Protein: Q9NPI8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NPI8 (Uniprot) FANCF_HUMAN FANCF Fanconi anemia group F protein human No
Uniprot: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 462 6.88e-41 1.21e-84
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
462 GO:0090304 nucleic acid metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
462 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001541 ovarian follicle development IEA
GO:0007283 spermatogenesis IEA
GO:0008150 biological_process ND
GO:0016567 protein ubiquitination IEA
GO:0036297 interstrand cross-link repair TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0043240 Fanconi anaemia nuclear complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10615118 The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM.
11063725 The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG.
12724401 A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15502827 X-linked inheritance of Fanconi anemia complementation group B.
16116422 A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M.
17082180 Structural determinants of human FANCF protein that function in the assembly of a DNA damage signaling complex.
18550849 HES1 is a novel interactor of the Fanconi anemia core complex.
OMIM ID Disease Name
603467 Fanconi anemia complementation group F
Domain Name Domain ID Source
FANCF_met IPR025825 InterPro
FANCF IPR035428 InterPro
PD321645 PD321645 ProDom
FANCF PF11107 Pfam
PTHR14449 PTHR14449 PANTHER