Protein: Q15024

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q15024 (Uniprot) EXOS7_HUMAN EXOSC7 Exosome complex component RRP42 human No
Uniprot: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006464 cellular protein modification process 375 GO:0016070 RNA metabolic process 719 5.81e-04 8.44e-05
Module ID (MoonGO) GO ID (BP) GO Name
375 GO:0070647 protein modification by small protein conjugation or removal
375 GO:0060255 regulation of macromolecule metabolic process
719 GO:0006401 RNA catabolic process
719 GO:0016071 mRNA metabolic process
719 GO:0010629 negative regulation of gene expression
719 GO:0019219 regulation of nucleobase-containing compound metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
375 GO:0005829 cytosol
375 GO:0005634 nucleus
719 GO:0005829 cytosol
719 GO:0043232 intracellular non-membrane-bounded organelle
719 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
GO:0006364 rRNA processing TAS
GO:0006401 RNA catabolic process NAS
GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' IBA
GO:0034473 U1 snRNA 3'-end processing IBA
GO:0034475 U4 snRNA 3'-end processing IBA
GO:0034476 U5 snRNA 3'-end processing IBA
GO:0043488 regulation of mRNA stability TAS
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
GO:0071028 nuclear mRNA surveillance IBA
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process IBA
GO:0071038 nuclear polyadenylation-dependent tRNA catabolic process IBA
GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process IBA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000176 nuclear exosome (RNase complex) IBA
GO:0000177 cytoplasmic exosome (RNase complex) IBA
GO:0000178 exosome (RNase complex) IDA
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IEA
GO:0005829 cytosol TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7788527 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.
11719186 AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.
11812149 Protein-protein interactions of hCsl4p with other human exosome subunits.
12419256 Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.
15231747 A protein interaction framework for human mRNA degradation.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16641997 The DNA sequence, annotation and analysis of human chromosome 3.
17174896 Reconstitution, activities, and structure of the eukaryotic RNA exosome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20531389 Dis3-like 1: a novel exoribonuclease associated with the human exosome.
21269460 Initial characterization of the human central proteome.
21876179 Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
ExoRNase_PH_dom1 IPR001247 InterPro
ExoRNase_PH_dom2 IPR015847 InterPro
Ribosomal_S5_D2-typ_fold IPR020568 InterPro
PNPase/RNase_PH_dom_sf IPR027408 InterPro
ExoRNase_PH_dom2_sf IPR036345 InterPro
RNase_PH PF01138 Pfam
RNase_PH_C PF03725 Pfam
SSF54211 SSF54211 SUPFAM
SSF55666 SSF55666 SUPFAM