Protein: P45973

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P45973 (Uniprot) CBX5_HUMAN CBX5 Chromobox protein homolog 5 human No
Uniprot: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 425 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
GO:0019538 protein metabolic process 545 GO:0016070 RNA metabolic process 689 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
425 GO:0006464 cellular protein modification process
461 GO:0034645 cellular macromolecule biosynthetic process
461 GO:0090304 nucleic acid metabolic process
461 GO:0034654 nucleobase-containing compound biosynthetic process
545 GO:0044267 cellular protein metabolic process
545 GO:0006139 nucleobase-containing compound metabolic process
559 GO:0006355 regulation of transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
732 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
425 GO:0005634 nucleus
461 GO:0043232 intracellular non-membrane-bounded organelle
461 GO:0005634 nucleus
545 GO:0005829 cytosol
545 GO:0005634 nucleus
545 GO:0031982 vesicle
559 GO:0031981 nuclear lumen
689 GO:0005654 nucleoplasm
732 GO:0043232 intracellular non-membrane-bounded organelle
732 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0007596 blood coagulation TAS
GO:0016032 viral process IEA
GO:0045892 negative regulation of transcription, DNA-templated IMP
GO:0070317 negative regulation of G0 to G1 transition TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000118 histone deacetylase complex ISS
GO:0000776 kinetochore IEA
GO:0000784 nuclear chromosome, telomeric region IDA
GO:0005634 nucleus IDA
GO:0005635 nuclear envelope TAS
GO:0005654 nucleoplasm TAS
GO:0005720 nuclear heterochromatin TAS
GO:0005721 pericentric heterochromatin ISS
GO:0005730 nucleolus IDA
GO:0010369 chromocenter IEA
GO:0016605 PML body IMP
GO:0017053 transcriptional repressor complex ISS
GO:0031618 nuclear pericentric heterochromatin NAS
GO:0032991 macromolecular complex IDA
GO:0035097 histone methyltransferase complex ISS
GO:1990904 ribonucleoprotein complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8505380 Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity.
8663349 Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1.
9169472 Domain-specific interactions of human HP1-type chromodomain proteins and inner nuclear membrane protein LBR.
10460410 Localization and phosphorylation of HP1 proteins during the cell cycle in mammalian cells.
11242053 Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
11313457 Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502821 A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.
15864296 Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles.
15882967 The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.
15899859 In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19617346 Physical and functional interaction between heterochromatin protein 1alpha and the RNA-binding protein heterogeneous nuclear ribonucleoprotein U.
19666599 Human BAHD1 promotes heterochromatic gene silencing.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19710015 The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor.
19783980 JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin.
19880879 ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1.
20042602 The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20498703 Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
20562864 Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.
20850016 Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.
21047797 Recognition and specificity determinants of the human cbx chromodomains.
21269460 Initial characterization of the human central proteome.
21346195 Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25772364 SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
25906157 A novel role of PRR14 in the regulation of skeletal myogenesis.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
G01808 G01808 PIR
Chromo/chromo_shadow_dom IPR000953 InterPro
Chromo_shadow_dom IPR008251 InterPro
Chromo-like_dom_sf IPR016197 InterPro
Chromo_dom_subgr IPR017984 InterPro
Chromodomain_CS IPR023779 InterPro
Chromo_domain IPR023780 InterPro
Chromo PF00385 Pfam
Chromo_shadow PF01393 Pfam
CHROMODOMAIN PR00504 PRINTS
CHROMO_1 PS00598 PROSITE
CHROMO_2 PS50013 PROSITE
CHROMO SM00298 SMART
ChSh SM00300 SMART
SSF54160 SSF54160 SUPFAM
CHROMO cd00024 CDD