Protein: Q9Y4K3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9Y4K3 (Uniprot) TRAF6_HUMAN TRAF6 TNF receptor-associated factor 6 human No
Uniprot: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125, 359 GO:0009059 macromolecule biosynthetic process 62 6.37e-04 1.88e-40
GO:0007165 signal transduction 308 GO:0006139 nucleobase-containing compound metabolic process 444 1.10e-111 5.07e-25
GO:0044260 cellular macromolecule metabolic process 340 GO:0033036 macromolecule localization 517 4.56e-06 3.25e-28
GO:0006139 nucleobase-containing compound metabolic process 444 GO:0033036 macromolecule localization 517 4.58e-19 9.70e-72
GO:0033036 macromolecule localization 517 GO:0009059 macromolecule biosynthetic process 62 2.32e-08 6.09e-30
GO:0033036 macromolecule localization 517 GO:0043170 macromolecule metabolic process 606 2.48e-08 1.95e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
62 GO:0034645 cellular macromolecule biosynthetic process
62 GO:0090304 nucleic acid metabolic process
62 GO:1901362 organic cyclic compound biosynthetic process
62 GO:0060255 regulation of macromolecule metabolic process
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
131 GO:0070647 protein modification by small protein conjugation or removal
131 GO:0006355 regulation of transcription, DNA-templated
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
275 GO:0022607 cellular component assembly
275 GO:0006796 phosphate-containing compound metabolic process
275 GO:0060255 regulation of macromolecule metabolic process
275 GO:0007165 signal transduction
308 GO:0007166 cell surface receptor signaling pathway
308 GO:0071310 cellular response to organic substance
308 GO:0035556 intracellular signal transduction
308 GO:0043085 positive regulation of catalytic activity
308 GO:0031328 positive regulation of cellular biosynthetic process
308 GO:0010604 positive regulation of macromolecule metabolic process
308 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
308 GO:0009967 positive regulation of signal transduction
308 GO:0006468 protein phosphorylation
308 GO:0031399 regulation of protein modification process
308 GO:0006355 regulation of transcription, DNA-templated
309 GO:0048584 positive regulation of response to stimulus
309 GO:0060255 regulation of macromolecule metabolic process
309 GO:0007165 signal transduction
340 GO:0016070 RNA metabolic process
340 GO:0010467 gene expression
340 GO:0060255 regulation of macromolecule metabolic process
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
473 GO:0060255 regulation of macromolecule metabolic process
473 GO:0007165 signal transduction
487 GO:0006355 regulation of transcription, DNA-templated
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
606 GO:0019538 protein metabolic process
606 GO:0006355 regulation of transcription, DNA-templated
606 GO:0007165 signal transduction
606 GO:0006366 transcription from RNA polymerase II promoter
652 GO:0044267 cellular protein metabolic process
652 GO:0060255 regulation of macromolecule metabolic process
685 GO:0060255 regulation of macromolecule metabolic process
685 GO:0007165 signal transduction
832 GO:0060255 regulation of macromolecule metabolic process
832 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
62 GO:0005829 cytosol
62 GO:0005634 nucleus
125 GO:0005829 cytosol
125 GO:0005634 nucleus
131 GO:0005829 cytosol
131 GO:0043232 intracellular non-membrane-bounded organelle
131 GO:0005634 nucleus
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
275 GO:0043232 intracellular non-membrane-bounded organelle
275 GO:0005634 nucleus
308 GO:0005829 cytosol
308 GO:0070013 intracellular organelle lumen
308 GO:0044428 nuclear part
308 GO:0005886 plasma membrane
309 GO:0016021 integral component of membrane
309 GO:0005886 plasma membrane
340 GO:0005634 nucleus
359 GO:0005634 nucleus
444 GO:0005634 nucleus
473 GO:0005634 nucleus
487 GO:0005634 nucleus
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
549 GO:0005829 cytosol
549 GO:0005634 nucleus
606 GO:0005829 cytosol
606 GO:0031981 nuclear lumen
652 GO:0005829 cytosol
652 GO:0005634 nucleus
652 GO:0031982 vesicle
685 GO:0005829 cytosol
832 GO:0005829 cytosol
832 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0000187 activation of MAPK activity TAS
GO:0000209 protein polyubiquitination IDA
GO:0001503 ossification IEA
GO:0001843 neural tube closure IEA
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002224 toll-like receptor signaling pathway TAS
GO:0002726 positive regulation of T cell cytokine production IMP
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
GO:0006461 protein complex assembly IEA
GO:0006974 cellular response to DNA damage stimulus IEA
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
GO:0007250 activation of NF-kappaB-inducing kinase activity IMP
GO:0007254 JNK cascade TAS
GO:0016579 protein deubiquitination TAS
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
GO:0030316 osteoclast differentiation IEA
GO:0031293 membrane protein intracellular domain proteolysis TAS
GO:0031398 positive regulation of protein ubiquitination NAS
GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
GO:0032147 activation of protein kinase activity IDA
GO:0032743 positive regulation of interleukin-2 production IMP
GO:0034162 toll-like receptor 9 signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0042088 T-helper 1 type immune response IEA
GO:0042102 positive regulation of T cell proliferation IEA
GO:0042475 odontogenesis of dentin-containing tooth IEA
GO:0043011 myeloid dendritic cell differentiation IEA
GO:0043065 positive regulation of apoptotic process TAS
GO:0043066 negative regulation of apoptotic process TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
GO:0043507 positive regulation of JUN kinase activity NAS
GO:0045084 positive regulation of interleukin-12 biosynthetic process IEA
GO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
GO:0045453 bone resorption IEA
GO:0045672 positive regulation of osteoclast differentiation IDA
GO:0045892 negative regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter NAS
GO:0048468 cell development IEA
GO:0048661 positive regulation of smooth muscle cell proliferation IEA
GO:0050852 T cell receptor signaling pathway TAS
GO:0050870 positive regulation of T cell activation IC
GO:0051023 regulation of immunoglobulin secretion IEA
GO:0051091 positive regulation of DNA binding transcription factor activity IMP
GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
GO:0051865 protein autoubiquitination IDA
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
GO:0070498 interleukin-1-mediated signaling pathway IEA
GO:0070534 protein K63-linked ubiquitination IDA
GO:0070555 response to interleukin-1 IDA
GO:0071222 cellular response to lipopolysaccharide IDA
GO:2000679 positive regulation of transcription regulatory region DNA binding IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005811 lipid droplet ISS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0005938 cell cortex IEA
GO:0009898 cytoplasmic side of plasma membrane ISS
GO:0010008 endosome membrane TAS
GO:0035631 CD40 receptor complex ISS
GO:0043234 protein complex IDA
GO:0048471 perinuclear region of cytoplasm IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
PMID Article Title
8837778 TRAF6 is a signal transducer for interleukin-1.
9020361 MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
9374458 IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
9432981 Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway.
9642260 RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
9774460 The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor.
9774977 ASK1 is essential for JNK/SAPK activation by TRAF2.
9915784 Association of the p75 neurotrophin receptor with TRAF6.
10094049 The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
10346818 Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.
10383454 IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
10514511 TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.
10523862 Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1).
10635328 TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.
10764746 TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.
10908663 B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1.
10920205 T6BP, a TRAF6-interacting protein involved in IL-1 signaling.
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.
11460167 TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
11751921 A novel zinc finger protein that inhibits osteoclastogenesis and the function of tumor necrosis factor receptor-associated factor 6.
11960013 IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.
12140561 Distinct molecular mechanism for initiating TRAF6 signalling.
12459498 NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6.
12496252 Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
12721283 TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
12804775 Pellino2 activates the mitogen activated protein kinase pathway.
12874243 Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
14530355 Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like receptor signaling.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14739303 Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways.
14754897 ZNF216 is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation.
14982987 Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
15121867 TRAF family proteins link PKR with NF-kappa B activation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15870274 The LIM protein Ajuba influences interleukin-1-induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex.
16125763 Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.
16153868 VISA is an adapter protein required for virus-triggered IFN-beta Signaling.
16221674 FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling.
16286016 IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST 2 and induces T helper type 2-associated cytokines.
16378096 Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16951688 Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1.
17135271 Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation.
17327397 Structure, interactions, and dynamics of the RING domain from human TRAF6.
17449468 RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
18093978 Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification.
18347055 Lys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activation.
18758450 The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
19465916 E2 interaction and dimerization in the crystal structure of TRAF6.
19521662 WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway.
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains.
19713527 The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
20079715 NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.
21302310 Alternative splicing of CARMA2/CARD14 transcripts generates protein variants with differential effect on NF-kappaB activation and endoplasmic reticulum stress-induced cell death.
21813773 IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.
25736436 WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
25861989 TRAF family member-associated NF-kappaB activator (TANK) inhibits genotoxic nuclear factor kappaB activation by facilitating deubiquitinase USP10-dependent deubiquitination of TRAF6 ligase.
No results found.
Domain Name Domain ID Source
Znf_TRAF IPR001293 InterPro
Znf_RING IPR001841 InterPro
MATH/TRAF_dom IPR002083 InterPro
TRAF-like IPR008974 InterPro
TNF_rcpt--assoc_TRAF IPR012227 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
Znf_RING_CS IPR017907 InterPro
TRAF6 IPR027139 InterPro
TRAF6_MATH IPR037309 InterPro
zf-TRAF PF02176 Pfam
TRAF PIRSF015614 PIRSF
ZF_RING_1 PS00518 PROSITE
ZF_RING_2 PS50089 PROSITE
MATH PS50144 PROSITE
ZF_TRAF PS50145 PROSITE
PTHR10131:SF111 PTHR10131:SF111 PANTHER
S71821 S71821 PIR
MATH SM00061 SMART
RING SM00184 SMART
SSF49599 SSF49599 SUPFAM
MATH_TRAF6 cd03776 CDD