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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P39743
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P39743 (Uniprot)
RV167_YEAST
RVS167
Reduced viability upon starvation protein 167
yeast
No
Protein Function
Uniprot:
Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0043170
macromolecule metabolic process
904
GO:0097435
supramolecular fiber organization
1242
4.36e-08
1.57e-47
GO:0009059
macromolecule biosynthetic process
1202
GO:0097435
supramolecular fiber organization
1242
2.11e-07
3.47e-31
GO:0097435
supramolecular fiber organization
1242
GO:0006725
cellular aromatic compound metabolic process
962
4.17e-09
4.54e-39
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
904
GO:0010467
gene expression
962
GO:0006139
nucleobase-containing compound metabolic process
1093
GO:0022607
cellular component assembly
1202
GO:0034645
cellular macromolecule biosynthetic process
1202
GO:0044271
cellular nitrogen compound biosynthetic process
1202
GO:0010467
gene expression
1202
GO:0090304
nucleic acid metabolic process
1242
GO:0051666
actin cortical patch localization
1242
GO:0007015
actin filament organization
1242
GO:0034622
cellular macromolecular complex assembly
1242
GO:0006897
endocytosis
1242
GO:1903047
mitotic cell cycle process
1242
GO:0032505
reproduction of a single-celled organism
1285
GO:0034645
cellular macromolecule biosynthetic process
1297
GO:0034622
cellular macromolecular complex assembly
1297
GO:0006897
endocytosis
1311
GO:0016070
RNA metabolic process
1311
GO:0010467
gene expression
1311
GO:0031326
regulation of cellular biosynthetic process
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
884
GO:0043232
intracellular non-membrane-bounded organelle
902
GO:0005634
nucleus
904
GO:0005634
nucleus
914
GO:0043232
intracellular non-membrane-bounded organelle
1071
GO:0043232
intracellular non-membrane-bounded organelle
1071
GO:0031981
nuclear lumen
1084
GO:0030427
site of polarized growth
1093
GO:0043232
intracellular non-membrane-bounded organelle
1140
GO:0005634
nucleus
1202
GO:0043232
intracellular non-membrane-bounded organelle
1202
GO:0005634
nucleus
1242
GO:0030479
actin cortical patch
1285
GO:0005634
nucleus
1297
GO:0030479
actin cortical patch
1297
GO:0012505
endomembrane system
1297
GO:0005634
nucleus
1311
GO:0005634
nucleus
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006897
endocytosis
IMP
GO:0016192
vesicle-mediated transport
IPI
GO:0051666
actin cortical patch localization
IMP
GO:0060988
lipid tube assembly
IDA
GO:0065009
regulation of molecular function
IEA
GO:0097320
plasma membrane tubulation
IMP
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005802
trans-Golgi network
IBA
GO:0030479
actin cortical patch
IDA
GO:0043332
mating projection tip
IDA
GO:1990528
Rvs161p-Rvs167p complex
IPI
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
MYO3_YEAST
Yes:
P36006 (MoonDB)
RL36B_YEAST
No
RV161_YEAST
No
2ABA_YEAST
No
ABP1_YEAST
No
ACF4_YEAST
No
ACT_YEAST
Yes:
P60010 (MoonDB)
AIM34_YEAST
No
AIM3_YEAST
No
APP1_YEAST
No
ATC8_YEAST
No
BSP1_YEAST
No
CAP_YEAST
No
CDC6_YEAST
No
COPG_YEAST
No
CTI6_YEAST
No
DSS1_YEAST
No
ECM30_YEAST
No
ENG2_YEAST
No
ERT1_YEAST
No
ESP1_YEAST
No
EXO70_YEAST
No
GFD2_YEAST
No
GTS1_YEAST
No
GYL1_YEAST
No
GYP5_YEAST
No
HUA1_YEAST
No
HUA2_YEAST
No
IMB3_YEAST
No
IOC3_YEAST
No
IVY1_YEAST
No
KA122_YEAST
No
LAS17_YEAST
No
LCP5_YEAST
No
MCM6_YEAST
No
MTC3_YEAST
No
MTH1_YEAST
No
MUS81_YEAST
No
MYO5_YEAST
Yes:
Q04439 (MoonDB)
NSR1_YEAST
No
PCL2_YEAST
No
PCL9_YEAST
No
PDR3_YEAST
No
PEF1_YEAST
No
PFKA1_YEAST
No
POM33_YEAST
No
PP2B1_YEAST
No
RL19A_YEAST
No
RRP3_YEAST
No
RRP7_YEAST
No
RT106_YEAST
No
SCD5_YEAST
No
SCM3_YEAST
No
SEC8_YEAST
No
SLA1_YEAST
Yes:
P32790 (MoonDB)
SLA2_YEAST
No
SLF1_YEAST
No
SLM2_YEAST
No
SLN1_YEAST
No
SNAPN_YEAST
No
SRP54_YEAST
No
STD1_YEAST
No
SYG2_YEAST
No
TBS1_YEAST
No
TDA7_YEAST
No
TFC6_YEAST
No
UBP7_YEAST
No
URA7_YEAST
No
VRP1_YEAST
Yes:
P37370 (MoonDB)
YBP2_YEAST
No
YD239_YEAST
No
YJ85_YEAST
No
YJT5_YEAST
No
YP091_YEAST
No
YSC84_YEAST
No
ZDS2_YEAST
Yes:
P54786 (MoonDB)
Publications Associated
PMID
Article Title
7719850
Defining protein interactions with yeast actin in vivo.
8336735
Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns.
9169867
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
9843683
Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton.
10388809
In vivo analysis of the domains of yeast Rvs167p suggests Rvs167p function is mediated through multiple protein interactions.
12857883
Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation.
12872131
A proteomics approach to understanding protein ubiquitination.
14562106
Global analysis of protein expression in yeast.
15561700
Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p.
15802519
Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.
18407956
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
22106047
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
22814378
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
SH3_domain
IPR001452
InterPro
BAR_dom
IPR004148
InterPro
AH/BAR_dom_sf
IPR027267
InterPro
SH3-like_dom_sf
IPR036028
InterPro
SH3_1
PF00018
Pfam
BAR
PF03114
Pfam
SH3DOMAIN
PR00452
PRINTS
SH3
PS50002
PROSITE
BAR
PS51021
PROSITE
S40887
S40887
PIR
SH3
SM00326
SMART
BAR
SM00721
SMART
SSF103657
SSF103657
SUPFAM
SSF50044
SSF50044
SUPFAM