Protein: P49710 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P49710 (Uniprot)	HCLS1_MOUSE	Hcls1	Hematopoietic lineage cell-specific protein	mouse	No

Protein Function

Uniprot: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1795	GO:0007165	signal transduction	1492	2.28e-48	1.95e-17

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1492	GO:0035556	intracellular signal transduction
1492	GO:0010646	regulation of cell communication
1492	GO:0060255	regulation of macromolecule metabolic process
1492	GO:0023051	regulation of signaling
1795	GO:0034645	cellular macromolecule biosynthetic process
1795	GO:0018193	peptidyl-amino acid modification
1795	GO:0031401	positive regulation of protein modification process
1795	GO:0042127	regulation of cell proliferation
1795	GO:0051128	regulation of cellular component organization
1795	GO:2000026	regulation of multicellular organismal development

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1492	GO:0005634	nucleus
1492	GO:0005886	plasma membrane
1795	GO:0070013	intracellular organelle lumen
1795	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0008284	positive regulation of cell proliferation	IMP
GO:0009725	response to hormone	IDA
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO
GO:0030041	actin filament polymerization	IEA
GO:0030218	erythrocyte differentiation	IMP
GO:0030833	regulation of actin filament polymerization	ISO
GO:0030854	positive regulation of granulocyte differentiation	IMP
GO:0033138	positive regulation of peptidyl-serine phosphorylation	ISO
GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IMP

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Cellular Components

Showing 1 to 6 of 6 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005667	transcription factor complex	ISO
GO:0005737	cytoplasm	IDA
GO:0005739	mitochondrion	IEA
GO:0005829	cytosol	ISO
GO:0005886	plasma membrane	ISO

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005886	plasma membrane	1.90e-175	3.75e-40
GO:0005667	transcription factor complex	GO:0005737	cytoplasm	8.51e-03	3.68e-18
GO:0005667	transcription factor complex	GO:0005886	plasma membrane	6.81e-29	2.33e-66

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
H1BP3_MOUSE	No
LCK_MOUSE	No
LYN_MOUSE	Yes: P25911 (MoonDB)
NFE2_MOUSE	No

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Publications Associated

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PMID	Article Title
7535527	Molecular cloning and characterization of mouse HS1.
7628441	LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56(lck).
8943564	Distinct binding patterns of HS1 to the Src SH2 and SH3 domains reflect possible mechanisms of recruitment and activation of downstream molecules.
10590261	Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17947660	Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
19001085	Contributions of F-BAR and SH2 domains of Fes protein tyrosine kinase for coupling to the FcepsilonRI pathway in mast cells.
19064729	Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
21183079	A tissue-specific atlas of mouse protein phosphorylation and expression.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
CORTACTIN	PS51090	PROSITE
HS1	IPR028534	InterPro
Hs1_Cortactin	IPR003134	InterPro
HS1_rep	PF02218	Pfam
I49760	I49760	PIR
PTHR10829:SF5	PTHR10829:SF5	PANTHER
SH3	PS50002	PROSITE
SH3	SM00326	SMART
SH3-like_dom_sf	IPR036028	InterPro
SH3_1	PF00018	Pfam

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