Protein: Q95017

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q95017 (Uniprot) UBC9_CAEEL ubc-9 SUMO-conjugating enzyme UBC9 worm No
Uniprot: Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 2261 GO:0006139 nucleobase-containing compound metabolic process 2664 1.61e-11 3.68e-10
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
2261 GO:0044267 cellular protein metabolic process
2515 GO:0016070 RNA metabolic process
2664 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
2261 GO:0043232 intracellular non-membrane-bounded organelle
2261 GO:0005634 nucleus
2515 GO:0005634 nucleus
2664 GO:0005694 chromosome
2664 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0002119 nematode larval development IMP
GO:0009792 embryo development ending in birth or egg hatching IMP
GO:0009952 anterior/posterior pattern specification IMP
GO:0016925 protein sumoylation IMP
GO:0043282 pharyngeal muscle development IMP
GO:1903827 regulation of cellular protein localization IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IBA
GO:0005635 nuclear envelope IEA
GO:0005737 cytoplasm IBA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9851916 Genome sequence of the nematode C. elegans: a platform for investigating biology.
11806825 Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
14711411 BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.
15107848 SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
15689373 Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
15990876 Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
16701625 The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
24349540 An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.
25475837 Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.
No results found.
Domain Name Domain ID Source
UBQ-conjugat_E2 IPR000608 InterPro
UBQ-conjugating_enzyme/RWD IPR016135 InterPro
UBQ-conjugating_AS IPR023313 InterPro
Ubc9 IPR027230 InterPro
UQ_con PF00179 Pfam
UBIQUITIN_CONJUGAT_1 PS00183 PROSITE
UBIQUITIN_CONJUGAT_2 PS50127 PROSITE
PTHR43927 PTHR43927 PANTHER
SSF54495 SSF54495 SUPFAM
T29929 T29929 PIR
UBCc cd00195 CDD