Protein: P55853

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P55853 (Uniprot) SUMO_CAEEL smo-1 Small ubiquitin-related modifier worm No
Uniprot: Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process (PubMed:11806825). Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction (PubMed:11806825, PubMed:25475837). Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17 (PubMed:15107848, PubMed:16701625). Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates (PubMed:15466489, PubMed:15689373, PubMed:15990876, PubMed:24349540). Probably by sumoylating bet-1, prevents muscle myosin depletion in aging adults probably by preventing myoblast growth factor receptor egl-15 overexpression (PubMed:24285704). Plays a role in the attenuation of the let-60/ras pathway (PubMed:24349540, PubMed:24285704). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 2261 GO:0006139 nucleobase-containing compound metabolic process 2664 1.61e-11 3.68e-10
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2261 GO:0044267 cellular protein metabolic process
2664 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2261 GO:0043232 intracellular non-membrane-bounded organelle
2261 GO:0005634 nucleus
2664 GO:0005694 chromosome
2664 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0002119 nematode larval development IMP
GO:0007080 mitotic metaphase plate congression IMP
GO:0009792 embryo development ending in birth or egg hatching IMP
GO:0016925 protein sumoylation IMP
GO:0034502 protein localization to chromosome IMP
GO:0051306 mitotic sister chromatid separation IMP
GO:0070194 synaptonemal complex disassembly IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IBA
GO:0005694 chromosome IEA
GO:0005737 cytoplasm IEA
GO:0005815 microtubule organizing center IEA
GO:0005819 spindle IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9119407 SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
9175795 Identification and characterization of the SMT3 cDNA and gene from nematode Caenorhabditis elegans.
9851916 Genome sequence of the nematode C. elegans: a platform for investigating biology.
11806825 Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
15107848 SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
15466489 The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
15689373 Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
15990876 Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
16701625 The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
24285704 Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.
24349540 An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.
25475837 Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.
No results found.
Domain Name Domain ID Source
Ubiquitin_dom IPR000626 InterPro
Rad60/SUMO-like_dom IPR022617 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
Sumo IPR033950 InterPro
JC5582 JC5582 PIR
Rad60-SLD PF11976 Pfam
UBIQUITIN_2 PS50053 PROSITE
UBQ SM00213 SMART
SSF54236 SSF54236 SUPFAM
Sumo cd01763 CDD