Protein: Q95017 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q95017 (Uniprot)	UBC9_CAEEL	ubc-9	SUMO-conjugating enzyme UBC9	worm	No

Protein Function

Uniprot: Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vul more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	2261	GO:0006139	nucleobase-containing compound metabolic process	2664	1.61e-11	3.68e-10

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
2261	GO:0044267	cellular protein metabolic process
2515	GO:0016070	RNA metabolic process
2664	GO:0090304	nucleic acid metabolic process

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Cellular Components

Showing 1 to 5 of 5 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
2261	GO:0043232	intracellular non-membrane-bounded organelle
2261	GO:0005634	nucleus
2515	GO:0005634	nucleus
2664	GO:0005694	chromosome
2664	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IMP
GO:0002119	nematode larval development	IMP
GO:0009792	embryo development ending in birth or egg hatching	IMP
GO:0009952	anterior/posterior pattern specification	IMP
GO:0016925	protein sumoylation	IMP
GO:0043282	pharyngeal muscle development	IMP
GO:1903827	regulation of cellular protein localization	IMP

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IBA
GO:0005635	nuclear envelope	IEA
GO:0005737	cytoplasm	IBA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 13 entries

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Interactor	Also a MoonDB EMF protein
ARL13_CAEEL	No
BARD1_CAEEL	No
GEI17_CAEEL	No
GIP2_CAEEL	No
MEL26_CAEEL	Yes: Q94420 (MoonDB)
Q21747_CAEEL	No
Q23158_CAEEL	No
Q95Q25_CAEEL	No
Q9NA84_CAEEL	No
RGP2_CAEEL	No

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Publications Associated

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PMID	Article Title
9851916	Genome sequence of the nematode C. elegans: a platform for investigating biology.
11806825	Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
14711411	BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.
15107848	SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
15689373	Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
15990876	Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
16701625	The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
24349540	An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.
25475837	Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 11 entries

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Domain Name	Domain ID	Source
PTHR43927	PTHR43927	PANTHER
SSF54495	SSF54495	SUPFAM
T29929	T29929	PIR
Ubc9	IPR027230	InterPro
UBCc	cd00195	CDD
UBIQUITIN_CONJUGAT_1	PS00183	PROSITE
UBIQUITIN_CONJUGAT_2	PS50127	PROSITE
UBQ-conjugat_E2	IPR000608	InterPro
UBQ-conjugating_AS	IPR023313	InterPro
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro

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