Protein: O00204 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O00204 (Uniprot)	ST2B1_HUMAN	SULT2B1	Sulfotransferase family cytosolic 2B member 1	human	No

Protein Function

Uniprot: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0010646	regulation of cell communication	284	GO:0006139	nucleobase-containing compound metabolic process	354	6.71e-28	7.52e-07

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
249	GO:0060255	regulation of macromolecule metabolic process
284	GO:0009966	regulation of signal transduction
354	GO:0090304	nucleic acid metabolic process
549	GO:0008219	cell death
549	GO:0070887	cellular response to chemical stimulus
549	GO:0033554	cellular response to stress
549	GO:0035556	intracellular signal transduction
549	GO:0031325	positive regulation of cellular metabolic process
549	GO:0010604	positive regulation of macromolecule metabolic process
549	GO:0051173	positive regulation of nitrogen compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
249	GO:0005829	cytosol
249	GO:0005634	nucleus
249	GO:0031982	vesicle
284	GO:0005829	cytosol
284	GO:0005886	plasma membrane
354	GO:0005634	nucleus
549	GO:0005829	cytosol
549	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000103	sulfate assimilation	IEA
GO:0008202	steroid metabolic process	IDA
GO:0008203	cholesterol metabolic process	IMP
GO:0008285	negative regulation of cell proliferation	IMP
GO:0045606	positive regulation of epidermal cell differentiation	IMP
GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	TAS
GO:0005783	endoplasmic reticulum	IEA
GO:0005829	cytosol	TAS
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005783	endoplasmic reticulum	8.26e-33	3.22e-89
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACYP2_HUMAN	No
AL2SB_HUMAN	No
DDT4L_HUMAN	Yes: Q96D03 (MoonDB)
KLHL8_HUMAN	No
PRIC3_HUMAN	No
PROP1_HUMAN	No
REL_HUMAN	No
SRP72_HUMAN	No
ST1A1_HUMAN	No
ST1B1_HUMAN	No

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Publications Associated

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PMID	Article Title
9799594	Human hydroxysteroid sulfotransferase SULT2B1: two enzymes encoded by a single chromosome 19 gene.
12145317	Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase.
12923182	Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16855051	Characterization of proline-serine-rich carboxyl terminus in human sulfotransferase 2B1b: immunogenicity, subcellular localization, kinetic properties, and phosphorylation.
21855633	Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity.
28575648	Mutations in SULT2B1 cause autosomal-recessive congenital ichthyosis in humans.

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OMIM Diseases Associated

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OMIM ID	Disease Name
617571	Ichthyosis, congenital, autosomal recessive 14

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Protein Domains Associated

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Domain Name	Domain ID	Source
P-loop_NTPase	IPR027417	InterPro
SSF52540	SSF52540	SUPFAM
Sulfotransfer_1	PF00685	Pfam
Sulfotransferase_dom	IPR000863	InterPro

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