Protein: Q9JL25

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9JL25 (Uniprot) RGS1_MOUSE Rgs1 Regulator of G-protein signaling 1 mouse No
Uniprot: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (PubMed:10779778). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006810 transport 1565 GO:0009059 macromolecule biosynthetic process 1675 1.20e-73 5.64e-54
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1565 GO:0046907 intracellular transport
1675 GO:0034645 cellular macromolecule biosynthetic process
1675 GO:0044271 cellular nitrogen compound biosynthetic process
1675 GO:0010467 gene expression
2024 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1565 GO:0005829 cytosol
1675 GO:0005829 cytosol
1675 GO:0005634 nucleus
2024 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007165 signal transduction ISO
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
GO:0009968 negative regulation of signal transduction IEA
GO:0043547 positive regulation of GTPase activity ISO
GO:0061737 leukotriene signaling pathway ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005737 cytoplasm IBA
GO:0005829 cytosol ISO
GO:0005886 plasma membrane TAS
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
EIF3G_MOUSE No
BICD2_MOUSE No
SKAP2_MOUSE No
PMID Article Title
10779778 RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072 The transcriptional landscape of the mammalian genome.
No results found.
Domain Name Domain ID Source
RGS IPR016137 InterPro
RGS_subdom1 IPR024066 InterPro
RGS1 IPR030409 InterPro
RGS_sf IPR036305 InterPro
RGS PF00615 Pfam
RGSPROTEIN PR01301 PRINTS
RGS PS50132 PROSITE
PTHR10845:SF34 PTHR10845:SF34 PANTHER
RGS SM00315 SMART
SSF48097 SSF48097 SUPFAM