Protein: Q94420

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q94420 (Uniprot) MEL26_CAEEL mel-26 Protein maternal effect lethal 26 worm No
Uniprot: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922). Controls degradation of microtubule severing protein mei-1 (PubMed:14528312). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89 (PubMed:22621901). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 2261 GO:0006139 nucleobase-containing compound metabolic process 2664 1.61e-11 3.68e-10
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2261 GO:0044267 cellular protein metabolic process
2446 GO:0060255 regulation of macromolecule metabolic process
2557 GO:0016070 RNA metabolic process
2557 GO:0010467 gene expression
2557 GO:0060255 regulation of macromolecule metabolic process
2664 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2261 GO:0043232 intracellular non-membrane-bounded organelle
2261 GO:0005634 nucleus
2557 GO:0005634 nucleus
2664 GO:0005694 chromosome
2664 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0030162 regulation of proteolysis IBA
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA
GO:0044257 cellular protein catabolic process IMP
GO:0071688 striated muscle myosin thick filament assembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000793 condensed chromosome IDA
GO:0005737 cytoplasm IDA
GO:0005938 cell cortex IDA
GO:0016020 membrane IDA
GO:0019005 SCF ubiquitin ligase complex IBA
GO:0031430 M band IDA
GO:0031674 I band IDA
GO:0032154 cleavage furrow IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9725834 Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component.
9851916 Genome sequence of the nematode C. elegans: a platform for investigating biology.
13679922 BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
14528312 Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
22621901 UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
No results found.
Domain Name Domain ID Source
BTB/POZ_dom IPR000210 InterPro
MATH/TRAF_dom IPR002083 InterPro
TRAF-like IPR008974 InterPro
SKP1/BTB/POZ_sf IPR011333 InterPro
SPOP_C IPR034089 InterPro
BTB PF00651 Pfam
BTB PS50097 PROSITE
MATH PS50144 PROSITE
MATH SM00061 SMART
BTB SM00225 SMART
SSF49599 SSF49599 SUPFAM
SSF54695 SSF54695 SUPFAM
T28056 T28056 PIR
SPOP_C cd14734 CDD