Protein: Q96RG2

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q96RG2 (Uniprot) PASK_HUMAN PASK PAS domain-containing serine/threonine-protein kinase human No
Uniprot: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0043170 macromolecule metabolic process 412 GO:0042886 amide transport 663 2.11e-04 2.73e-69
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
178 GO:0060255 regulation of macromolecule metabolic process
178 GO:0007165 signal transduction
249 GO:0060255 regulation of macromolecule metabolic process
412 GO:0019538 protein metabolic process
412 GO:0060255 regulation of macromolecule metabolic process
663 GO:0015833 peptide transport
663 GO:0008104 protein localization
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
178 GO:0005634 nucleus
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
412 GO:0005829 cytosol
412 GO:0005634 nucleus
663 GO:0005829 cytosol
663 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006468 protein phosphorylation IDA
GO:0043576 regulation of respiratory gaseous exchange ISS
GO:0045719 negative regulation of glycogen biosynthetic process IDA
GO:0045727 positive regulation of translation TAS
GO:0046777 protein autophosphorylation IDA
GO:0070092 regulation of glucagon secretion ISS
GO:2000505 regulation of energy homeostasis ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8590280 Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
9110174 Large-scale concatenation cDNA sequencing.
11459942 PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.
12168954 Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
12377121 Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16275910 Control of mammalian glycogen synthase by PAS kinase.
17052199 Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells.
17344846 Patterns of somatic mutation in human cancer genomes.
17595531 Male germ cell expression of the PAS domain kinase PASKIN and its novel target eukaryotic translation elongation factor eEF1A1.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19189049 The PAS-domain kinase PASKIN: a new sensor in energy homeostasis.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20943661 Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.
21181396 Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion.
21418524 Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
PAS IPR000014 InterPro
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
PAS-like_dom_sf IPR035965 InterPro
Pkinase PF00069 Pfam
PAS_9 PF13426 Pfam
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
PAS PS50112 PROSITE
PAS SM00091 SMART
S_TKc SM00220 SMART
SSF55785 SSF55785 SUPFAM
SSF56112 SSF56112 SUPFAM
T17211 T17211 PIR
sensory_box TIGR00229 TIGRFAMs
PAS cd00130 CDD