Protein: P47992 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P47992 (Uniprot)	XCL1_HUMAN	XCL1	Lymphotactin	human	Yes

Protein Function

Uniprot: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

Dissimilar Functions Manual Curation

Function 1: Lymphotactin chemokine, activates the G-protein coupled receptor XRC1 on taget leukocytes. Canonical chemokine fold. Condition: presence in a monomeric form.

Function 2: Binds glycosaminoglycans, unknown fold. Condition: presence in a dimeric form.

Publications (PMID): 18364395

MoonDB Network Modules

Biological Processes

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
726	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001916	positive regulation of T cell mediated cytotoxicity	IDA
GO:0002548	monocyte chemotaxis	IBA
GO:0002690	positive regulation of leukocyte chemotaxis	ISS
GO:0002725	negative regulation of T cell cytokine production	IDA
GO:0002726	positive regulation of T cell cytokine production	ISS
GO:0002826	negative regulation of T-helper 1 type immune response	IC
GO:0007165	signal transduction	IC
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0007267	cell-cell signaling	IDA
GO:0009615	response to virus	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IBA
GO:0005623	cell	IEA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005623	cell	1.42e-118	1.37e-06
GO:0005615	extracellular space	GO:0005623	cell	3.90e-77	8.83e-06

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
KR103_HUMAN	No
XCR1_HUMAN	No

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Publications Associated

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PMID	Article Title
7602097	Molecular cloning and functional characterization of human lymphotactin.
7615002	Cloning of ATAC, an activation-induced, chemokine-related molecule exclusively expressed in CD8+ T lymphocytes.
7875320	Molecular cloning of a novel C or gamma type chemokine, SCM-1.
8849694	Structure and expression of two highly related genes encoding SCM-1/human lymphotactin.
11601972	Monomeric solution structure of the prototypical 'C' chemokine lymphotactin.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16710414	The DNA sequence and biological annotation of human chromosome 1.

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OMIM Diseases Associated

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Protein Domains Associated

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Domain Name	Domain ID	Source
Chemokine_C	cd00271	CDD
Chemokine_IL8-like_dom	IPR001811	InterPro
Chemokine_XCL1/XCL2	IPR008105	InterPro
ETHUL	S60650	PIR
IL8	PF00048	Pfam
Interleukin_8-like_sf	IPR036048	InterPro
LYMPHOTACTIN	PR01731	PRINTS
PTHR12015:SF101	PTHR12015:SF101	PANTHER
SCY	SM00199	SMART
SSF54117	SSF54117	SUPFAM

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