Protein: Q9BPZ3

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9BPZ3 (Uniprot) PAIP2_HUMAN PAIP2 Polyadenylate-binding protein-interacting protein 2 human No
Uniprot: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 504 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
504 GO:0044271 cellular nitrogen compound biosynthetic process
504 GO:0044267 cellular protein metabolic process
504 GO:0031324 negative regulation of cellular metabolic process
504 GO:0010629 negative regulation of gene expression
504 GO:0051172 negative regulation of nitrogen compound metabolic process
504 GO:0051252 regulation of RNA metabolic process
504 GO:2000112 regulation of cellular macromolecule biosynthetic process
Module ID (MoonGO) GO ID (CC) GO Name
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
504 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007283 spermatogenesis IEA
GO:0007613 memory IEA
GO:0045947 negative regulation of translational initiation IDA
GO:1900271 regulation of long-term synaptic potentiation IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
PABP1_HUMAN Yes: P11940 (MoonDB)
PMID Article Title
11042152 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
11172725 Translational repression by a novel partner of human poly(A) binding protein, Paip2.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11287632 Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.
11438674 Dual interactions of the translational repressor Paip2 with poly(A) binding protein.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16804161 Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.
No results found.
Domain Name Domain ID Source
Ataxin-2_C IPR009818 InterPro
PAM2 PF07145 Pfam