Protein: Q9UBC2

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9UBC2 (Uniprot) EP15R_HUMAN EPS15L1 Epidermal growth factor receptor substrate 15-like 1 human Yes
Uniprot: Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Dissimilar Functions Manual Curation

Function 1: Involved in cell growth regulation. EGFR phosphorylation. Acts as a clathrin adapter required for post-Golgi trafficking. Condition: cytoplasm or cell membrane localisation.

Function 2: Transcription regulation. Condition: nuclear localisation (import due to its N-terminal domain, export LMB sensitive with interaction with CRM1).

Publications (PMID): 11777906, 11425879, 19814798

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
796 GO:0034645 cellular macromolecule biosynthetic process
796 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
796 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006897 endocytosis IEA
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS
GO:0061024 membrane organization TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0016020 membrane IDA
GO:0030132 clathrin coat of coated pit IEA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
PMID Article Title
9407958 eps15 and eps15R are essential components of the endocytic pathway.
9853615 Selection system for genes encoding nuclear-targeted proteins.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15057824 The DNA sequence and biology of human chromosome 19.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16159959 Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
18669648 A quantitative atlas of mitotic phosphorylation.
19262564 SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20448150 FCHo proteins are nucleators of clathrin-mediated endocytosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22484487 Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
22648170 The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
EH_dom IPR000261 InterPro
EF_hand_dom IPR002048 InterPro
EF-hand-dom_pair IPR011992 InterPro
EF_Hand_1_Ca_BS IPR018247 InterPro
EF-hand_4 PF12763 Pfam
EF_HAND_1 PS00018 PROSITE
EH PS50031 PROSITE
EF_HAND_2 PS50222 PROSITE
EH SM00027 SMART
EFh SM00054 SMART
SSF47473 SSF47473 SUPFAM