Protein: P63208

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P63208 (Uniprot) SKP1_HUMAN SKP1 S-phase kinase-associated protein 1 human No
Uniprot: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006793 phosphorus metabolic process 491 GO:0009059 macromolecule biosynthetic process 87 1.25e-35 4.53e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
24 GO:0016070 RNA metabolic process
24 GO:0006464 cellular protein modification process
24 GO:0034654 nucleobase-containing compound biosynthetic process
24 GO:0006796 phosphate-containing compound metabolic process
24 GO:0031325 positive regulation of cellular metabolic process
24 GO:0010604 positive regulation of macromolecule metabolic process
24 GO:0051173 positive regulation of nitrogen compound metabolic process
24 GO:2000112 regulation of cellular macromolecule biosynthetic process
24 GO:0010468 regulation of gene expression
24 GO:0019219 regulation of nucleobase-containing compound metabolic process
24 GO:0051246 regulation of protein metabolic process
24 GO:0007165 signal transduction
87 GO:0034645 cellular macromolecule biosynthetic process
87 GO:0060255 regulation of macromolecule metabolic process
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
218 GO:0060255 regulation of macromolecule metabolic process
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
330 GO:0006464 cellular protein modification process
330 GO:0006796 phosphate-containing compound metabolic process
330 GO:0031325 positive regulation of cellular metabolic process
330 GO:0010604 positive regulation of macromolecule metabolic process
330 GO:0051173 positive regulation of nitrogen compound metabolic process
330 GO:2000112 regulation of cellular macromolecule biosynthetic process
330 GO:0010468 regulation of gene expression
330 GO:0019219 regulation of nucleobase-containing compound metabolic process
330 GO:0051246 regulation of protein metabolic process
330 GO:0007165 signal transduction
330 GO:0006351 transcription, DNA-templated
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
490 GO:0031325 positive regulation of cellular metabolic process
490 GO:0010604 positive regulation of macromolecule metabolic process
490 GO:0051173 positive regulation of nitrogen compound metabolic process
490 GO:0009966 regulation of signal transduction
490 GO:0006357 regulation of transcription from RNA polymerase II promoter
491 GO:0006796 phosphate-containing compound metabolic process
547 GO:0060255 regulation of macromolecule metabolic process
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
554 GO:0016070 RNA metabolic process
554 GO:0010468 regulation of gene expression
610 GO:0008219 cell death
610 GO:0007166 cell surface receptor signaling pathway
610 GO:0006464 cellular protein modification process
610 GO:0031324 negative regulation of cellular metabolic process
610 GO:0051172 negative regulation of nitrogen compound metabolic process
610 GO:0016310 phosphorylation
610 GO:0010604 positive regulation of macromolecule metabolic process
610 GO:0051173 positive regulation of nitrogen compound metabolic process
610 GO:0008104 protein localization
610 GO:0051128 regulation of cellular component organization
610 GO:0032268 regulation of cellular protein metabolic process
610 GO:0009966 regulation of signal transduction
610 GO:0006355 regulation of transcription, DNA-templated
629 GO:0007165 signal transduction
668 GO:0006464 cellular protein modification process
668 GO:0006796 phosphate-containing compound metabolic process
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
683 GO:0006139 nucleobase-containing compound metabolic process
683 GO:0060255 regulation of macromolecule metabolic process
705 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
24 GO:0005829 cytosol
24 GO:0005654 nucleoplasm
87 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
162 GO:0005634 nucleus
216 GO:0005829 cytosol
218 GO:0005634 nucleus
247 GO:0005634 nucleus
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
317 GO:0005829 cytosol
330 GO:0005829 cytosol
330 GO:0005654 nucleoplasm
376 GO:0005829 cytosol
376 GO:0005634 nucleus
413 GO:0005654 nucleoplasm
490 GO:0005654 nucleoplasm
491 GO:0005829 cytosol
491 GO:0043232 intracellular non-membrane-bounded organelle
491 GO:0005634 nucleus
547 GO:0005654 nucleoplasm
549 GO:0005829 cytosol
549 GO:0005634 nucleus
554 GO:0005634 nucleus
610 GO:0031981 nuclear lumen
629 GO:0005829 cytosol
629 GO:0031982 vesicle
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
683 GO:0005829 cytosol
683 GO:0070013 intracellular organelle lumen
683 GO:0005634 nucleus
705 GO:0070013 intracellular organelle lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000086 G2/M transition of mitotic cell cycle TAS
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0006879 cellular iron ion homeostasis TAS
GO:0010265 SCF complex assembly TAS
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
GO:0016055 Wnt signaling pathway TAS
GO:0016567 protein ubiquitination IDA
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
GO:0035518 histone H2A monoubiquitination IDA
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043687 post-translational protein modification TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051403 stress-activated MAPK cascade TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0051457 maintenance of protein location in nucleus IPI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0019005 SCF ubiquitin ligase complex IDA
GO:0031467 Cul7-RING ubiquitin ligase complex IDA
GO:0031519 PcG protein complex IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
PMID Article Title
7553852 p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
8530064 A novel cDNA with homology to an RNA polymerase II elongation factors maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l).
9031623 Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter.
11099048 Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
11389839 Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.
11961546 Structure of the Cul1-Rbx1-Skp1-F box Skp2 SCF ubiquitin ligase complex.
12481031 CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.
12820959 Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16209941 Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
16880511 Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
17389369 Structural basis for the selection of glycosylated substrates by SCF(Fbs1) ubiquitin ligase.
17434132 Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases.
18203720 Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20181953 Structural basis of dimerization-dependent ubiquitination by the SCF(Fbx4) ubiquitin ligase.
20596027 SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22113614 FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas.
23431138 Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25503564 Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
25704143 Cep68 can be regulated by Nek2 and SCF complex.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
I39170 I39170 PIR
SKP1-like IPR001232 InterPro
SKP1/BTB/POZ_sf IPR011333 InterPro
Skp1_comp_dimer IPR016072 InterPro
Skp1_comp_POZ IPR016073 InterPro
SKP1 IPR016897 InterPro
SKP1-like_dim_sf IPR036296 InterPro
Skp1 PF01466 Pfam
Skp1_POZ PF03931 Pfam
E3_ubiquit_lig_SCF_Skp PIRSF028729 PIRSF
Skp1 SM00512 SMART
SSF54695 SSF54695 SUPFAM
SSF81382 SSF81382 SUPFAM