Protein: Q92890 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q92890 (Uniprot)	UFD1_HUMAN	UFD1	Ubiquitin recognition factor in ER-associated degradation protein 1	human	No

Protein Function

Uniprot: Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasom more..

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	27	GO:0033036	macromolecule localization	517	4.58e-19	9.70e-72
GO:0006725	cellular aromatic compound metabolic process	484	GO:0033036	macromolecule localization	517	1.29e-20	6.46e-74

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
27	GO:0090304	nucleic acid metabolic process
27	GO:0060255	regulation of macromolecule metabolic process
159	GO:0006464	cellular protein modification process
159	GO:0006355	regulation of transcription, DNA-templated
159	GO:0007165	signal transduction
420	GO:0006464	cellular protein modification process
484	GO:0006139	nucleobase-containing compound metabolic process
484	GO:1901362	organic cyclic compound biosynthetic process
484	GO:0019538	protein metabolic process
484	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
27	GO:0031981	nuclear lumen
159	GO:0005829	cytosol
159	GO:0005654	nucleoplasm
420	GO:0005829	cytosol
420	GO:0005634	nucleus
484	GO:0070013	intracellular organelle lumen
484	GO:0005634	nucleus
517	GO:0005829	cytosol
517	GO:0012505	endomembrane system
517	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

Showing 1 to 9 of 9 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001501	skeletal system development	TAS
GO:0006511	ubiquitin-dependent protein catabolic process	IMP
GO:0016579	protein deubiquitination	TAS
GO:0030970	retrograde protein transport, ER to cytosol	IMP
GO:0032480	negative regulation of type I interferon production	IMP
GO:0039536	negative regulation of RIG-I signaling pathway	IMP
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0070987	error-free translesion synthesis	TAS
GO:0071712	ER-associated misfolded protein catabolic process	IMP

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005783	endoplasmic reticulum	IDA
GO:0005829	cytosol	IEA
GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex	IDA
GO:0036501	UFD1-NPL4 complex	IPI

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 2 of 2 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005654	nucleoplasm	GO:0005783	endoplasmic reticulum	1.84e-53	1.21e-118

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A2MG_HUMAN	Yes: P01023 (MoonDB)
ANC2_HUMAN	No
CHM2A_HUMAN	No
F13A_HUMAN	No
HSPB1_HUMAN	Yes: P04792 (MoonDB)
IGHM_HUMAN	No
LRRK2_HUMAN	No
MASP1_HUMAN	No
NPL4_HUMAN	No
P53_HUMAN	Yes: P04637 (MoonDB)

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Publications Associated

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PMID	Article Title
9063746	UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.
10591208	The DNA sequence of human chromosome 22.
11574150	Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).
15461802	A genome annotation-driven approach to cloning the human ORFeome.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460	Initial characterization of the human central proteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 3 of 3 entries

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Domain Name	Domain ID	Source
PTHR12555	PTHR12555	PANTHER
UFD1	PF03152	Pfam
Ufd1-like	IPR004854	InterPro

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