Protein: P54786 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P54786 (Uniprot)	ZDS2_YEAST	ZDS2	Protein ZDS2	yeast	No

Protein Function

Uniprot: Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling path more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0044260	cellular macromolecule metabolic process	1018	GO:0097435	supramolecular fiber organization	1177	6.22e-07	4.50e-41
GO:0097435	supramolecular fiber organization	1177	GO:0009059	macromolecule biosynthetic process	1202, 1322	2.11e-07	3.47e-31

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1018	GO:0016070	RNA metabolic process
1018	GO:0010468	regulation of gene expression
1093	GO:0022607	cellular component assembly
1177	GO:0007015	actin filament organization
1177	GO:0022607	cellular component assembly
1177	GO:0044087	regulation of cellular component biogenesis
1177	GO:0033043	regulation of organelle organization
1202	GO:0034645	cellular macromolecule biosynthetic process
1202	GO:0044271	cellular nitrogen compound biosynthetic process
1202	GO:0010467	gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
948	GO:0043232	intracellular non-membrane-bounded organelle
958	GO:0005935	cellular bud neck
1018	GO:0043232	intracellular non-membrane-bounded organelle
1018	GO:0005634	nucleus
1071	GO:0043232	intracellular non-membrane-bounded organelle
1071	GO:0031981	nuclear lumen
1084	GO:0030427	site of polarized growth
1093	GO:0043232	intracellular non-membrane-bounded organelle
1158	GO:0005634	nucleus
1177	GO:0005856	cytoskeleton

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000183	chromatin silencing at rDNA	IMP
GO:0001302	replicative cell aging	IMP
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP
GO:0030010	establishment of cell polarity	IGI
GO:0032880	regulation of protein localization	IGI
GO:0043086	negative regulation of catalytic activity	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IPI
GO:0005737	cytoplasm	IDA
GO:0005934	cellular bud tip	IDA
GO:0005935	cellular bud neck	IDA
GO:0030428	cell septum	IBA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
2ABA_YEAST	No
BEM3_YEAST	No
BNI1_YEAST	No
BOB1_YEAST	No
BOI2_YEAST	No
CDC11_YEAST	No
CLA4_YEAST	No
CSM1_YEAST	No
DSE1_YEAST	No
GIC1_YEAST	No

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Publications Associated

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PMID	Article Title
8816438	Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression.
9169872	The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
11489916	A protein interaction map for cell polarity development.
12704202	Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit.
14562106	Global analysis of protein expression in yeast.
16157662	Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant.
17287358	Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
17330950	Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
19779198	Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
S53963	S53963	PIR
ZDS1_C	IPR013941	InterPro
Zds_C	PF08632	Pfam
Zds_C	SM01327	SMART

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