Protein: P15692 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P15692 (Uniprot)	VEGFA_HUMAN	VEGFA	Vascular endothelial growth factor A	human	No

Protein Function

Uniprot: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 bin more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	266	GO:0022610	biological adhesion	869	2.22e-23	6.08e-57

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
187	GO:0007166	cell surface receptor signaling pathway
187	GO:0006464	cellular protein modification process
187	GO:0070887	cellular response to chemical stimulus
187	GO:0035556	intracellular signal transduction
187	GO:0006928	movement of cell or subcellular component
187	GO:0006796	phosphate-containing compound metabolic process
187	GO:0010647	positive regulation of cell communication
187	GO:0048584	positive regulation of response to stimulus
187	GO:0023056	positive regulation of signaling
187	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
187	GO:0005829	cytosol
187	GO:0005886	plasma membrane
266	GO:0031410	cytoplasmic vesicle
266	GO:0012505	endomembrane system
266	GO:0005576	extracellular region
266	GO:0070013	intracellular organelle lumen
266	GO:0005634	nucleus
266	GO:0005886	plasma membrane
355	GO:0044459	plasma membrane part
358	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001525	angiogenesis	IDA
GO:0001541	ovarian follicle development	ISS
GO:0001569	branching involved in blood vessel morphogenesis	ISS
GO:0001570	vasculogenesis	TAS
GO:0001666	response to hypoxia	IDA
GO:0001701	in utero embryonic development	ISS
GO:0001822	kidney development	ISS
GO:0001934	positive regulation of protein phosphorylation	IDA
GO:0001938	positive regulation of endothelial cell proliferation	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005578	proteinaceous extracellular matrix	NAS
GO:0005615	extracellular space	IDA
GO:0005737	cytoplasm	IDA
GO:0009986	cell surface	IDA
GO:0016020	membrane	IEA
GO:0030141	secretory granule	IDA
GO:0031093	platelet alpha granule lumen	TAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005578	proteinaceous extracellular matrix	GO:0005737	cytoplasm	3.97e-02	1.23e-03

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANGP2_HUMAN	No
NRP1_HUMAN	No
PGBM_HUMAN	No
PLGF_HUMAN	No
SPRC_HUMAN	No
TM237_HUMAN	Yes: Q96Q45 (MoonDB)
TMG4_HUMAN	No
U2AF1_HUMAN	No
UBIA1_HUMAN	No
VEGFB_HUMAN	No

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Publications Associated

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PMID	Article Title
1567395	AIDS-associated Kaposi's sarcoma cells in culture express vascular endothelial growth factor.
1711045	The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
1791831	The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA.
2479986	Vascular endothelial growth factor is a secreted angiogenic mitogen.
2479987	Vascular permeability factor, an endothelial cell mitogen related to PDGF.
2584205	Human vascular permeability factor. Isolation from U937 cells.
7678805	Synthesis and assembly of functionally active human vascular endothelial growth factor homodimers in insect cells.
9054410	VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix.
9207067	Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.
9336848	1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor.

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OMIM Diseases Associated

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OMIM ID	Disease Name
603933	Microvascular complications of diabetes 1

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Protein Domains Associated

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Domain Name	Domain ID	Source
A41551	A41551	PIR
Cystine-knot_cytokine	IPR029034	InterPro
PD_growth_factor_CS	IPR023581	InterPro
PDGF	PF00341	Pfam
PDGF	SM00141	SMART
PDGF	cd00135	CDD
PDGF/VEGF_dom	IPR000072	InterPro
PDGF_1	PS00249	PROSITE
PDGF_2	PS50278	PROSITE
SSF57501	SSF57501	SUPFAM

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