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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: P60010
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P60010 (Uniprot)
ACT_YEAST
ACT1
Actin
yeast
No
Protein Function
Uniprot:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0097435
supramolecular fiber organization
1242
GO:0006725
cellular aromatic compound metabolic process
962
4.17e-09
4.54e-39
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
962
GO:0006139
nucleobase-containing compound metabolic process
1093
GO:0022607
cellular component assembly
1242
GO:0051666
actin cortical patch localization
1242
GO:0007015
actin filament organization
1242
GO:0034622
cellular macromolecular complex assembly
1242
GO:0006897
endocytosis
1242
GO:1903047
mitotic cell cycle process
1242
GO:0032505
reproduction of a single-celled organism
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
914
GO:0043232
intracellular non-membrane-bounded organelle
1093
GO:0043232
intracellular non-membrane-bounded organelle
1242
GO:0030479
actin cortical patch
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000001
mitochondrion inheritance
TAS
GO:0000011
vacuole inheritance
IMP
GO:0000132
establishment of mitotic spindle orientation
TAS
GO:0000916
actomyosin contractile ring contraction
IMP
GO:0001300
chronological cell aging
IMP
GO:0006281
DNA repair
IDA
GO:0006887
exocytosis
TAS
GO:0006897
endocytosis
IMP
GO:0007119
budding cell isotropic bud growth
TAS
GO:0009306
protein secretion
IMP
GO:0016573
histone acetylation
IDA
GO:0030010
establishment of cell polarity
IGI
GO:0030050
vesicle transport along actin filament
TAS
GO:0030476
ascospore wall assembly
IDA
GO:0031505
fungal-type cell wall organization
TAS
GO:0034599
cellular response to oxidative stress
IGI
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000142
cellular bud neck contractile ring
IDA
GO:0000812
Swr1 complex
IDA
GO:0005884
actin filament
IDA
GO:0030479
actin cortical patch
IDA
GO:0031011
Ino80 complex
IPI
GO:0032432
actin filament bundle
IDA
GO:0035267
NuA4 histone acetyltransferase complex
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
RV167_YEAST
Yes:
P39743 (MoonDB)
FUS1_YEAST
No
BEM1_YEAST
No
BUD6_YEAST
No
BNI1_YEAST
No
RLA4_YEAST
No
AIP1_YEAST
No
CAP_YEAST
No
COFI_YEAST
No
DLD2_YEAST
No
FIMB_YEAST
No
HXKG_YEAST
No
LAS17_YEAST
No
OYE2_YEAST
No
PROF_YEAST
No
VRP1_YEAST
Yes:
P37370 (MoonDB)
Publications Associated
PMID
Article Title
1885608
Unusual metabolism of the yeast actin amino terminus.
1935913
Site-directed mutagenesis of the yeast actin gene: a test for actin function in vivo.
6096014
Lariat structures are in vivo intermediates in yeast pre-mRNA splicing.
6286825
The nucleotide sequences of the actin genes from Saccharomyces carlsbergensis and Saccharomyces cerevisiae are identical except for their introns.
6994099
Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.
7001447
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae.
7003553
Molecular cloning of the actin gene from yeast Saccharomyces cerevisiae.
7670463
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae.
8935650
Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae.
11491363
Partial sequence analysis of the actin gene and its potential for studying the phylogeny of Candida species and their teleomorphs.
12732734
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism.
15126500
YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.
18407956
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
19779198
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
21239490
Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.
22106047
Sites of ubiquitin attachment in Saccharomyces cerevisiae.
22814378
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
ATBY
A03005
PIR
Actin
IPR004000
InterPro
Actin_CS
IPR004001
InterPro
Actin/actin-like_CS
IPR020902
InterPro
JS0702
JS0702
PIR
Actin
PF00022
Pfam
ACTIN
PR00190
PRINTS
ACTINS_1
PS00406
PROSITE
ACTINS_2
PS00432
PROSITE
ACTINS_ACT_LIKE
PS01132
PROSITE
PTHR11937
PTHR11937
PANTHER
ACTIN
SM00268
SMART