Protein: Q92890

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q92890 (Uniprot) UFD1_HUMAN UFD1 Ubiquitin recognition factor in ER-associated degradation protein 1 human No
Uniprot: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 27 GO:0033036 macromolecule localization 517 4.58e-19 9.70e-72
GO:0006725 cellular aromatic compound metabolic process 484 GO:0033036 macromolecule localization 517 1.29e-20 6.46e-74
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
27 GO:0090304 nucleic acid metabolic process
27 GO:0060255 regulation of macromolecule metabolic process
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
420 GO:0006464 cellular protein modification process
484 GO:0006139 nucleobase-containing compound metabolic process
484 GO:1901362 organic cyclic compound biosynthetic process
484 GO:0019538 protein metabolic process
484 GO:0060255 regulation of macromolecule metabolic process
484 GO:0007165 signal transduction
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
756 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
27 GO:0031981 nuclear lumen
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
420 GO:0005829 cytosol
420 GO:0005634 nucleus
484 GO:0070013 intracellular organelle lumen
484 GO:0005634 nucleus
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
756 GO:0005576 extracellular region
756 GO:0005886 plasma membrane
756 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001501 skeletal system development TAS
GO:0006511 ubiquitin-dependent protein catabolic process IMP
GO:0016579 protein deubiquitination TAS
GO:0030970 retrograde protein transport, ER to cytosol IMP
GO:0032480 negative regulation of type I interferon production IMP
GO:0039536 negative regulation of RIG-I signaling pathway IMP
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA
GO:0070987 error-free translesion synthesis TAS
GO:0071712 ER-associated misfolded protein catabolic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005783 endoplasmic reticulum IDA
GO:0005829 cytosol IEA
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex IDA
GO:0036501 UFD1-NPL4 complex IPI
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005654 nucleoplasm GO:0005783 endoplasmic reticulum 1.84e-53 1.21e-118
PMID Article Title
9063746 UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.
10591208 The DNA sequence of human chromosome 22.
11574150 Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).
15461802 A genome annotation-driven approach to cloning the human ORFeome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21571647 Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
26471729 A non-canonical role of the p97 complex in RIG-I antiviral signaling.
No results found.
Domain Name Domain ID Source
Ufd1-like IPR004854 InterPro
UFD1 PF03152 Pfam
PTHR12555 PTHR12555 PANTHER