Protein: Q94420 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q94420 (Uniprot)	MEL26_CAEEL	mel-26	Protein maternal effect lethal 26	worm	No

Protein Function

Uniprot: Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922). Controls degradation of microtubule severing protein mei-1 (PubMed:14528312). In body wall muscles, involved more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	2261	GO:0006139	nucleobase-containing compound metabolic process	2664	1.61e-11	3.68e-10

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
2261	GO:0044267	cellular protein metabolic process
2446	GO:0060255	regulation of macromolecule metabolic process
2557	GO:0016070	RNA metabolic process
2557	GO:0010467	gene expression
2557	GO:0060255	regulation of macromolecule metabolic process
2664	GO:0090304	nucleic acid metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
2261	GO:0043232	intracellular non-membrane-bounded organelle
2261	GO:0005634	nucleus
2557	GO:0005634	nucleus
2664	GO:0005694	chromosome
2664	GO:0044428	nuclear part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0030162	regulation of proteolysis	IBA
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	IBA
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0044257	cellular protein catabolic process	IMP
GO:0071688	striated muscle myosin thick filament assembly	IMP

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000793	condensed chromosome	IDA
GO:0005737	cytoplasm	IDA
GO:0005938	cell cortex	IDA
GO:0016020	membrane	IDA
GO:0019005	SCF ubiquitin ligase complex	IBA
GO:0031430	M band	IDA
GO:0031674	I band	IDA
GO:0032154	cleavage furrow	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 67 entries

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Interactor	Also a MoonDB EMF protein
A5JYT2_CAEEL	No
APC1_CAEEL	No
ARL13_CAEEL	No
B1Q240_CAEEL	No
CUL3_CAEEL	No
G5EBG1_CAEEL	No
G5EC23_CAEEL	No
G5EFI6_CAEEL	No
G5EFM8_CAEEL	No
G5EGE8_CAEEL	No

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Publications Associated

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PMID	Article Title
9725834	Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component.
9851916	Genome sequence of the nematode C. elegans: a platform for investigating biology.
13679922	BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
14528312	Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
22621901	UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 14 entries

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Domain Name	Domain ID	Source
BTB	PF00651	Pfam
BTB	PS50097	PROSITE
BTB	SM00225	SMART
BTB/POZ_dom	IPR000210	InterPro
MATH	PS50144	PROSITE
MATH	SM00061	SMART
MATH/TRAF_dom	IPR002083	InterPro
SKP1/BTB/POZ_sf	IPR011333	InterPro
SPOP_C	IPR034089	InterPro
SPOP_C	cd14734	CDD

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