Protein: P48415 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P48415 (Uniprot)	SEC16_YEAST	SEC16	COPII coat assembly protein SEC16	yeast	No

Protein Function

Uniprot: Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	1004	GO:0016192	vesicle-mediated transport	1134	1.23e-52	1.21e-92

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1004	GO:0090304	nucleic acid metabolic process
1134	GO:0048193	Golgi vesicle transport
1134	GO:0022607	cellular component assembly
1134	GO:0034613	cellular protein localization
1134	GO:0051649	establishment of localization in cell
1134	GO:0043933	macromolecular complex subunit organization
1134	GO:0015031	protein transport

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1004	GO:0005634	nucleus
1134	GO:0005783	endoplasmic reticulum

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Protein GO Annotations

Biological Processes

Showing 1 to 4 of 4 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0015031	protein transport	IEA
GO:0016236	macroautophagy	IMP
GO:0048208	COPII vesicle coating	IDA
GO:0070973	protein localization to endoplasmic reticulum exit site	IMP

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000139	Golgi membrane	IEA
GO:0005789	endoplasmic reticulum membrane	IEA
GO:0012507	ER to Golgi transport vesicle membrane	IDA
GO:0070971	endoplasmic reticulum exit site	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 4 of 4 entries

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Interactor	Also a MoonDB EMF protein
SEC23_YEAST	Yes: P15303 (MoonDB)
SEC24_YEAST	No
SEC31_YEAST	No
SFB2_YEAST	No

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Publications Associated

Showing 1 to 10 of 18 entries

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PMID	Article Title
2188733	Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway.
7593161	Yeast SEC16 gene encodes a multidomain vesicle coat protein that interacts with Sec23p.
7593162	SED4 encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation.
9023343	Selective packaging of cargo molecules into endoplasmic reticulum-derived COPII vesicles.
9169875	The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
9325247	COPII subunit interactions in the assembly of the vesicle coat.
9880808	Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase.
10712514	Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae.
11694599	Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion.
12235121	Sec16p potentiates the action of COPII proteins to bud transport vesicles.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
ACE1-Sec16-like	cd09233	CDD
ACE1_Sec16_Sec31	IPR024298	InterPro
S61103	S61103	PIR
Sec16	IPR024880	InterPro
Sec16	PF12932	Pfam
Sec16_C	PF12931	Pfam
Sec16_CCD	IPR024340	InterPro
Sec16_N	IPR024468	InterPro
Sec16_N	PF12935	Pfam

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