Protein: Q92731

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q92731 (Uniprot) ESR2_HUMAN ESR2 Estrogen receptor beta human No
Uniprot: Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 169 GO:0006139 nucleobase-containing compound metabolic process 592 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
592 GO:0090304 nucleic acid metabolic process
592 GO:0034654 nucleobase-containing compound biosynthetic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
169 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
592 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0006355 regulation of transcription, DNA-templated TAS
GO:0006367 transcription initiation from RNA polymerase II promoter TAS
GO:0007165 signal transduction TAS
GO:0007267 cell-cell signaling TAS
GO:0030308 negative regulation of cell growth NAS
GO:0030520 intracellular estrogen receptor signaling pathway TAS
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0051091 positive regulation of DNA binding transcription factor activity IDA
GO:1900116 extracellular negative regulation of signal transduction IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region IEA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005739 mitochondrion IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
PMID Article Title
8769313 ER beta: identification and characterization of a novel human estrogen receptor.
9267036 Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
9325313 Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.
9473491 The complete primary structure of human estrogen receptor beta (hERbeta) and its heterodimerization with ER alpha in vivo and in vitro.
9636657 Cloning and characterization of human estrogen receptor beta isoforms.
9671811 Molecular cloning and characterization of human estrogen receptor beta cx: a potential inhibitor of estrogen action in human.
9685228 Estrogen receptor-beta mRNA variants in human and murine tissues.
10681503 Cloning and characterization of RAP250, a nuclear receptor coactivator.
10964723 Cloning and characterization of human estrogen receptor beta promoter.
11113208 CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant.
11579095 The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway.
12039952 Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
12415108 Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade.
12508121 The DNA sequence and analysis of human chromosome 14.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14759258 An unappreciated role for RNA surveillance.
15047147 ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor.
15199063 An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15862947 Selective hormone-dependent repression of estrogen receptor beta by a p38-activated ErbB2/ErbB3 pathway.
16938840 Estrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.
19126643 CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells.
20074560 Repression of estrogen receptor beta function by putative tumor suppressor DBC1.
No results found.
Domain Name Domain ID Source
Nucl_hrmn_rcpt_lig-bd IPR000536 InterPro
Znf_hrmn_rcpt IPR001628 InterPro
Nuclear_hrmn_rcpt IPR001723 InterPro
Znf_NHR/GATA IPR013088 InterPro
Estrogen_rcpt_beta_N IPR021064 InterPro
Oest_rcpt/oest-rel_rcp IPR024178 InterPro
ER-beta/gamma IPR028355 InterPro
NHR_like_dom_sf IPR035500 InterPro
JC5939 JC5939 PIR
Hormone_recep PF00104 Pfam
zf-C4 PF00105 Pfam
ERbeta_N PF12497 Pfam
ER-like_NR PIRSF002527 PIRSF
ER-b PIRSF500102 PIRSF
STROIDFINGER PR00047 PRINTS
STRDHORMONER PR00398 PRINTS
NUCLEAR_REC_DBD_1 PS00031 PROSITE
NUCLEAR_REC_DBD_2 PS51030 PROSITE
NR_LBD PS51843 PROSITE
PW0044 PW0044 PIR
S71400 S71400 PIR
ZnF_C4 SM00399 SMART
HOLI SM00430 SMART
SSF48508 SSF48508 SUPFAM