Protein: Q60591 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q60591 (Uniprot)	NFAC2_MOUSE	Nfatc2	Nuclear factor of activated T-cells, cytoplasmic 2	mouse	No

Protein Function

Uniprot: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.

MoonDB Dissimilar Functions

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009059	macromolecule biosynthetic process	1701	GO:0007165	signal transduction	1917	2.28e-48	1.95e-17

Previous1Next

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 24 entries

Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
1437	GO:0035556	intracellular signal transduction
1437	GO:0010604	positive regulation of macromolecule metabolic process
1437	GO:0051173	positive regulation of nitrogen compound metabolic process
1437	GO:0048584	positive regulation of response to stimulus
1437	GO:0006357	regulation of transcription from RNA polymerase II promoter
1462	GO:0044267	cellular protein metabolic process
1462	GO:0031325	positive regulation of cellular metabolic process
1462	GO:0010604	positive regulation of macromolecule metabolic process
1462	GO:0051173	positive regulation of nitrogen compound metabolic process
1462	GO:0006357	regulation of transcription from RNA polymerase II promoter

Previous1 2 3Next

Cellular Components

Showing 1 to 6 of 6 entries

Search:

Module ID (MoonGO)	GO ID (CC)	GO Name
1437	GO:0005829	cytosol
1462	GO:0005654	nucleoplasm
1701	GO:0044454	nuclear chromosome part
1701	GO:0005654	nucleoplasm
1711	GO:0005634	nucleus
1929	GO:0005634	nucleus

Previous1Next

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 14 entries

Search:

GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IDA
GO:0001816	cytokine production	IDA
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0006974	cellular response to DNA damage stimulus	ISO
GO:0010628	positive regulation of gene expression	IMP
GO:0014904	myotube cell development	IMP
GO:0016477	cell migration	ISO
GO:0030890	positive regulation of B cell proliferation	ISO
GO:0033173	calcineurin-NFAT signaling cascade	IGI
GO:0042493	response to drug	ISO

Previous1 2Next

Cellular Components

Showing 1 to 8 of 8 entries

Search:

GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	IPI
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0030529	intracellular ribonucleoprotein complex	IDA
GO:0044798	nuclear transcription factor complex	IDA

Previous1Next

Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

Search:

GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005667	transcription factor complex	GO:0005737	cytoplasm	8.51e-03	3.68e-18

Previous1Next

All Protein Interactions

Showing 1 to 8 of 8 entries

Search:

Interactor	Also a MoonDB EMF protein
AN32A_MOUSE	No
CAN2_MOUSE	No
DPOD2_MOUSE	No
IRF5_MOUSE	No
LITAF_MOUSE	No
NOTC4_MOUSE	No
Q8BUN3_MOUSE	No
Q9Z1A1_MOUSE	No

Previous1Next

Publications Associated

Showing 1 to 10 of 12 entries

Search:

PMID	Article Title
7876165	A similar DNA-binding motif in NFAT family proteins and the Rel homology region.
8235597	Isolation of the cyclosporin-sensitive T cell transcription factor NFATp.
8668213	Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes.
8943202	NF-AT-driven interleukin-4 transcription potentiated by NIP45.
9660947	Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.
10089876	Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.
11030334	Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity.
11278367	Identification and characterization of a novel nuclear factor of activated T-cells-1 isoform expressed in mouse brain.
18675896	Alternative splicing and expression of human and mouse NFAT genes.
19468303	Lineage-specific biology revealed by a finished genome assembly of the mouse.

Previous1 2Next

OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 17 entries

Search:

Domain Name	Domain ID	Source
A48753	A48753	PIR
Ig-like_fold	IPR013783	InterPro
Ig_E-set	IPR014756	InterPro
IPT	SM00429	SMART
IPT_dom	IPR002909	InterPro
NFAT	IPR008366	InterPro
NUCFACTORATC	PR01789	PRINTS
p53-like_TF_DNA-bd	IPR008967	InterPro
PTHR12533	PTHR12533	PANTHER
REL_2	PS50254	PROSITE

Previous1 2Next