Protein: P07359

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P07359 (Uniprot) GP1BA_HUMAN GP1BA Platelet glycoprotein Ib alpha chain human No
Uniprot: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 429 GO:0033036 macromolecule localization 517 4.56e-06 3.25e-28
Module ID (MoonGO) GO ID (BP) GO Name
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
306 GO:0070062 extracellular exosome
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000902 cell morphogenesis IEA
GO:0006469 negative regulation of protein kinase activity IBA
GO:0007155 cell adhesion IDA
GO:0007166 cell surface receptor signaling pathway TAS
GO:0007596 blood coagulation TAS
GO:0007597 blood coagulation, intrinsic pathway TAS
GO:0019221 cytokine-mediated signaling pathway IBA
GO:0030168 platelet activation TAS
GO:0030193 regulation of blood coagulation TAS
GO:0042730 fibrinolysis IDA
GO:0045652 regulation of megakaryocyte differentiation TAS
GO:0046426 negative regulation of JAK-STAT cascade IBA
GO:0070493 thrombin-activated receptor signaling pathway IEA
GO:0070527 platelet aggregation IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IBA
GO:0005886 plasma membrane TAS
GO:0005887 integral component of plasma membrane TAS
GO:0009986 cell surface IDA
GO:0016020 membrane IDA
GO:0031362 anchored component of external side of plasma membrane IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005737 cytoplasm GO:0005887 integral component of plasma membrane 4.51e-73 1.63e-08
PMID Article Title
1577776 Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications.
1586750 Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.
1730088 Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease.
2052556 Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.
2070794 Identification of the disulphide bonds in human platelet glycocalicin.
2845978 Structure of the human blood platelet membrane glycoprotein Ib alpha gene.
3303030 Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.
3497398 Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib.
7632942 The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.
7690774 Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.
7819107 Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome.
7873390 A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I).
8384898 Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor.
8486780 Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment.
9088113 StyI polymorphism at nucleotide 1610 in the human platelet glycoprotein Ib alpha gene.
9639514 Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein.
9651345 Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha.
10089893 Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families.
10391209 Characterization of single-nucleotide polymorphisms in coding regions of human genes.
11222377 Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome.
11858495 Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha.
12038791 A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha.
12087105 Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation.
12183630 Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
14521605 Identification of a novel point mutation in platelet glycoprotein Ibalpha, Gly to Ser at residue 233, in a Japanese family with platelet-type von Willebrand disease.
14711733 Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16263699 Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17008541 Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet.
18088087 Phosphoproteome of resting human platelets.
19828450 Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk.
OMIM ID Disease Name
153670 Bernard-Soulier syndrome A2, autosomal dominant
177820 Pseudo-von Willebrand disease
231200 Bernard-Soulier syndrome
258660 Non-arteritic anterior ischemic optic neuropathy
Domain Name Domain ID Source
NBHUIA A94174 PIR
I70082 I70082 PIR
LRRNT IPR000372 InterPro
Cys-rich_flank_reg_C IPR000483 InterPro
Leu-rich_rpt IPR001611 InterPro
Leu-rich_rpt_typical-subtyp IPR003591 InterPro
LRR_dom_sf IPR032675 InterPro
LRRNT PF01462 Pfam
LRR_8 PF13855 Pfam
LRR PS51450 PROSITE
LRRNT SM00013 SMART
LRRCT SM00082 SMART
LRR_TYP SM00369 SMART
SSF52058 SSF52058 SUPFAM