Protein: P20338

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P20338 (Uniprot) RAB4A_HUMAN RAB4A Ras-related protein Rab-4A human No
Uniprot: Protein transport. Probably involved in vesicular traffic (By similarity).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 606 GO:0042886 amide transport 663 2.11e-04 2.73e-69
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
249 GO:0060255 regulation of macromolecule metabolic process
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
629 GO:0007165 signal transduction
663 GO:0015833 peptide transport
663 GO:0008104 protein localization
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
629 GO:0005829 cytosol
629 GO:0031982 vesicle
663 GO:0005829 cytosol
663 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006661 phosphatidylinositol biosynthetic process TAS
GO:0015031 protein transport IEA
GO:0019882 antigen processing and presentation IMP
GO:0030100 regulation of endocytosis IBA
GO:0032482 Rab protein signal transduction IEA
GO:0032781 positive regulation of ATPase activity IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005768 endosome IBA
GO:0005829 cytosol IEA
GO:0005886 plasma membrane IEA
GO:0030659 cytoplasmic vesicle membrane TAS
GO:0031901 early endosome membrane TAS
GO:0031982 vesicle IDA
GO:0032593 insulin-responsive compartment IBA
GO:0043231 intracellular membrane-bounded organelle IEA
GO:0048471 perinuclear region of cytoplasm IDA
GO:0055038 recycling endosome membrane IEA
GO:0070062 extracellular exosome IDA
GO:0098837 postsynaptic recycling endosome IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005886 plasma membrane GO:0043231 intracellular membrane-bounded organelle 0.00e+00 3.79e-47
PMID Article Title
1425574 Reversible phosphorylation-dephosphorylation determines the localization of rab4 during the cell cycle.
1902553 Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2.
2501306 The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
10698684 Rabaptin4, a novel effector of the small GTPase rab4a, is recruited to perinuclear recycling vesicles.
11786538 Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein.
11788822 Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes.
14617813 Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15280022 Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15907487 High resolution crystal structures of human Rab4a in its active and inactive conformations.
16034420 Structural basis of family-wide Rab GTPase recognition by rabenosyn-5.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16935861 Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.
17786215 The N-Myc down regulated Gene1 (NDRG1) is a Rab4a effector involved in vesicular recycling of E-cadherin.
20098723 Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
E34323 E34323 PIR
Small_GTPase IPR001806 InterPro
Small_GTP-bd_dom IPR005225 InterPro
P-loop_NTPase IPR027417 InterPro
Ras PF00071 Pfam
RAB PS51419 PROSITE
SSF52540 SSF52540 SUPFAM
small_GTP TIGR00231 TIGRFAMs