Protein: P54786

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P54786 (Uniprot) ZDS2_YEAST ZDS2 Protein ZDS2 yeast No
Uniprot: Acts as a negative regulator of polarized growth via an alternative mechanism to ZDS1. In heat-stressed cells appears to play a role in localizing BCY1 to the cytoplasm. Seems to interact with, and down-regulate, CDC42. Also acts as a suppressor of PKC1. May act as an integration point for distinct signaling pathways helping to maintain a balance among these different pathways. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 1018 GO:0097435 supramolecular fiber organization 1177 6.22e-07 4.50e-41
GO:0097435 supramolecular fiber organization 1177 GO:0009059 macromolecule biosynthetic process 1202, 1322 2.11e-07 3.47e-31
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1018 GO:0016070 RNA metabolic process
1018 GO:0010468 regulation of gene expression
1093 GO:0022607 cellular component assembly
1177 GO:0007015 actin filament organization
1177 GO:0022607 cellular component assembly
1177 GO:0044087 regulation of cellular component biogenesis
1177 GO:0033043 regulation of organelle organization
1202 GO:0034645 cellular macromolecule biosynthetic process
1202 GO:0044271 cellular nitrogen compound biosynthetic process
1202 GO:0010467 gene expression
1202 GO:0090304 nucleic acid metabolic process
1322 GO:0034645 cellular macromolecule biosynthetic process
1322 GO:0044271 cellular nitrogen compound biosynthetic process
1322 GO:0051252 regulation of RNA metabolic process
1322 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
948 GO:0043232 intracellular non-membrane-bounded organelle
958 GO:0005935 cellular bud neck
1018 GO:0043232 intracellular non-membrane-bounded organelle
1018 GO:0005634 nucleus
1071 GO:0043232 intracellular non-membrane-bounded organelle
1071 GO:0031981 nuclear lumen
1084 GO:0030427 site of polarized growth
1093 GO:0043232 intracellular non-membrane-bounded organelle
1158 GO:0005634 nucleus
1177 GO:0005856 cytoskeleton
1177 GO:0005634 nucleus
1202 GO:0043232 intracellular non-membrane-bounded organelle
1202 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000183 chromatin silencing at rDNA IMP
GO:0001302 replicative cell aging IMP
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
GO:0030010 establishment of cell polarity IGI
GO:0032880 regulation of protein localization IGI
GO:0043086 negative regulation of catalytic activity IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IPI
GO:0005737 cytoplasm IDA
GO:0005934 cellular bud tip IDA
GO:0005935 cellular bud neck IDA
GO:0030428 cell septum IBA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005737 cytoplasm 5.14e-51 7.30e-86
PMID Article Title
8816438 Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression.
9169872 The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
11489916 A protein interaction map for cell polarity development.
12704202 Feedback inhibition on cell wall integrity signaling by Zds1 involves Gsk3 phosphorylation of a cAMP-dependent protein kinase regulatory subunit.
14562106 Global analysis of protein expression in yeast.
16157662 Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant.
17287358 Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
ZDS1_C IPR013941 InterPro
Zds_C PF08632 Pfam
S53963 S53963 PIR
Zds_C SM01327 SMART