Protein: P15692

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P15692 (Uniprot) VEGFA_HUMAN VEGFA Vascular endothelial growth factor A human No
Uniprot: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 266 GO:0022610 biological adhesion 869 2.22e-23 6.08e-57
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
266 GO:0034645 cellular macromolecule biosynthetic process
266 GO:0044271 cellular nitrogen compound biosynthetic process
266 GO:0006464 cellular protein modification process
266 GO:0070887 cellular response to chemical stimulus
266 GO:0032270 positive regulation of cellular protein metabolic process
266 GO:0048584 positive regulation of response to stimulus
266 GO:0006508 proteolysis
266 GO:0050790 regulation of catalytic activity
266 GO:0031326 regulation of cellular biosynthetic process
266 GO:0010468 regulation of gene expression
266 GO:2000026 regulation of multicellular organismal development
266 GO:0019219 regulation of nucleobase-containing compound metabolic process
266 GO:0009966 regulation of signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
358 GO:0006464 cellular protein modification process
358 GO:0060255 regulation of macromolecule metabolic process
358 GO:0007165 signal transduction
869 GO:0007155 cell adhesion
869 GO:0048468 cell development
869 GO:0016477 cell migration
869 GO:0000902 cell morphogenesis
869 GO:0044255 cellular lipid metabolic process
869 GO:0071363 cellular response to growth factor stimulus
869 GO:0072359 circulatory system development
869 GO:0009059 macromolecule biosynthetic process
869 GO:0022008 neurogenesis
869 GO:0019637 organophosphate metabolic process
869 GO:0018108 peptidyl-tyrosine phosphorylation
869 GO:0120036 plasma membrane bounded cell projection organization
869 GO:1902533 positive regulation of intracellular signal transduction
869 GO:0045860 positive regulation of protein kinase activity
869 GO:0043408 regulation of MAPK cascade
869 GO:2000145 regulation of cell motility
869 GO:0042127 regulation of cell proliferation
869 GO:0010468 regulation of gene expression
869 GO:2000026 regulation of multicellular organismal development
869 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
266 GO:0031410 cytoplasmic vesicle
266 GO:0012505 endomembrane system
266 GO:0005576 extracellular region
266 GO:0070013 intracellular organelle lumen
266 GO:0005634 nucleus
266 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
358 GO:0012505 endomembrane system
358 GO:0005615 extracellular space
358 GO:0005886 plasma membrane
358 GO:0031982 vesicle
396 GO:0012505 endomembrane system
799 GO:0012505 endomembrane system
799 GO:0016021 integral component of membrane
869 GO:0012505 endomembrane system
869 GO:0005615 extracellular space
869 GO:0044459 plasma membrane part
869 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0001525 angiogenesis IDA
GO:0001541 ovarian follicle development ISS
GO:0001569 branching involved in blood vessel morphogenesis ISS
GO:0001570 vasculogenesis TAS
GO:0001666 response to hypoxia IDA
GO:0001701 in utero embryonic development ISS
GO:0001822 kidney development ISS
GO:0001934 positive regulation of protein phosphorylation IDA
GO:0001938 positive regulation of endothelial cell proliferation IDA
GO:0002042 cell migration involved in sprouting angiogenesis IDA
GO:0002052 positive regulation of neuroblast proliferation ISS
GO:0002053 positive regulation of mesenchymal cell proliferation ISS
GO:0002092 positive regulation of receptor internalization IDA
GO:0002576 platelet degranulation TAS
GO:0002687 positive regulation of leukocyte migration TAS
GO:0003007 heart morphogenesis ISS
GO:0003151 outflow tract morphogenesis ISS
GO:0003169 coronary vein morphogenesis ISS
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS
GO:0007399 nervous system development TAS
GO:0007498 mesoderm development ISS
GO:0007595 lactation ISS
GO:0008284 positive regulation of cell proliferation IDA
GO:0008360 regulation of cell shape IDA
GO:0010469 regulation of receptor activity IEA
GO:0010595 positive regulation of endothelial cell migration IDA
GO:0010628 positive regulation of gene expression IDA
GO:0030224 monocyte differentiation IDA
GO:0030225 macrophage differentiation IDA
GO:0030324 lung development ISS
GO:0030335 positive regulation of cell migration IDA
GO:0030823 regulation of cGMP metabolic process IDA
GO:0030855 epithelial cell differentiation ISS
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IDA
GO:0031077 post-embryonic camera-type eye development ISS
GO:0031334 positive regulation of protein complex assembly IDA
GO:0031954 positive regulation of protein autophosphorylation IDA
GO:0032147 activation of protein kinase activity IDA
GO:0032793 positive regulation of CREB transcription factor activity IDA
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
GO:0035148 tube formation IDA
GO:0035767 endothelial cell chemotaxis IDA
GO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
GO:0036303 lymph vessel morphogenesis ISS
GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway IDA
GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway IDA
GO:0038190 VEGF-activated neuropilin signaling pathway ISS
GO:0040007 growth ISS
GO:0042462 eye photoreceptor cell development ISS
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
GO:0043066 negative regulation of apoptotic process IMP
GO:0043129 surfactant homeostasis ISS
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
GO:0043406 positive regulation of MAP kinase activity IDA
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA
GO:0045766 positive regulation of angiogenesis IDA
GO:0045785 positive regulation of cell adhesion IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048469 cell maturation ISS
GO:0048593 camera-type eye morphogenesis ISS
GO:0048739 cardiac muscle fiber development ISS
GO:0048754 branching morphogenesis of an epithelial tube ISS
GO:0048842 positive regulation of axon extension involved in axon guidance ISS
GO:0048844 artery morphogenesis ISS
GO:0050679 positive regulation of epithelial cell proliferation ISS
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
GO:0050918 positive chemotaxis IDA
GO:0050927 positive regulation of positive chemotaxis IDA
GO:0050930 induction of positive chemotaxis NAS
GO:0051272 positive regulation of cellular component movement IDA
GO:0051781 positive regulation of cell division IEA
GO:0051894 positive regulation of focal adhesion assembly IDA
GO:0060319 primitive erythrocyte differentiation ISS
GO:0060749 mammary gland alveolus development ISS
GO:0060754 positive regulation of mast cell chemotaxis IBA
GO:0060948 cardiac vascular smooth muscle cell development ISS
GO:0060982 coronary artery morphogenesis ISS
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IMP
GO:0071456 cellular response to hypoxia IDA
GO:0071542 dopaminergic neuron differentiation ISS
GO:0071679 commissural neuron axon guidance ISS
GO:0090037 positive regulation of protein kinase C signaling IDA
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis ISS
GO:0090259 regulation of retinal ganglion cell axon guidance ISS
GO:0097475 motor neuron migration ISS
GO:1900086 positive regulation of peptidyl-tyrosine autophosphorylation IDA
GO:1900745 positive regulation of p38MAPK cascade IDA
GO:1901727 positive regulation of histone deacetylase activity IDA
GO:1902336 positive regulation of retinal ganglion cell axon guidance ISS
GO:1903572 positive regulation of protein kinase D signaling IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005578 proteinaceous extracellular matrix NAS
GO:0005615 extracellular space IDA
GO:0005737 cytoplasm IDA
GO:0009986 cell surface IDA
GO:0016020 membrane IEA
GO:0030141 secretory granule IDA
GO:0031093 platelet alpha granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005578 proteinaceous extracellular matrix GO:0005737 cytoplasm 3.97e-02 1.23e-03
PMID Article Title
1567395 AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor.
1711045 The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
1791831 The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.
2479986 Vascular endothelial growth factor is a secreted angiogenic mitogen.
2479987 Vascular permeability factor, an endothelial cell mitogen related to PDGF.
2584205 Human vascular permeability factor. Isolation from U937 cells.
7678805 Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.
9054410 VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix.
9207067 Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
9336848 1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.
9351807 The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93-A resolution: multiple copy flexibility and receptor binding.
9450968 Identification of a human VPF/VEGF 3' untranslated region mediating hypoxia-induced mRNA stability.
9634701 Solution structure of the heparin-binding domain of vascular endothelial growth factor.
9878851 Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183.
9922142 Crystal structure of the complex between VEGF and a receptor-blocking peptide.
10067980 Human Muller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor.
10464055 Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant.
11427521 Vascular endothelial growth factor induces cyclooxygenase-dependent proliferation of endothelial cells via the VEGF-2 receptor.
11563986 A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon.
11731620 New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation.
11978667 A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes.
12124351 VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma.
14574404 The DNA sequence and analysis of human chromosome 6.
14764596 Control of the vascular endothelial growth factor internal ribosome entry site (IRES) activity and translation initiation by alternatively spliced coding sequences.
15340161 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15520188 VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression.
15896327 Nuclear localization of long-VEGF is associated with hypoxia and tumor angiogenesis.
16489009 Minimal active domain and mechanism of action of the angiogenesis inhibitor histidine-rich glycoprotein.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
22009797 RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.
26503042 CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
26789244 Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.
OMIM ID Disease Name
603933 Microvascular complications of diabetes 1
Domain Name Domain ID Source
A41551 A41551 PIR
PDGF/VEGF_dom IPR000072 InterPro
PD_growth_factor_CS IPR023581 InterPro
VEGF_C IPR027928 InterPro
Cystine-knot_cytokine IPR029034 InterPro
VEGF_C_sf IPR036841 InterPro
PDGF PF00341 Pfam
VEGF_C PF14554 Pfam
PDGF_1 PS00249 PROSITE
PDGF_2 PS50278 PROSITE
PDGF SM00141 SMART
SSF57501 SSF57501 SUPFAM
SSF57593 SSF57593 SUPFAM
PDGF cd00135 CDD