Protein: P06243 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P06243 (Uniprot)	CDC7_YEAST	CDC7	Cell division control protein 7	yeast	No

Protein Function

Uniprot: Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis. Required for HTA1-HTB1 locus transcription repression.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1139	GO:0009056	catabolic process	1141	3.10e-17	2.99e-04

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1139	GO:0034645	cellular macromolecule biosynthetic process
1139	GO:0044271	cellular nitrogen compound biosynthetic process
1139	GO:0044267	cellular protein metabolic process
1141	GO:0044248	cellular catabolic process
1141	GO:1903047	mitotic cell cycle process
1141	GO:0090304	nucleic acid metabolic process
1141	GO:2000112	regulation of cellular macromolecule biosynthetic process
1141	GO:0010468	regulation of gene expression
1141	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1139	GO:0005634	nucleus
1141	GO:0044427	chromosomal part
1141	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000727	double-strand break repair via break-induced replication	IMP
GO:0001100	negative regulation of exit from mitosis	IPI
GO:0006270	DNA replication initiation	IMP
GO:0006279	premeiotic DNA replication	IMP
GO:0006468	protein phosphorylation	IDA
GO:0006909	phagocytosis	IBA
GO:0008360	regulation of cell shape	IBA
GO:0010673	positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle	IMP
GO:0018105	peptidyl-serine phosphorylation	IDA
GO:0018107	peptidyl-threonine phosphorylation	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000775	chromosome, centromeric region	IDA
GO:0000785	chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IBA
GO:0031431	Dbf4-dependent protein kinase complex	IPI

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000775	chromosome, centromeric region	GO:0005737	cytoplasm	2.93e-06	2.51e-08
GO:0000785	chromatin	GO:0005737	cytoplasm	4.24e-25	3.35e-30
GO:0005634	nucleus	GO:0005737	cytoplasm	5.14e-51	7.30e-86

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CDC53_YEAST	Yes: Q12018 (MoonDB)
DBF4_YEAST	Yes: P32325 (MoonDB)
DHH1_YEAST	No
IPMK_YEAST	No
MCM2_YEAST	No
OTC_YEAST	No
PTM1_YEAST	No
TEL2_YEAST	No
TSR3_YEAST	No
YCR2_YEAST	No

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Publications Associated

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PMID	Article Title
1865880	CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae.
2668893	Transcriptional analysis of the CDC7 protein kinase gene of Saccharomyces cerevisiae.
2850010	Characterisation of the CDC7 gene product of Saccharomyces cerevisiae as a protein kinase needed for the initiation of mitotic DNA synthesis.
3537706	Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae.
9169867	The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
14562106	Global analysis of protein expression in yeast.
18407956	A multidimensional chromatography technology for in-depth phosphoproteome analysis.
24374639	The reference genome sequence of Saccharomyces cerevisiae: Then and now.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A25228	A25228	PIR
Kinase-like_dom_sf	IPR011009	InterPro
Pkinase	PF00069	Pfam
Prot_kinase_dom	IPR000719	InterPro
PROTEIN_KINASE_DOM	PS50011	PROSITE
PROTEIN_KINASE_ST	PS00108	PROSITE
S_TKc	SM00220	SMART
Ser/Thr_kinase_AS	IPR008271	InterPro
SSF56112	SSF56112	SUPFAM

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