Protein: P25911

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P25911 (Uniprot) LYN_MOUSE Lyn Tyrosine-protein kinase Lyn mouse No
Uniprot: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, PTK2B/PYK2, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1795 GO:0007165 signal transduction 1492 2.28e-48 1.95e-17
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1483 GO:0044267 cellular protein metabolic process
1483 GO:0035556 intracellular signal transduction
1483 GO:0016310 phosphorylation
1483 GO:0051128 regulation of cellular component organization
1483 GO:0060255 regulation of macromolecule metabolic process
1483 GO:0009966 regulation of signal transduction
1492 GO:0035556 intracellular signal transduction
1492 GO:0010646 regulation of cell communication
1492 GO:0060255 regulation of macromolecule metabolic process
1492 GO:0023051 regulation of signaling
1562 GO:0007165 signal transduction
1795 GO:0034645 cellular macromolecule biosynthetic process
1795 GO:0018193 peptidyl-amino acid modification
1795 GO:0031401 positive regulation of protein modification process
1795 GO:0042127 regulation of cell proliferation
1795 GO:0051128 regulation of cellular component organization
1795 GO:2000026 regulation of multicellular organismal development
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1483 GO:0005829 cytosol
1483 GO:0043232 intracellular non-membrane-bounded organelle
1483 GO:0005634 nucleus
1483 GO:0005886 plasma membrane
1483 GO:0031982 vesicle
1492 GO:0005634 nucleus
1492 GO:0005886 plasma membrane
1562 GO:0043232 intracellular non-membrane-bounded organelle
1562 GO:0005886 plasma membrane
1795 GO:0070013 intracellular organelle lumen
1795 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001782 B cell homeostasis IMP
GO:0001817 regulation of cytokine production IMP
GO:0001933 negative regulation of protein phosphorylation IMP
GO:0001934 positive regulation of protein phosphorylation ISO
GO:0002250 adaptive immune response IEA
GO:0002431 Fc receptor mediated stimulatory signaling pathway IMP
GO:0002513 tolerance induction to self antigen IMP
GO:0002553 histamine secretion by mast cell IEA
GO:0002576 platelet degranulation IMP
GO:0002762 negative regulation of myeloid leukocyte differentiation IMP
GO:0002768 immune response-regulating cell surface receptor signaling pathway IMP
GO:0002774 Fc receptor mediated inhibitory signaling pathway IMP
GO:0002902 regulation of B cell apoptotic process IMP
GO:0006468 protein phosphorylation ISO
GO:0006935 chemotaxis IBA
GO:0006974 cellular response to DNA damage stimulus ISO
GO:0006991 response to sterol depletion IEA
GO:0007165 signal transduction TAS
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway ISO
GO:0007417 central nervous system development IBA
GO:0008284 positive regulation of cell proliferation IMP
GO:0008285 negative regulation of cell proliferation IMP
GO:0009636 response to toxic substance IEA
GO:0009725 response to hormone IDA
GO:0009743 response to carbohydrate IEA
GO:0010976 positive regulation of neuron projection development ISO
GO:0014003 oligodendrocyte development IEA
GO:0014070 response to organic cyclic compound IEA
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:0030097 hemopoiesis IMP
GO:0030218 erythrocyte differentiation IMP
GO:0030335 positive regulation of cell migration IMP
GO:0030889 negative regulation of B cell proliferation IMP
GO:0031175 neuron projection development IMP
GO:0031663 lipopolysaccharide-mediated signaling pathway IMP
GO:0031668 cellular response to extracellular stimulus IEA
GO:0032868 response to insulin IEA
GO:0033003 regulation of mast cell activation IMP
GO:0033628 regulation of cell adhesion mediated by integrin ISO
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway IMP
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway IMP
GO:0034605 cellular response to heat IEA
GO:0035556 intracellular signal transduction IDA
GO:0038083 peptidyl-tyrosine autophosphorylation IBA
GO:0042493 response to drug IEA
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
GO:0042541 hemoglobin biosynthetic process TAS
GO:0043200 response to amino acid IEA
GO:0043304 regulation of mast cell degranulation IMP
GO:0043407 negative regulation of MAP kinase activity IMP
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
GO:0045087 innate immune response IEA
GO:0045646 regulation of erythrocyte differentiation IMP
GO:0046777 protein autophosphorylation IDA
GO:0048678 response to axon injury IEA
GO:0050663 cytokine secretion IEA
GO:0050707 regulation of cytokine secretion IMP
GO:0050727 regulation of inflammatory response IMP
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
GO:0050853 B cell receptor signaling pathway IDA
GO:0050855 regulation of B cell receptor signaling pathway IMP
GO:0050861 positive regulation of B cell receptor signaling pathway IGI
GO:0051272 positive regulation of cellular component movement ISO
GO:0051279 regulation of release of sequestered calcium ion into cytosol IGI
GO:0060252 positive regulation of glial cell proliferation IEA
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway IEA
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade ISO
GO:0070372 regulation of ERK1 and ERK2 cascade IMP
GO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation IEA
GO:0070667 negative regulation of mast cell proliferation IMP
GO:0070668 positive regulation of mast cell proliferation ISO
GO:0071300 cellular response to retinoic acid ISO
GO:0090025 regulation of monocyte chemotaxis ISO
GO:0090330 regulation of platelet aggregation IMP
GO:0097028 dendritic cell differentiation IMP
GO:1902532 negative regulation of intracellular signal transduction IMP
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
GO:2000670 positive regulation of dendritic cell apoptotic process IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005758 mitochondrial intermembrane space IEA
GO:0005794 Golgi apparatus ISO
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0005913 cell-cell adherens junction IEA
GO:0014069 postsynaptic density IEA
GO:0030061 mitochondrial crista IEA
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
GO:0034666 integrin alpha2-beta1 complex IEA
GO:0042629 mast cell granule IEA
GO:0043231 intracellular membrane-bounded organelle ISO
GO:0045121 membrane raft ISO
GO:0048471 perinuclear region of cytoplasm ISO
GO:0070062 extracellular exosome ISO
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005794 Golgi apparatus 1.45e-16 1.34e-03
GO:0005634 nucleus GO:0005886 plasma membrane 1.90e-175 3.75e-40
GO:0005634 nucleus GO:0070062 extracellular exosome 1.57e-02 1.76e-07
GO:0005886 plasma membrane GO:0043231 intracellular membrane-bounded organelle 5.51e-230 1.21e-17
PMID Article Title
1702903 Association of B cell antigen receptor with protein tyrosine kinase Lyn.
1710766 Alternatively spliced murine lyn mRNAs encode distinct proteins.
2017160 Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.
2482828 The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family.
7513017 Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
7584145 Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice.
7585947 Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease.
7782294 Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.
8128248 Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.
8168489 Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity.
8183901 Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha.
8530369 Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.
8621063 Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase.
8629002 Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.
9036984 Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.
9064343 Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice.
9252121 Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation.
9469421 Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation.
9480991 Inhibition of the B cell by CD22: a requirement for Lyn.
9547345 A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals.
9573010 Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.
9590210 The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation.
9601638 Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes.
10327049 Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.
10415030 CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells.
10594694 Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings.
10640270 Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.
10672044 Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis.
11007759 Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity.
11435302 Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells.
11517336 Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
11672542 Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
12077122 Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase.
12486102 Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.
12874221 The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling.
14525964 The Src kinase Lyn is a negative regulator of mast cell proliferation.
14726379 Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors.
15220000 Src-family kinases: rheostats of immune cell signaling.
15304502 Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl.
15335855 B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15489917 Src-family kinases in B-cell development and signaling.
15664155 Lyn tyrosine kinase: accentuating the positive and the negative.
16034130 Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity.
16116174 The Lyn tyrosine kinase differentially regulates dendritic cell generation and maturation.
16249387 LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
16272347 Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI.
16684964 Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
16731527 Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation.
17233630 Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets.
17640867 Leupaxin negatively regulates B cell receptor signaling.
18034455 Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
18984583 Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.
19064729 Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation.
19144319 The phagosomal proteome in interferon-gamma-activated macrophages.
19290919 Multiple roles of Lyn kinase in myeloid cell signaling and function.
19492092 Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase.
20189992 An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
20385881 Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1.
20644716 Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
22496641 CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex.
No results found.
Domain Name Domain ID Source
A39719 A39719 PIR
Prot_kinase_dom IPR000719 InterPro
SH2 IPR000980 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
SH3_domain IPR001452 InterPro
Tyr_kinase_AS IPR008266 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
Lyn_SH3 IPR035748 InterPro
Lyn_SH2 IPR035852 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
Pkinase_Tyr PF07714 Pfam
TYRKINASE PR00109 PRINTS
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
TyrKc SM00219 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SSF56112 SSF56112 SUPFAM
SH2_Src_Lyn cd10364 CDD
SH3_Lyn cd12004 CDD