Protein: P99999 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P99999 (Uniprot)	CYC_HUMAN	CYCS	Cytochrome c	human	Yes

Protein Function

Uniprot: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport more..

Dissimilar Functions Manual Curation

Function 1: Electron transport protein. Condition: presence in mitochondrion.

Function 2: Activation of apoptosis by binding to Apaf-1 that triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Condition: release in the cytosol due to altered mitochondrial membrane permeability.

Publications (PMID): 12714060

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
340	GO:0016070	RNA metabolic process
340	GO:0010467	gene expression
340	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
340	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	TAS
GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	TAS
GO:0006470	protein dephosphorylation	IEA
GO:0007005	mitochondrion organization	TAS
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	TAS
GO:0034599	cellular response to oxidative stress	TAS
GO:0045333	cellular respiration	TAS
GO:0097193	intrinsic apoptotic signaling pathway	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000159	protein phosphatase type 2A complex	TAS
GO:0005634	nucleus	IDA
GO:0005739	mitochondrion	IDA
GO:0005743	mitochondrial inner membrane	TAS
GO:0005758	mitochondrial intermembrane space	TAS
GO:0005829	cytosol	TAS
GO:0070469	respiratory chain	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005743	mitochondrial inner membrane	GO:0005829	cytosol	6.20e-17	9.93e-03
GO:0005829	cytosol	GO:0070469	respiratory chain	3.52e-03	7.36e-07

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
B2CL1_HUMAN	No
CASP9_HUMAN	No
CBPC1_HUMAN	No
K1C40_HUMAN	No
MEOX2_HUMAN	Yes: P50222 (MoonDB)
NAF1_HUMAN	No
TRAF6_HUMAN	Yes: Q9Y4K3 (MoonDB)

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Publications Associated

Showing 1 to 10 of 15 entries

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PMID	Article Title
2849112	The human somatic cytochrome c gene: two classes of processed pseudogenes demarcate a period of rapid molecular evolution.
9515723	Cytochrome c in the apoptotic and antioxidant cascades.
12690205	Human chromosome 7: DNA sequence and biology.
12853948	The DNA sequence of human chromosome 7.
13933734	The amino acid sequence of human heart cytochrome c.
14063298	Human heart cytochrome c. Chymotryptic peptides, tryptic peptides, and the complete amino acid sequence.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17974005	The full-ORF clone resource of the German cDNA consortium.
18345000	A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.

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OMIM Diseases Associated

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OMIM ID	Disease Name
612004	Thrombocytopenia 4

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Protein Domains Associated

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Domain Name	Domain ID	Source
CCHU	A31764	PIR
Cyt_c-like_dom	IPR009056	InterPro
Cyt_c-like_dom_sf	IPR036909	InterPro
Cyt_c_1A/1B	IPR002327	InterPro
CYTC	PS51007	PROSITE
CYTCHRMECIAB	PR00604	PRINTS
Cytochrom_C	PF00034	Pfam
PTHR11961	PTHR11961	PANTHER
SSF46626	SSF46626	SUPFAM

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