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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q06208
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q06208 (Uniprot)
RIF2_YEAST
RIF2
Protein RIF2
yeast
No
Protein Function
Uniprot:
Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and
in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.
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MoonDB Dissimilar Functions
Showing 1 to 2 of 2 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0009059
macromolecule biosynthetic process
1121
,
1144
GO:0033036
macromolecule localization
1156
3.71e-18
5.96e-60
GO:0044260
cellular macromolecule metabolic process
1063
,
1123
GO:0033036
macromolecule localization
1156
1.18e-20
4.59e-11
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 24 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
921
GO:0034645
cellular macromolecule biosynthetic process
921
GO:0044271
cellular nitrogen compound biosynthetic process
921
GO:0090304
nucleic acid metabolic process
962
GO:0006139
nucleobase-containing compound metabolic process
979
GO:0006139
nucleobase-containing compound metabolic process
1019
GO:0034314
Arp2/3 complex-mediated actin nucleation
1059
GO:0090304
nucleic acid metabolic process
1063
GO:0016070
RNA metabolic process
1063
GO:0034645
cellular macromolecule biosynthetic process
1063
GO:0010467
gene expression
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Cellular Components
Showing 1 to 10 of 19 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
921
GO:0005634
nucleus
960
GO:0005634
nucleus
982
GO:0043232
intracellular non-membrane-bounded organelle
982
GO:0005634
nucleus
986
GO:0016021
integral component of membrane
1019
GO:0030479
actin cortical patch
1059
GO:0005634
nucleus
1063
GO:0070013
intracellular organelle lumen
1063
GO:0005634
nucleus
1121
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 2 of 2 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0007004
telomere maintenance via telomerase
IMP
GO:0016233
telomere capping
IMP
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0070187
shelterin complex
IPI
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 78 entries
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Interactor
Also a MoonDB EMF protein
ALR2_YEAST
No
ARPC1_YEAST
No
ATPB_YEAST
No
BFR1_YEAST
No
BMH2_YEAST
No
CARP_YEAST
No
CCW12_YEAST
No
CIN8_YEAST
No
COFI_YEAST
No
COG7_YEAST
No
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Publications Associated
Showing 1 to 5 of 5 entries
Search:
PMID
Article Title
9087429
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.
9169871
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
14562106
Global analysis of protein expression in yeast.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 1 of 1 entries
Search:
Domain Name
Domain ID
Source
S55975
S55975
PIR
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