Protein: O00204

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00204 (Uniprot) ST2B1_HUMAN SULT2B1 Sulfotransferase family cytosolic 2B member 1 human No
Uniprot: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 354 6.71e-28 7.52e-07
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
249 GO:0060255 regulation of macromolecule metabolic process
284 GO:0009966 regulation of signal transduction
354 GO:0090304 nucleic acid metabolic process
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
249 GO:0005829 cytosol
249 GO:0005634 nucleus
249 GO:0031982 vesicle
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
354 GO:0005634 nucleus
549 GO:0005829 cytosol
549 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000103 sulfate assimilation IEA
GO:0008202 steroid metabolic process IDA
GO:0008203 cholesterol metabolic process IMP
GO:0008285 negative regulation of cell proliferation IMP
GO:0045606 positive regulation of epidermal cell differentiation IMP
GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005737 cytoplasm TAS
GO:0005783 endoplasmic reticulum IEA
GO:0005829 cytosol TAS
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005783 endoplasmic reticulum 8.26e-33 3.22e-89
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
9799594 Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene.
12145317 Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.
12923182 Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16855051 Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylation.
21855633 Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity.
28575648 Mutations in SULT2B1 cause autosomal-recessive congenital ichthyosis in humans.
OMIM ID Disease Name
617571 Ichthyosis, congenital, autosomal recessive 14
Domain Name Domain ID Source
Sulfotransferase_dom IPR000863 InterPro
P-loop_NTPase IPR027417 InterPro
Sulfotransfer_1 PF00685 Pfam
SSF52540 SSF52540 SUPFAM