Protein: Q9CR42

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9CR42 (Uniprot) ANKR1_MOUSE Ankrd1 Ankyrin repeat domain-containing protein 1 mouse No
Uniprot: May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 1456 GO:0048583 regulation of response to stimulus 2116 7.81e-03 6.10e-16
GO:0034641 cellular nitrogen compound metabolic process 1869 GO:0048583 regulation of response to stimulus 2116 3.00e-06 3.03e-16
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1429 GO:0045893 positive regulation of transcription, DNA-templated
1429 GO:0006357 regulation of transcription from RNA polymerase II promoter
1438 GO:0031325 positive regulation of cellular metabolic process
1438 GO:0010604 positive regulation of macromolecule metabolic process
1438 GO:0051173 positive regulation of nitrogen compound metabolic process
1438 GO:0006355 regulation of transcription, DNA-templated
1446 GO:0016070 RNA metabolic process
1446 GO:0071310 cellular response to organic substance
1446 GO:0010467 gene expression
1446 GO:0031325 positive regulation of cellular metabolic process
1446 GO:0010604 positive regulation of macromolecule metabolic process
1446 GO:0007165 signal transduction
1448 GO:0016070 RNA metabolic process
1448 GO:0034645 cellular macromolecule biosynthetic process
1448 GO:0044271 cellular nitrogen compound biosynthetic process
1448 GO:0010467 gene expression
1448 GO:0060255 regulation of macromolecule metabolic process
1456 GO:0019438 aromatic compound biosynthetic process
1456 GO:0071495 cellular response to endogenous stimulus
1456 GO:0071310 cellular response to organic substance
1456 GO:1901701 cellular response to oxygen-containing compound
1456 GO:1901362 organic cyclic compound biosynthetic process
1456 GO:0060255 regulation of macromolecule metabolic process
1456 GO:0009628 response to abiotic stimulus
1456 GO:0007165 signal transduction
1463 GO:0031325 positive regulation of cellular metabolic process
1463 GO:0010604 positive regulation of macromolecule metabolic process
1463 GO:0051173 positive regulation of nitrogen compound metabolic process
1463 GO:0006355 regulation of transcription, DNA-templated
1488 GO:0055008 cardiac muscle tissue morphogenesis
1488 GO:0071214 cellular response to abiotic stimulus
1488 GO:0070887 cellular response to chemical stimulus
1488 GO:0033554 cellular response to stress
1488 GO:0048589 developmental growth
1488 GO:0045445 myoblast differentiation
1488 GO:0045892 negative regulation of transcription, DNA-templated
1488 GO:0007399 nervous system development
1488 GO:0018193 peptidyl-amino acid modification
1488 GO:0051094 positive regulation of developmental process
1488 GO:0050714 positive regulation of protein secretion
1488 GO:0048584 positive regulation of response to stimulus
1488 GO:0045893 positive regulation of transcription, DNA-templated
1488 GO:0006461 protein complex assembly
1488 GO:0042981 regulation of apoptotic process
1488 GO:0050790 regulation of catalytic activity
1488 GO:0045595 regulation of cell differentiation
1488 GO:1902531 regulation of intracellular signal transduction
1488 GO:2000026 regulation of multicellular organismal development
1488 GO:0031399 regulation of protein modification process
1488 GO:0080134 regulation of response to stress
1488 GO:0051592 response to calcium ion
1488 GO:0035994 response to muscle stretch
1488 GO:0045214 sarcomere organization
1488 GO:0035914 skeletal muscle cell differentiation
1490 GO:0006357 regulation of transcription from RNA polymerase II promoter
1502 GO:0006355 regulation of transcription, DNA-templated
1609 GO:0048738 cardiac muscle tissue development
1609 GO:0071560 cellular response to transforming growth factor beta stimulus
1609 GO:0003007 heart morphogenesis
1609 GO:0007517 muscle organ development
1609 GO:0031324 negative regulation of cellular metabolic process
1609 GO:0010605 negative regulation of macromolecule metabolic process
1609 GO:0051172 negative regulation of nitrogen compound metabolic process
1609 GO:0045597 positive regulation of cell differentiation
1609 GO:0051130 positive regulation of cellular component organization
1609 GO:0051050 positive regulation of transport
1609 GO:0008104 protein localization
1609 GO:0060284 regulation of cell development
1609 GO:0080135 regulation of cellular response to stress
1609 GO:1902531 regulation of intracellular signal transduction
1609 GO:2000026 regulation of multicellular organismal development
1609 GO:0035994 response to muscle stretch
1609 GO:0048729 tissue morphogenesis
1643 GO:0031324 negative regulation of cellular metabolic process
1643 GO:0010605 negative regulation of macromolecule metabolic process
1643 GO:0051172 negative regulation of nitrogen compound metabolic process
1643 GO:0031325 positive regulation of cellular metabolic process
1643 GO:0010604 positive regulation of macromolecule metabolic process
1643 GO:0051173 positive regulation of nitrogen compound metabolic process
1643 GO:0006355 regulation of transcription, DNA-templated
1643 GO:0006366 transcription from RNA polymerase II promoter
1689 GO:0045893 positive regulation of transcription, DNA-templated
1689 GO:0006357 regulation of transcription from RNA polymerase II promoter
1715 GO:0031324 negative regulation of cellular metabolic process
1715 GO:0010605 negative regulation of macromolecule metabolic process
1715 GO:0051172 negative regulation of nitrogen compound metabolic process
1715 GO:0010628 positive regulation of gene expression
1715 GO:0042981 regulation of apoptotic process
1715 GO:0032268 regulation of cellular protein metabolic process
1715 GO:0009966 regulation of signal transduction
1715 GO:0006355 regulation of transcription, DNA-templated
1756 GO:0071310 cellular response to organic substance
1756 GO:0031324 negative regulation of cellular metabolic process
1756 GO:0010629 negative regulation of gene expression
1756 GO:0051172 negative regulation of nitrogen compound metabolic process
1756 GO:2000112 regulation of cellular macromolecule biosynthetic process
1756 GO:0006351 transcription, DNA-templated
1869 GO:0044271 cellular nitrogen compound biosynthetic process
1869 GO:0070887 cellular response to chemical stimulus
1869 GO:0010467 gene expression
1869 GO:0031324 negative regulation of cellular metabolic process
1869 GO:0031328 positive regulation of cellular biosynthetic process
1869 GO:0010557 positive regulation of macromolecule biosynthetic process
1869 GO:2000112 regulation of cellular macromolecule biosynthetic process
2116 GO:0080134 regulation of response to stress
2116 GO:0009628 response to abiotic stimulus
2116 GO:0032496 response to lipopolysaccharide
2116 GO:0014070 response to organic cyclic compound
2116 GO:0007165 signal transduction
2135 GO:0055008 cardiac muscle tissue morphogenesis
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1429 GO:0031981 nuclear lumen
1438 GO:0031981 nuclear lumen
1446 GO:0005634 nucleus
1448 GO:0031981 nuclear lumen
1456 GO:0098588 bounding membrane of organelle
1456 GO:0031410 cytoplasmic vesicle
1456 GO:0012505 endomembrane system
1456 GO:0043233 organelle lumen
1456 GO:0005886 plasma membrane
1456 GO:0012506 vesicle membrane
1463 GO:0005634 nucleus
1488 GO:0030018 Z disc
1488 GO:0005829 cytosol
1488 GO:0031981 nuclear lumen
1490 GO:0031981 nuclear lumen
1502 GO:0005634 nucleus
1609 GO:0031674 I band
1643 GO:0043232 intracellular non-membrane-bounded organelle
1643 GO:0005654 nucleoplasm
1689 GO:0043232 intracellular non-membrane-bounded organelle
1689 GO:0005654 nucleoplasm
1715 GO:0031981 nuclear lumen
1756 GO:0005829 cytosol
1756 GO:0005730 nucleolus
1869 GO:0005829 cytosol
1869 GO:0043232 intracellular non-membrane-bounded organelle
1869 GO:0031981 nuclear lumen
2135 GO:0031674 I band
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA
GO:0010976 positive regulation of neuron projection development IEA
GO:0035690 cellular response to drug IDA
GO:0035914 skeletal muscle cell differentiation IMP
GO:0035994 response to muscle stretch ISO
GO:0043065 positive regulation of apoptotic process ISO
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
GO:0045445 myoblast differentiation IBA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:0050714 positive regulation of protein secretion ISO
GO:0055008 cardiac muscle tissue morphogenesis ISO
GO:0071222 cellular response to lipopolysaccharide IDA
GO:0071260 cellular response to mechanical stimulus ISO
GO:0071347 cellular response to interleukin-1 ISO
GO:0071356 cellular response to tumor necrosis factor ISO
GO:0071407 cellular response to organic cyclic compound IEA
GO:0071456 cellular response to hypoxia IEA
GO:0071560 cellular response to transforming growth factor beta stimulus ISO
GO:2000279 negative regulation of DNA biosynthetic process ISO
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0001650 fibrillar center ISO
GO:0005634 nucleus IDA
GO:0005667 transcription factor complex IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol ISO
GO:0030016 myofibril IDA
GO:0031674 I band IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005667 transcription factor complex GO:0005737 cytoplasm 8.51e-03 3.68e-18
PMID Article Title
9043061 CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
9278441 A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072 The transcriptional landscape of the mammalian genome.
No results found.
Domain Name Domain ID Source
Ankyrin_rpt IPR002110 InterPro
Ankyrin_rpt-contain_dom IPR020683 InterPro
Ankyrin_rpt-contain_sf IPR036770 InterPro
Ank_2 PF12796 Pfam
ANK_REPEAT PS50088 PROSITE
ANK_REP_REGION PS50297 PROSITE
ANK SM00248 SMART
SSF48403 SSF48403 SUPFAM
ANK cd00204 CDD