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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: Q06208
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q06208 (Uniprot)
RIF2_YEAST
RIF2
Protein RIF2
yeast
No
Protein Function
Uniprot:
Involved in transcriptional silencing and telomere length regulation. Its role in telomere length regulation results from either a block in elongation or promoting degradation of the telomere ends. Loss of RIF1 function results in derepression of an HMR silencer, whose ARS consensus element has been deleted, and
in the elongation of telomeres. RAP1 may target the binding of RIF1 to silencers and telomeres.
more..
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0044260
cellular macromolecule metabolic process
1063
,
1123
GO:0033036
macromolecule localization
1156
1.18e-20
4.59e-11
GO:0009059
macromolecule biosynthetic process
1121
,
1144
GO:0033036
macromolecule localization
1156
3.71e-18
5.96e-60
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
921
GO:0034645
cellular macromolecule biosynthetic process
921
GO:0044271
cellular nitrogen compound biosynthetic process
921
GO:0090304
nucleic acid metabolic process
962
GO:0006139
nucleobase-containing compound metabolic process
979
GO:0006139
nucleobase-containing compound metabolic process
1019
GO:0034314
Arp2/3 complex-mediated actin nucleation
1059
GO:0090304
nucleic acid metabolic process
1063
GO:0016070
RNA metabolic process
1063
GO:0034645
cellular macromolecule biosynthetic process
1063
GO:0010467
gene expression
1063
GO:0034654
nucleobase-containing compound biosynthetic process
1121
GO:0034645
cellular macromolecule biosynthetic process
1121
GO:0044271
cellular nitrogen compound biosynthetic process
1121
GO:0010467
gene expression
1121
GO:0090304
nucleic acid metabolic process
1123
GO:0016070
RNA metabolic process
1123
GO:0010467
gene expression
1144
GO:0034645
cellular macromolecule biosynthetic process
1144
GO:0034654
nucleobase-containing compound biosynthetic process
1156
GO:0070727
cellular macromolecule localization
1191
GO:0090304
nucleic acid metabolic process
1258
GO:0034645
cellular macromolecule biosynthetic process
1285
GO:0034645
cellular macromolecule biosynthetic process
1361
GO:0090304
nucleic acid metabolic process
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
921
GO:0005634
nucleus
960
GO:0005634
nucleus
982
GO:0043232
intracellular non-membrane-bounded organelle
982
GO:0005634
nucleus
986
GO:0016021
integral component of membrane
1019
GO:0030479
actin cortical patch
1059
GO:0005634
nucleus
1063
GO:0070013
intracellular organelle lumen
1063
GO:0005634
nucleus
1121
GO:0005634
nucleus
1123
GO:0031981
nuclear lumen
1144
GO:0005634
nucleus
1191
GO:0043232
intracellular non-membrane-bounded organelle
1191
GO:0005634
nucleus
1203
GO:0005634
nucleus
1272
GO:0005634
nucleus
1285
GO:0005634
nucleus
1361
GO:0044427
chromosomal part
1361
GO:0031981
nuclear lumen
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0007004
telomere maintenance via telomerase
IMP
GO:0016233
telomere capping
IMP
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000784
nuclear chromosome, telomeric region
IDA
GO:0070187
shelterin complex
IPI
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
MED17_YEAST
No
YP034_YEAST
No
BMH2_YEAST
No
SFT2_YEAST
No
YHB7_YEAST
No
YOX1_YEAST
No
KEL1_YEAST
No
SLK19_YEAST
No
RRP6_YEAST
No
ATPB_YEAST
No
ALR2_YEAST
No
ARPC1_YEAST
No
BFR1_YEAST
No
CARP_YEAST
No
CCW12_YEAST
No
CIN8_YEAST
No
COFI_YEAST
No
COG7_YEAST
No
FAR3_YEAST
No
FDFT_YEAST
No
FEN1_YEAST
No
FKBP4_YEAST
No
FYV6_YEAST
No
GIS3_YEAST
No
GYP2_YEAST
No
HPC2_YEAST
No
HRI1_YEAST
No
HSP30_YEAST
No
IES1_YEAST
No
IF4A_YEAST
No
LYS9_YEAST
No
MGR2_YEAST
No
MKC7_YEAST
No
MRX3_YEAST
No
NKP2_YEAST
No
NOC2_YEAST
No
NOC4_YEAST
No
NRM1_YEAST
No
PCL2_YEAST
No
PEP8_YEAST
No
PHO91_YEAST
No
PML1_YEAST
No
PP2B1_YEAST
No
PPAB_YEAST
No
PPAC_YEAST
No
PRI1_YEAST
No
RAP1_YEAST
No
RCN2_YEAST
No
RDH54_YEAST
No
RIF1_YEAST
No
RNH2A_YEAST
No
RPAC1_YEAST
No
SIP1_YEAST
No
SIR2_YEAST
No
SLD5_YEAST
No
SUR1_YEAST
No
SWI3_YEAST
No
SYM1_YEAST
No
SYWM_YEAST
No
TDA5_YEAST
No
TED1_YEAST
No
TOP1_YEAST
No
UGA4_YEAST
No
WTM1_YEAST
No
YCC3_YEAST
No
YD433_YEAST
No
YG2E_YEAST
No
YIR4_YEAST
No
YJB5_YEAST
No
YM24_YEAST
No
YMD8_YEAST
No
YN00_YEAST
No
YN95_YEAST
No
YN9A_YEAST
No
YNB3_YEAST
No
YO314_YEAST
No
YPS3_YEAST
No
YTP1_YEAST
Yes:
P53584 (MoonDB)
Publications Associated
PMID
Article Title
9087429
A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.
9169871
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
14562106
Global analysis of protein expression in yeast.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
S55975
S55975
PIR