Protein: P62310

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62310 (Uniprot) LSM3_HUMAN LSM3 U6 snRNA-associated Sm-like protein LSm3 human No
Uniprot: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 181 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
Module ID (MoonGO) GO ID (BP) GO Name
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
167 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
208 GO:0005634 nucleus
227 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006397 mRNA processing TAS
GO:0033962 cytoplasmic mRNA processing body assembly IBA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IBA
GO:0005634 nucleus TAS
GO:0005654 nucleoplasm TAS
GO:0005688 U6 snRNP IBA
GO:0005829 cytosol TAS
GO:0046540 U4/U6 x U5 tri-snRNP complex IBA
GO:0071011 precatalytic spliceosome IBA
GO:0071013 catalytic step 2 spliceosome IDA
GO:1990726 Lsm1-7-Pat1 complex IBA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10369684 Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.
10523320 A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
21269460 Initial characterization of the human central proteome.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
LSM_dom_euk/arc IPR001163 InterPro
LSM_dom_sf IPR010920 InterPro
Lsm3 IPR034105 InterPro
LSM PF01423 Pfam
Sm SM00651 SMART
SSF50182 SSF50182 SUPFAM
LSm3 cd01730 CDD