Protein: P39743 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P39743 (Uniprot)	RV167_YEAST	RVS167	Reduced viability upon starvation protein 167	yeast	No

Protein Function

Uniprot: Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Could be implicated in cytoskeletal reorganization in response to environmental stresses and could act in the budding site selection mechanism.

MoonDB Dissimilar Functions

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1202	GO:0097435	supramolecular fiber organization	1242	2.11e-07	3.47e-31
GO:0043170	macromolecule metabolic process	904	GO:0097435	supramolecular fiber organization	1242	4.36e-08	1.57e-47
GO:0097435	supramolecular fiber organization	1242	GO:0006725	cellular aromatic compound metabolic process	962	4.17e-09	4.54e-39

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 19 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
904	GO:0010467	gene expression
962	GO:0006139	nucleobase-containing compound metabolic process
1093	GO:0022607	cellular component assembly
1202	GO:0034645	cellular macromolecule biosynthetic process
1202	GO:0044271	cellular nitrogen compound biosynthetic process
1202	GO:0010467	gene expression
1202	GO:0090304	nucleic acid metabolic process
1242	GO:0051666	actin cortical patch localization
1242	GO:0007015	actin filament organization
1242	GO:0034622	cellular macromolecular complex assembly

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
884	GO:0043232	intracellular non-membrane-bounded organelle
902	GO:0005634	nucleus
904	GO:0005634	nucleus
914	GO:0043232	intracellular non-membrane-bounded organelle
1071	GO:0043232	intracellular non-membrane-bounded organelle
1071	GO:0031981	nuclear lumen
1084	GO:0030427	site of polarized growth
1093	GO:0043232	intracellular non-membrane-bounded organelle
1140	GO:0005634	nucleus
1202	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006897	endocytosis	IMP
GO:0016192	vesicle-mediated transport	IPI
GO:0051666	actin cortical patch localization	IMP
GO:0060988	lipid tube assembly	IDA
GO:0065009	regulation of molecular function	IEA
GO:0097320	plasma membrane tubulation	IMP

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005802	trans-Golgi network	IBA
GO:0030479	actin cortical patch	IDA
GO:0043332	mating projection tip	IDA
GO:1990528	Rvs161p-Rvs167p complex	IPI

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 76 entries

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Interactor	Also a MoonDB EMF protein
2ABA_YEAST	No
ABP1_YEAST	No
ACF4_YEAST	No
ACT_YEAST	Yes: P60010 (MoonDB)
AIM34_YEAST	No
AIM3_YEAST	No
APP1_YEAST	No
ATC8_YEAST	No
BSP1_YEAST	No
CAP_YEAST	No

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Publications Associated

Showing 1 to 10 of 14 entries

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PMID	Article Title
7719850	Defining protein interactions with yeast actin in vivo.
8336735	Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns.
9169867	The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
9843683	Interaction of yeast Rvs167 and Pho85 cyclin-dependent kinase complexes may link the cell cycle to the actin cytoskeleton.
10388809	In vivo analysis of the domains of yeast Rvs167p suggests Rvs167p function is mediated through multiple protein interactions.
12857883	Regulation of the yeast amphiphysin homologue Rvs167p by phosphorylation.
12872131	A proteomics approach to understanding protein ubiquitination.
14562106	Global analysis of protein expression in yeast.
15561700	Characterizing the sphingolipid signaling pathway that remediates defects associated with loss of the yeast amphiphysin-like orthologs, Rvs161p and Rvs167p.
15802519	Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 14 entries

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Domain Name	Domain ID	Source
AH/BAR_dom_sf	IPR027267	InterPro
BAR	PF03114	Pfam
BAR	PS51021	PROSITE
BAR	SM00721	SMART
BAR_dom	IPR004148	InterPro
S40887	S40887	PIR
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3-like_dom_sf	IPR036028	InterPro
SH3_1	PF00018	Pfam

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