Protein: Q9BQB6 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9BQB6 (Uniprot)	VKOR1_HUMAN	VKORC1	Vitamin K epoxide reductase complex subunit 1	human	No

Protein Function

Uniprot: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, b more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	161	GO:0007165	signal transduction	486	1.10e-111	5.07e-25
GO:0007165	signal transduction	486	GO:0006725	cellular aromatic compound metabolic process	81	5.44e-126	5.27e-27
GO:0034641	cellular nitrogen compound metabolic process	477	GO:0007165	signal transduction	486	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
8	GO:0008219	cell death
8	GO:0019538	protein metabolic process
8	GO:0007165	signal transduction
25	GO:0006464	cellular protein modification process
25	GO:0010467	gene expression
25	GO:0060255	regulation of macromolecule metabolic process
25	GO:0007165	signal transduction
81	GO:0006139	nucleobase-containing compound metabolic process
122	GO:0016070	RNA metabolic process
122	GO:0044271	cellular nitrogen compound biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
8	GO:0012505	endomembrane system
8	GO:0016021	integral component of membrane
25	GO:0005829	cytosol
25	GO:0005634	nucleus
65	GO:0012505	endomembrane system
65	GO:0016021	integral component of membrane
81	GO:0005829	cytosol
81	GO:0031981	nuclear lumen
85	GO:0016021	integral component of membrane
122	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0007596	blood coagulation	IMP
GO:0017144	drug metabolic process	IMP
GO:0017187	peptidyl-glutamic acid carboxylation	IMP
GO:0042373	vitamin K metabolic process	TAS
GO:0055114	oxidation-reduction process	IEA
GO:0060348	bone development	ISS

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Cellular Components

Showing 1 to 2 of 2 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0016021	integral component of membrane	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 10 of 83 entries

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Interactor	Also a MoonDB EMF protein
A1AT_HUMAN	No
APLP2_HUMAN	No
APOA1_HUMAN	No
APOA2_HUMAN	No
APOC1_HUMAN	No
APOC3_HUMAN	No
APOC4_HUMAN	No
ASGR1_HUMAN	No
ASGR2_HUMAN	No
AT5G3_HUMAN	No

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Publications Associated

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PMID	Article Title
12975309	The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
14765194	Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
14765195	Identification of the gene for vitamin K epoxide reductase.
15276181	Vitamin K epoxide reductase: homology, active site and catalytic mechanism.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15616553	The sequence and analysis of duplication-rich human chromosome 16.
15716279	Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation.
15879509	The genetic basis of resistance to anticoagulants in rodents.
16270630	Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.

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OMIM Diseases Associated

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OMIM ID	Disease Name
122700	Coumarin resistance
607473	Combined deficiency of vitamin K-dependent clotting factors 2

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Protein Domains Associated

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Domain Name	Domain ID	Source
VKc	SM00756	SMART
VKOR	IPR012932	InterPro
VKOR	PF07884	Pfam

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