Protein: Q96Q45 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q96Q45 (Uniprot)	TM237_HUMAN	TMEM237	Transmembrane protein 237	human	No

Protein Function

Uniprot: Component of the transition zone in primary cilia. Required for ciliogenesis.

Showing 1 to 3 of 3 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0034641	cellular nitrogen compound metabolic process	789	GO:0007165	signal transduction	803	4.22e-144	6.90e-18
GO:0034641	cellular nitrogen compound metabolic process	789	GO:0022610	biological adhesion	869	6.87e-63	4.34e-65
GO:0043170	macromolecule metabolic process	22	GO:0022610	biological adhesion	869	2.68e-16	4.92e-03

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
22	GO:0019538	protein metabolic process
22	GO:0007165	signal transduction
128	GO:0007165	signal transduction
358	GO:0006464	cellular protein modification process
358	GO:0060255	regulation of macromolecule metabolic process
358	GO:0007165	signal transduction
716	GO:0010646	regulation of cell communication
716	GO:0023051	regulation of signaling
716	GO:0007165	signal transduction
789	GO:0044271	cellular nitrogen compound biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
14	GO:0031410	cytoplasmic vesicle
14	GO:0005829	cytosol
14	GO:0005783	endoplasmic reticulum
22	GO:0005576	extracellular region
22	GO:0005886	plasma membrane
22	GO:0031982	vesicle
65	GO:0012505	endomembrane system
65	GO:0016021	integral component of membrane
85	GO:0016021	integral component of membrane
128	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0030111	regulation of Wnt signaling pathway	IMP
GO:0060271	cilium assembly	IMP

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0016020	membrane	IDA
GO:0016021	integral component of membrane	IEA
GO:0035869	ciliary transition zone	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 130 entries

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Interactor	Also a MoonDB EMF protein
A0A1B0GTW0_HUMAN	No
A5D903_HUMAN	No
A5PKU2_HUMAN	No
ABHGA_HUMAN	No
ADIPO_HUMAN	No
AL3A2_HUMAN	No
APOD_HUMAN	No
APOL3_HUMAN	No
AT131_HUMAN	No
BAP31_HUMAN	No

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Publications Associated

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PMID	Article Title
11586298	A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
17974005	The full-ORF clone resource of the German cDNA consortium.
22152675	TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.
26595381	TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614424	Joubert syndrome 14

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Protein Domains Associated

Showing 1 to 3 of 3 entries

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Domain Name	Domain ID	Source
PTHR28388	PTHR28388	PANTHER
TMEM237	IPR029409	InterPro
TMEM237	PF15383	Pfam

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