Yes:
P60010 (MoonDB)
LAS17_YEAST
No
ASG1_YEAST
No
Publications Associated
PMID
Article Title
7968536
A proline-rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiae.
9169871
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
14562095
Global analysis of protein localization in budding yeast.
18407956
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19756047
Global analysis of the glycoproteome in Saccharomyces cerevisiae reveals new roles for protein glycosylation in eukaryotes.
19779198
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
WH2_dom
IPR003124
InterPro
WH2
PF02205
Pfam
WH2
PS51082
PROSITE
S51342
S51342
PIR
WH2
SM00246
SMART