Protein: P20338 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P20338 (Uniprot)	RAB4A_HUMAN	RAB4A	Ras-related protein Rab-4A	human	No

Protein Function

Uniprot: Protein transport. Probably involved in vesicular traffic (By similarity).

Showing 1 to 1 of 1 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0043170	macromolecule metabolic process	606	GO:0042886	amide transport	663	2.11e-04	2.73e-69

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MoonDB Network Modules

Biological Processes

Showing 1 to 8 of 8 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
249	GO:0060255	regulation of macromolecule metabolic process
606	GO:0019538	protein metabolic process
606	GO:0006355	regulation of transcription, DNA-templated
606	GO:0007165	signal transduction
606	GO:0006366	transcription from RNA polymerase II promoter
629	GO:0007165	signal transduction
663	GO:0015833	peptide transport
663	GO:0008104	protein localization

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Cellular Components

Showing 1 to 9 of 9 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
249	GO:0005829	cytosol
249	GO:0005634	nucleus
249	GO:0031982	vesicle
606	GO:0005829	cytosol
606	GO:0031981	nuclear lumen
629	GO:0005829	cytosol
629	GO:0031982	vesicle
663	GO:0005829	cytosol
663	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006661	phosphatidylinositol biosynthetic process	TAS
GO:0015031	protein transport	IEA
GO:0019882	antigen processing and presentation	IMP
GO:0030100	regulation of endocytosis	IBA
GO:0032482	Rab protein signal transduction	IEA
GO:0032781	positive regulation of ATPase activity	IEA

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Cellular Components

Showing 1 to 10 of 12 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005768	endosome	IBA
GO:0005829	cytosol	IEA
GO:0005886	plasma membrane	IEA
GO:0030659	cytoplasmic vesicle membrane	TAS
GO:0031901	early endosome membrane	TAS
GO:0031982	vesicle	IDA
GO:0032593	insulin-responsive compartment	IBA
GO:0043231	intracellular membrane-bounded organelle	IEA
GO:0048471	perinuclear region of cytoplasm	IDA
GO:0055038	recycling endosome membrane	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005886	plasma membrane	GO:0043231	intracellular membrane-bounded organelle	0.00e+00	3.79e-47

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All Protein Interactions

Showing 1 to 10 of 21 entries

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Interactor	Also a MoonDB EMF protein
APBB3_HUMAN	No
CD2AP_HUMAN	No
DC1L1_HUMAN	No
EXOC5_HUMAN	No
FA71C_HUMAN	No
GRAP1_HUMAN	No
HACE1_HUMAN	No
IDH3A_HUMAN	No
P53_HUMAN	Yes: P04637 (MoonDB)
PASK_HUMAN	Yes: Q96RG2 (MoonDB)

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Publications Associated

Showing 1 to 10 of 18 entries

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PMID	Article Title
1425574	Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle.
1902553	Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.
2501306	The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
10698684	Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles.
11786538	Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.
11788822	Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.
14617813	Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15280022	Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 8 of 8 entries

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Domain Name	Domain ID	Source
E34323	E34323	PIR
P-loop_NTPase	IPR027417	InterPro
RAB	PS51419	PROSITE
Ras	PF00071	Pfam
small_GTP	TIGR00231	TIGRFAMs
Small_GTP-bd_dom	IPR005225	InterPro
Small_GTPase	IPR001806	InterPro
SSF52540	SSF52540	SUPFAM

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