Protein: Q9BQB6

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9BQB6 (Uniprot) VKOR1_HUMAN VKORC1 Vitamin K epoxide reductase complex subunit 1 human No
Uniprot: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 161 GO:0007165 signal transduction 486 1.10e-111 5.07e-25
GO:0034641 cellular nitrogen compound metabolic process 477 GO:0007165 signal transduction 486 4.22e-144 6.90e-18
GO:0007165 signal transduction 486 GO:0006725 cellular aromatic compound metabolic process 81 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
8 GO:0008219 cell death
8 GO:0019538 protein metabolic process
8 GO:0007165 signal transduction
25 GO:0006464 cellular protein modification process
25 GO:0010467 gene expression
25 GO:0060255 regulation of macromolecule metabolic process
25 GO:0007165 signal transduction
81 GO:0006139 nucleobase-containing compound metabolic process
122 GO:0016070 RNA metabolic process
122 GO:0044271 cellular nitrogen compound biosynthetic process
122 GO:0006464 cellular protein modification process
122 GO:0031324 negative regulation of cellular metabolic process
122 GO:0010605 negative regulation of macromolecule metabolic process
122 GO:0051172 negative regulation of nitrogen compound metabolic process
122 GO:2000112 regulation of cellular macromolecule biosynthetic process
122 GO:0010468 regulation of gene expression
122 GO:0019219 regulation of nucleobase-containing compound metabolic process
122 GO:0007165 signal transduction
161 GO:0090304 nucleic acid metabolic process
212 GO:0007165 signal transduction
214 GO:0044267 cellular protein metabolic process
214 GO:0006355 regulation of transcription, DNA-templated
261 GO:0006355 regulation of transcription, DNA-templated
283 GO:0006464 cellular protein modification process
283 GO:0060255 regulation of macromolecule metabolic process
306 GO:0044267 cellular protein metabolic process
306 GO:0060255 regulation of macromolecule metabolic process
306 GO:0007165 signal transduction
362 GO:0006464 cellular protein modification process
362 GO:0060255 regulation of macromolecule metabolic process
429 GO:0016070 RNA metabolic process
429 GO:0034645 cellular macromolecule biosynthetic process
429 GO:0044271 cellular nitrogen compound biosynthetic process
429 GO:0019538 protein metabolic process
429 GO:0010468 regulation of gene expression
429 GO:0010556 regulation of macromolecule biosynthetic process
429 GO:0019219 regulation of nucleobase-containing compound metabolic process
430 GO:0019538 protein metabolic process
431 GO:0019538 protein metabolic process
431 GO:0060255 regulation of macromolecule metabolic process
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
456 GO:0010467 gene expression
456 GO:0090304 nucleic acid metabolic process
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
486 GO:0007166 cell surface receptor signaling pathway
486 GO:0006464 cellular protein modification process
486 GO:0060255 regulation of macromolecule metabolic process
508 GO:0007165 signal transduction
559 GO:0006355 regulation of transcription, DNA-templated
752 GO:0016070 RNA metabolic process
752 GO:0034645 cellular macromolecule biosynthetic process
752 GO:0044267 cellular protein metabolic process
752 GO:0034654 nucleobase-containing compound biosynthetic process
752 GO:0010468 regulation of gene expression
759 GO:0016070 RNA metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
8 GO:0012505 endomembrane system
8 GO:0016021 integral component of membrane
25 GO:0005829 cytosol
25 GO:0005634 nucleus
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
85 GO:0016021 integral component of membrane
122 GO:0005829 cytosol
122 GO:0043232 intracellular non-membrane-bounded organelle
122 GO:0005654 nucleoplasm
161 GO:0005634 nucleus
168 GO:0012505 endomembrane system
168 GO:0016021 integral component of membrane
174 GO:0016021 integral component of membrane
179 GO:0012505 endomembrane system
214 GO:0044428 nuclear part
261 GO:0031981 nuclear lumen
283 GO:0012505 endomembrane system
283 GO:0044428 nuclear part
306 GO:0070062 extracellular exosome
349 GO:0016021 integral component of membrane
350 GO:0012505 endomembrane system
350 GO:0031224 intrinsic component of membrane
362 GO:0070013 intracellular organelle lumen
362 GO:0005634 nucleus
429 GO:0070013 intracellular organelle lumen
429 GO:0005634 nucleus
431 GO:0005829 cytosol
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
486 GO:0005829 cytosol
486 GO:0005634 nucleus
486 GO:0031982 vesicle
501 GO:0031090 organelle membrane
508 GO:0016021 integral component of membrane
559 GO:0031981 nuclear lumen
687 GO:0031981 nuclear lumen
752 GO:0005829 cytosol
752 GO:0005654 nucleoplasm
759 GO:0031981 nuclear lumen
799 GO:0012505 endomembrane system
799 GO:0016021 integral component of membrane
817 GO:0070013 intracellular organelle lumen
817 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007596 blood coagulation IMP
GO:0017144 drug metabolic process IMP
GO:0017187 peptidyl-glutamic acid carboxylation IMP
GO:0042373 vitamin K metabolic process TAS
GO:0055114 oxidation-reduction process IEA
GO:0060348 bone development ISS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005789 endoplasmic reticulum membrane TAS
GO:0016021 integral component of membrane IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
12975309 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14765194 Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
14765195 Identification of the gene for vitamin K epoxide reductase.
15276181 Vitamin K epoxide reductase: homology, active site and catalytic mechanism.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553 The sequence and analysis of duplication-rich human chromosome 16.
15716279 Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.
15879509 The genetic basis of resistance to anticoagulants in rodents.
16270630 Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.
20696932 Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners.
20946155 Thirteen novel VKORC1 mutations associated with oral anticoagulant resistance: insights into improved patient diagnosis and treatment.
20978134 Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation.
22923610 Human vitamin K epoxide reductase and its bacterial homologue have different membrane topologies and reaction mechanisms.
24406068 Membrane topology for human vitamin K epoxide reductase.
OMIM ID Disease Name
122700 Coumarin resistance
607473 Combined deficiency of vitamin K-dependent clotting factors 2
Domain Name Domain ID Source
VKOR IPR012932 InterPro
VKOR PF07884 Pfam
VKc SM00756 SMART