Protein: Q13492

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q13492 (Uniprot) PICAL_HUMAN PICALM Phosphatidylinositol-binding clathrin assembly protein human Yes
Uniprot: Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. more..
Dissimilar Functions Manual Curation

Function 1: Endocytic function. Assembly protein recruiting clathrin and AP2 to cell membranes.

Function 2: Activation of transcription in Gal4 assay via its TAD domain. Condition: nuclear localisation (nuclear import via interaction with CATS transcription factor, export via interaction with CRM1).

Publications (PMID): 16491119, 11425879

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006461 protein complex assembly TAS
GO:0006898 receptor-mediated endocytosis IDA
GO:0007409 axonogenesis IEA
GO:0007611 learning or memory ISS
GO:0008283 cell proliferation IMP
GO:0010629 negative regulation of gene expression IMP
GO:0016050 vesicle organization IMP
GO:0016188 synaptic vesicle maturation ISS
GO:0016192 vesicle-mediated transport TAS
GO:0016197 endosomal transport IMP
GO:0030097 hemopoiesis IEA
GO:0030100 regulation of endocytosis IMP
GO:0031623 receptor internalization IMP
GO:0032880 regulation of protein localization IDA
GO:0035459 cargo loading into vesicle IMP
GO:0043547 positive regulation of GTPase activity IMP
GO:0045056 transcytosis IMP
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0048261 negative regulation of receptor-mediated endocytosis IDA
GO:0048268 clathrin coat assembly IMP
GO:0048813 dendrite morphogenesis IEA
GO:0055072 iron ion homeostasis IMP
GO:0061024 membrane organization TAS
GO:0072583 clathrin-dependent endocytosis IMP
GO:0090647 modulation of age-related behavioral decline ISS
GO:0097494 regulation of vesicle size IMP
GO:0097753 membrane bending IMP
GO:0098711 iron ion import across plasma membrane IMP
GO:1900223 positive regulation of amyloid-beta clearance ISS
GO:1901216 positive regulation of neuron death IMP
GO:1902003 regulation of amyloid-beta formation ISS
GO:1902004 positive regulation of amyloid-beta formation TAS
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISS
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process ISS
GO:1903077 negative regulation of protein localization to plasma membrane IMP
GO:2000009 negative regulation of protein localization to cell surface IMP
GO:2000370 positive regulation of clathrin-dependent endocytosis NAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005769 early endosome IDA
GO:0005794 Golgi apparatus IEA
GO:0005829 cytosol TAS
GO:0005905 clathrin-coated pit IMP
GO:0009986 cell surface IDA
GO:0016020 membrane IDA
GO:0030122 AP-2 adaptor complex IDA
GO:0030132 clathrin coat of coated pit IDA
GO:0030136 clathrin-coated vesicle IMP
GO:0031224 intrinsic component of membrane ISS
GO:0031982 vesicle ISS
GO:0042734 presynaptic membrane ISS
GO:0043025 neuronal cell body IDA
GO:0043231 intracellular membrane-bounded organelle IDA
GO:0045211 postsynaptic membrane ISS
GO:0045334 clathrin-coated endocytic vesicle NAS
GO:0048471 perinuclear region of cytoplasm ISS
GO:0070381 endosome to plasma membrane transport vesicle IDA
GO:0097418 neurofibrillary tangle IMP
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005794 Golgi apparatus 4.39e-25 2.14e-64
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0030136 clathrin-coated vesicle 6.14e-04 7.94e-24
GO:0005634 nucleus GO:0031224 intrinsic component of membrane 0.00e+00 0.00e+00
GO:0005634 nucleus GO:0031982 vesicle 1.94e-54 3.27e-93
GO:0005634 nucleus GO:0045211 postsynaptic membrane 4.18e-05 1.09e-18
GO:0005634 nucleus GO:0045334 clathrin-coated endocytic vesicle 6.29e-03 1.54e-23
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
GO:0005829 cytosol GO:0031224 intrinsic component of membrane 0.00e+00 0.00e+00
GO:0009986 cell surface GO:0043231 intracellular membrane-bounded organelle 1.41e-26 4.81e-14
GO:0031224 intrinsic component of membrane GO:0043231 intracellular membrane-bounded organelle 2.52e-160 5.94e-80
GO:0043231 intracellular membrane-bounded organelle GO:0045211 postsynaptic membrane 8.76e-11 1.68e-02
PMID Article Title
8643484 The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
9737689 Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.
10436022 Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16491119 The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25944712 N-terminome analysis of the human mitochondrial proteome.
No results found.
Domain Name Domain ID Source
ENTH_VHS IPR008942 InterPro
ANTH_dom IPR011417 InterPro
ENTH IPR013809 InterPro
Clathrin_AP_dom2 IPR014712 InterPro
PICALM IPR030412 InterPro
ANTH PF07651 Pfam
ENTH PS50942 PROSITE
PTHR22951:SF16 PTHR22951:SF16 PANTHER
ENTH SM00273 SMART
SSF48464 SSF48464 SUPFAM