Protein: P63085

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P63085 (Uniprot) MK01_MOUSE Mapk1 Mitogen-activated protein kinase 1 mouse No
Uniprot: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2 (By similarity).Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 1858 GO:0007165 signal transduction 1933 1.18e-123 4.26e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1651 GO:0006464 cellular protein modification process
1662 GO:0048646 anatomical structure formation involved in morphogenesis
1662 GO:0071345 cellular response to cytokine stimulus
1662 GO:0071407 cellular response to organic cyclic compound
1662 GO:0071417 cellular response to organonitrogen compound
1662 GO:1901701 cellular response to oxygen-containing compound
1662 GO:0007010 cytoskeleton organization
1662 GO:0048598 embryonic morphogenesis
1662 GO:0007167 enzyme linked receptor protein signaling pathway
1662 GO:0010638 positive regulation of organelle organization
1662 GO:0045893 positive regulation of transcription, DNA-templated
1662 GO:0009966 regulation of signal transduction
1662 GO:0070848 response to growth factor
1662 GO:0033993 response to lipid
1662 GO:0048863 stem cell differentiation
1858 GO:0044271 cellular nitrogen compound biosynthetic process
1858 GO:0070887 cellular response to chemical stimulus
1858 GO:0035556 intracellular signal transduction
1858 GO:0018105 peptidyl-serine phosphorylation
1858 GO:0051130 positive regulation of cellular component organization
1858 GO:0010628 positive regulation of gene expression
1858 GO:0008104 protein localization
1858 GO:2000112 regulation of cellular macromolecule biosynthetic process
1895 GO:0006915 apoptotic process
1895 GO:0007166 cell surface receptor signaling pathway
1895 GO:0051276 chromosome organization
1895 GO:0032872 regulation of stress-activated MAPK cascade
1895 GO:0006355 regulation of transcription, DNA-templated
1895 GO:0051707 response to other organism
1896 GO:0006915 apoptotic process
1896 GO:0007166 cell surface receptor signaling pathway
1896 GO:0044271 cellular nitrogen compound biosynthetic process
1896 GO:0070887 cellular response to chemical stimulus
1896 GO:0035556 intracellular signal transduction
1896 GO:0006468 protein phosphorylation
1896 GO:2000112 regulation of cellular macromolecule biosynthetic process
1896 GO:0032268 regulation of cellular protein metabolic process
1896 GO:0010468 regulation of gene expression
1912 GO:0071407 cellular response to organic cyclic compound
1912 GO:0071417 cellular response to organonitrogen compound
1912 GO:1901701 cellular response to oxygen-containing compound
1912 GO:0007167 enzyme linked receptor protein signaling pathway
1912 GO:0001701 in utero embryonic development
1912 GO:0060255 regulation of macromolecule metabolic process
1912 GO:0009966 regulation of signal transduction
1912 GO:0048608 reproductive structure development
1933 GO:0007166 cell surface receptor signaling pathway
1933 GO:0010467 gene expression
1933 GO:0015031 protein transport
1933 GO:0009966 regulation of signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1651 GO:0005829 cytosol
1651 GO:0005634 nucleus
1662 GO:0005856 cytoskeleton
1662 GO:0005654 nucleoplasm
1858 GO:0005829 cytosol
1858 GO:0005654 nucleoplasm
1895 GO:0043232 intracellular non-membrane-bounded organelle
1895 GO:0005654 nucleoplasm
1912 GO:0005654 nucleoplasm
1912 GO:0005886 plasma membrane
1933 GO:0012505 endomembrane system
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade IDA
GO:0000187 activation of MAPK activity IEA
GO:0006351 transcription, DNA-templated NAS
GO:0006468 protein phosphorylation IDA
GO:0006915 apoptotic process IEA
GO:0006974 cellular response to DNA damage stimulus IDA
GO:0007049 cell cycle IEA
GO:0007507 heart development IMP
GO:0008284 positive regulation of cell proliferation IEA
GO:0009636 response to toxic substance IEA
GO:0009887 animal organ morphogenesis IDA
GO:0010468 regulation of gene expression IBA
GO:0010628 positive regulation of gene expression ISO
GO:0010800 positive regulation of peptidyl-threonine phosphorylation ISO
GO:0014032 neural crest cell development IGI
GO:0015966 diadenosine tetraphosphate biosynthetic process IEA
GO:0018105 peptidyl-serine phosphorylation IMP
GO:0018107 peptidyl-threonine phosphorylation IDA
GO:0019233 sensory perception of pain IEA
GO:0019858 cytosine metabolic process IDA
GO:0030278 regulation of ossification IGI
GO:0030335 positive regulation of cell migration IEA
GO:0030641 regulation of cellular pH IMP
GO:0030878 thyroid gland development IGI
GO:0031647 regulation of protein stability ISS
GO:0031663 lipopolysaccharide-mediated signaling pathway IDA
GO:0032212 positive regulation of telomere maintenance via telomerase ISO
GO:0032496 response to lipopolysaccharide IDA
GO:0032872 regulation of stress-activated MAPK cascade TAS
GO:0033160 positive regulation of protein import into nucleus, translocation IEA
GO:0033598 mammary gland epithelial cell proliferation IDA
GO:0034198 cellular response to amino acid starvation ISO
GO:0034614 cellular response to reactive oxygen species ISO
GO:0035094 response to nicotine IGI
GO:0038127 ERBB signaling pathway ISO
GO:0042473 outer ear morphogenesis IGI
GO:0043330 response to exogenous dsRNA IDA
GO:0043627 response to estrogen IEA
GO:0045596 negative regulation of cell differentiation IGI
GO:0045727 positive regulation of translation IEA
GO:0045893 positive regulation of transcription, DNA-templated IEA
GO:0048538 thymus development IGI
GO:0050852 T cell receptor signaling pathway IDA
GO:0050853 B cell receptor signaling pathway IDA
GO:0051090 regulation of DNA binding transcription factor activity NAS
GO:0051403 stress-activated MAPK cascade ISO
GO:0051493 regulation of cytoskeleton organization TAS
GO:0051973 positive regulation of telomerase activity ISO
GO:0060020 Bergmann glial cell differentiation IGI
GO:0060291 long-term synaptic potentiation IGI
GO:0060324 face development IMP
GO:0060425 lung morphogenesis IGI
GO:0060440 trachea formation IGI
GO:0060716 labyrinthine layer blood vessel development IMP
GO:0061308 cardiac neural crest cell development involved in heart development IGI
GO:0070371 ERK1 and ERK2 cascade IGI
GO:0070849 response to epidermal growth factor ISO
GO:0071276 cellular response to cadmium ion ISO
GO:0072584 caveolin-mediated endocytosis TAS
GO:0090170 regulation of Golgi inheritance TAS
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
GO:1903351 cellular response to dopamine ISO
GO:1904355 positive regulation of telomere capping ISO
GO:2000641 regulation of early endosome to late endosome transport TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion TAS
GO:0005769 early endosome TAS
GO:0005770 late endosome TAS
GO:0005794 Golgi apparatus TAS
GO:0005815 microtubule organizing center IEA
GO:0005829 cytosol IDA
GO:0005856 cytoskeleton TAS
GO:0005886 plasma membrane ISS
GO:0005901 caveola TAS
GO:0005925 focal adhesion TAS
GO:0030424 axon IEA
GO:0031143 pseudopodium IDA
GO:0032839 dendrite cytoplasm IEA
GO:0043204 perikaryon IEA
GO:0043234 protein complex IEA
GO:0070062 extracellular exosome ISO
GO:0072686 mitotic spindle ISS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005794 Golgi apparatus 1.45e-16 1.34e-03
GO:0005634 nucleus GO:0005886 plasma membrane 1.90e-175 3.75e-40
GO:0005634 nucleus GO:0070062 extracellular exosome 1.57e-02 1.76e-07
GO:0005654 nucleoplasm GO:0005886 plasma membrane 7.70e-80 1.42e-23
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 1.48e-10 2.42e-06
PMID Article Title
1649458 Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation.
1849075 Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).
8444355 Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.
10080542 Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
10753946 Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells.
11090077 Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.
11702783 PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.
12134156 Molecular interpretation of ERK signal duration by immediate early gene products.
15118098 Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15899793 bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.
16141072 The transcriptional landscape of the mammalian genome.
16162500 Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.
16393692 The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.
17242355 Large-scale phosphorylation analysis of mouse liver.
17947660 Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
18034455 Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
19131326 Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.
19565474 The ERK signaling cascade--views from different subcellular compartments.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
21262971 Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.
21779493 The ERK cascade: distinct functions within various subcellular organelles.
22022510 ISG15 modulates development of the erythroid lineage.
No results found.
Domain Name Domain ID Source
Prot_kinase_dom IPR000719 InterPro
MAP_kinase_CS IPR003527 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
MAPK_ERK1/2 IPR008349 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase PF00069 Pfam
ERK1ERK2MAPK PR01770 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
MAPK PS01351 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S16444 S16444 PIR
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM