Protein: P00734 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P00734 (Uniprot)	THRB_HUMAN	F2	Prothrombin	human	Yes

Protein Function

Uniprot: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Dissimilar Functions Manual Curation

Function 1: Thrombin protease (cleaves fibrinogen to produce fibrin in the blood-clotting cascade).

Function 2: Ligand for cell surface receptor (ligand for G-protein coupled receptor PAR1 activation of this receptor causes platelets to stick together).

Publications (PMID): 1672265

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 15 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
22	GO:0019538	protein metabolic process
22	GO:0007165	signal transduction
199	GO:0006464	cellular protein modification process
199	GO:0060255	regulation of macromolecule metabolic process
199	GO:0007165	signal transduction
429	GO:0016070	RNA metabolic process
429	GO:0034645	cellular macromolecule biosynthetic process
429	GO:0044271	cellular nitrogen compound biosynthetic process
429	GO:0019538	protein metabolic process
429	GO:0010468	regulation of gene expression

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Cellular Components

Showing 1 to 10 of 11 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
22	GO:0005576	extracellular region
22	GO:0005886	plasma membrane
22	GO:0031982	vesicle
199	GO:0012505	endomembrane system
199	GO:0005576	extracellular region
199	GO:0070013	intracellular organelle lumen
235	GO:0012505	endomembrane system
235	GO:0016021	integral component of membrane
429	GO:0070013	intracellular organelle lumen
429	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 10 of 40 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001934	positive regulation of protein phosphorylation	IDA
GO:0006465	signal peptide processing	TAS
GO:0006508	proteolysis	TAS
GO:0006888	ER to Golgi vesicle-mediated transport	TAS
GO:0006953	acute-phase response	IEA
GO:0007166	cell surface receptor signaling pathway	IDA
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0007275	multicellular organism development	TAS
GO:0007596	blood coagulation	TAS
GO:0007597	blood coagulation, intrinsic pathway	TAS

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IDA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005796	Golgi lumen	TAS
GO:0005886	plasma membrane	TAS
GO:0009897	external side of plasma membrane	IDA
GO:0070062	extracellular exosome	IDA
GO:0072562	blood microparticle	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANT3_HUMAN	No
DDIT3_HUMAN	No
FA8_HUMAN	No
FIBA_HUMAN	No
GP1BA_HUMAN	Yes: P07359 (MoonDB)
HEP2_HUMAN	No
IPSP_HUMAN	No
OSTP_HUMAN	No
PAR1_HUMAN	No
TPA_HUMAN	No

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Publications Associated

Showing 1 to 10 of 47 entries

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PMID	Article Title
266717	Amino acid sequence of human prothrombin fragments 1 and 2.
873923	Primary structure of human prethrombin 2 and alpha-thrombin.
1349838	Detection of a single base substitution of the gene for prothrombin Tokushima. The application of PCR-SSCP for the genetic and molecular analysis of dysprothrombinemia.
1354985	Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity.
1421398	Prothrombin Himi: a compound heterozygote for two dysfunctional prothrombin molecules (Met-337-->Thr and Arg-388-->His).
2369893	Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibition.
2374926	The structure of a complex of recombinant hirudin and human alpha-thrombin.
2583108	The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.
2719946	Substitution of valine for glycine-558 in the congenital dysthrombin thrombin Quick II alters primary substrate specificity.
2825773	Nucleotide sequence of the gene for human prothrombin.

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OMIM Diseases Associated

Showing 1 to 4 of 4 entries

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OMIM ID	Disease Name
188050	Thrombophilia due to thrombin defect
601367	Ischemic stroke
613679	Factor II deficiency
614390	Pregnancy loss, recurrent, 2

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Protein Domains Associated

Showing 1 to 10 of 38 entries

Search:

Domain Name	Domain ID	Source
CHYMOTRYPSIN	PR00722	PRINTS
Gla	PF00594	Pfam
GLA	SM00069	SMART
GLA-like_dom_SF	IPR035972	InterPro
GLA_1	PS00011	PROSITE
GLA_2	PS50998	PROSITE
GLA_domain	IPR000294	InterPro
GLABLOOD	PR00001	PRINTS
KR	SM00130	SMART
Kringle	IPR000001	InterPro

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