Protein: P42227

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P42227 (Uniprot) STAT3_MOUSE Stat3 Signal transducer and activator of transcription 3 mouse No
Uniprot: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (PubMed:12594516). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:16825198). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (PubMed:20215569). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (PubMed:23401489). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 1555 GO:0007165 signal transduction 1444 1.18e-123 4.26e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1444 GO:0007166 cell surface receptor signaling pathway
1444 GO:0044267 cellular protein metabolic process
1444 GO:0006796 phosphate-containing compound metabolic process
1444 GO:0048584 positive regulation of response to stimulus
1444 GO:0060255 regulation of macromolecule metabolic process
1465 GO:0006355 regulation of transcription, DNA-templated
1473 GO:0048468 cell development
1473 GO:0007166 cell surface receptor signaling pathway
1473 GO:0070887 cellular response to chemical stimulus
1473 GO:0035556 intracellular signal transduction
1473 GO:0007399 nervous system development
1473 GO:0090304 nucleic acid metabolic process
1473 GO:0031325 positive regulation of cellular metabolic process
1473 GO:0010628 positive regulation of gene expression
1473 GO:0051173 positive regulation of nitrogen compound metabolic process
1473 GO:0006468 protein phosphorylation
1473 GO:0042981 regulation of apoptotic process
1473 GO:0050790 regulation of catalytic activity
1473 GO:0051128 regulation of cellular component organization
1473 GO:2000112 regulation of cellular macromolecule biosynthetic process
1473 GO:0019219 regulation of nucleobase-containing compound metabolic process
1473 GO:0051246 regulation of protein metabolic process
1487 GO:0022607 cellular component assembly
1487 GO:0060255 regulation of macromolecule metabolic process
1487 GO:0007165 signal transduction
1555 GO:0044271 cellular nitrogen compound biosynthetic process
1555 GO:0044267 cellular protein metabolic process
1555 GO:0048584 positive regulation of response to stimulus
1555 GO:2000112 regulation of cellular macromolecule biosynthetic process
1555 GO:0010468 regulation of gene expression
1555 GO:0002682 regulation of immune system process
1555 GO:0009966 regulation of signal transduction
1558 GO:0006355 regulation of transcription, DNA-templated
1558 GO:0006366 transcription from RNA polymerase II promoter
1592 GO:0048468 cell development
1592 GO:0048589 developmental growth
1592 GO:0006928 movement of cell or subcellular component
1592 GO:0030182 neuron differentiation
1592 GO:0090304 nucleic acid metabolic process
1592 GO:0040008 regulation of growth
1632 GO:0022402 cell cycle process
1632 GO:0044271 cellular nitrogen compound biosynthetic process
1632 GO:0050790 regulation of catalytic activity
1632 GO:0031326 regulation of cellular biosynthetic process
1632 GO:0060255 regulation of macromolecule metabolic process
1632 GO:0019219 regulation of nucleobase-containing compound metabolic process
1632 GO:0033043 regulation of organelle organization
1680 GO:0032870 cellular response to hormone stimulus
1680 GO:1901701 cellular response to oxygen-containing compound
1680 GO:0033554 cellular response to stress
1680 GO:0009059 macromolecule biosynthetic process
1680 GO:1901362 organic cyclic compound biosynthetic process
1680 GO:0009893 positive regulation of metabolic process
1680 GO:0050790 regulation of catalytic activity
1680 GO:0010941 regulation of cell death
1680 GO:0031326 regulation of cellular biosynthetic process
1680 GO:0010468 regulation of gene expression
1680 GO:1901698 response to nitrogen compound
1680 GO:0007165 signal transduction
1760 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1810 GO:0048646 anatomical structure formation involved in morphogenesis
1810 GO:0048468 cell development
1810 GO:0071310 cellular response to organic substance
1810 GO:0035556 intracellular signal transduction
1810 GO:0030182 neuron differentiation
1810 GO:0031325 positive regulation of cellular metabolic process
1810 GO:0044093 positive regulation of molecular function
1810 GO:0051247 positive regulation of protein metabolic process
1810 GO:0006468 protein phosphorylation
1810 GO:0042981 regulation of apoptotic process
1810 GO:0050790 regulation of catalytic activity
1810 GO:0010646 regulation of cell communication
1810 GO:0030334 regulation of cell migration
1810 GO:0032268 regulation of cellular protein metabolic process
1810 GO:0042325 regulation of phosphorylation
1810 GO:0023051 regulation of signaling
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1444 GO:0005634 nucleus
1444 GO:0005886 plasma membrane
1465 GO:0031981 nuclear lumen
1473 GO:0005829 cytosol
1473 GO:0043232 intracellular non-membrane-bounded organelle
1473 GO:0005634 nucleus
1473 GO:0005886 plasma membrane
1487 GO:0005829 cytosol
1487 GO:0005615 extracellular space
1487 GO:0005634 nucleus
1487 GO:0005886 plasma membrane
1487 GO:0031982 vesicle
1558 GO:0031981 nuclear lumen
1592 GO:0005829 cytosol
1592 GO:0005654 nucleoplasm
1632 GO:0005813 centrosome
1632 GO:0005829 cytosol
1680 GO:0005829 cytosol
1680 GO:0005634 nucleus
1760 GO:0005654 nucleoplasm
1810 GO:0043232 intracellular non-membrane-bounded organelle
1810 GO:0005634 nucleus
1810 GO:0120025 plasma membrane bounded cell projection
1810 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001659 temperature homeostasis IMP
GO:0001754 eye photoreceptor cell differentiation IMP
GO:0006355 regulation of transcription, DNA-templated NAS
GO:0006366 transcription from RNA polymerase II promoter IDA
GO:0006606 protein import into nucleus ISO
GO:0006953 acute-phase response IEA
GO:0006954 inflammatory response IMP
GO:0007259 JAK-STAT cascade TAS
GO:0007568 aging IEA
GO:0008283 cell proliferation IDA
GO:0008285 negative regulation of cell proliferation IGI
GO:0010628 positive regulation of gene expression IGI
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process IEA
GO:0016310 phosphorylation IDA
GO:0019221 cytokine-mediated signaling pathway NAS
GO:0019827 stem cell population maintenance IMP
GO:0019953 sexual reproduction IMP
GO:0030522 intracellular receptor signaling pathway ISO
GO:0032355 response to estradiol ISO
GO:0032870 cellular response to hormone stimulus ISO
GO:0033210 leptin-mediated signaling pathway IDA
GO:0035278 miRNA mediated inhibition of translation ISO
GO:0040014 regulation of multicellular organism growth IMP
GO:0042493 response to drug IEA
GO:0042593 glucose homeostasis IMP
GO:0042755 eating behavior IMP
GO:0042789 mRNA transcription from RNA polymerase II promoter IDA
GO:0043066 negative regulation of apoptotic process ISO
GO:0044320 cellular response to leptin stimulus ISO
GO:0044321 response to leptin IDA
GO:0045471 response to ethanol IEA
GO:0045648 positive regulation of erythrocyte differentiation ISO
GO:0045747 positive regulation of Notch signaling pathway IMP
GO:0045766 positive regulation of angiogenesis IDA
GO:0045820 negative regulation of glycolytic process IMP
GO:0045893 positive regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0046902 regulation of mitochondrial membrane permeability IEA
GO:0048708 astrocyte differentiation IMP
GO:0051726 regulation of cell cycle IDA
GO:0060019 radial glial cell differentiation IMP
GO:0060259 regulation of feeding behavior IMP
GO:0060396 growth hormone receptor signaling pathway ISO
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IDA
GO:0070102 interleukin-6-mediated signaling pathway ISO
GO:0071345 cellular response to cytokine stimulus ISO
GO:0071407 cellular response to organic cyclic compound ISO
GO:0072540 T-helper 17 cell lineage commitment IMP
GO:0097009 energy homeostasis IMP
GO:1901215 negative regulation of neuron death IEA
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IMP
GO:1904685 positive regulation of metalloendopeptidase activity ISO
GO:1905564 positive regulation of vascular endothelial cell proliferation IDA
GO:2000637 positive regulation of gene silencing by miRNA ISO
GO:2000737 negative regulation of stem cell differentiation IMP
GO:2001171 positive regulation of ATP biosynthetic process IEA
GO:2001223 negative regulation of neuron migration IGI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin ISO
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005743 mitochondrial inner membrane IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IDA
GO:0090575 RNA polymerase II transcription factor complex ISO
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005886 plasma membrane 4.71e-20 2.17e-23
GO:0005634 nucleus GO:0005886 plasma membrane 1.90e-175 3.75e-40
GO:0005654 nucleoplasm GO:0005886 plasma membrane 7.70e-80 1.42e-23
GO:0005886 plasma membrane GO:0090575 RNA polymerase II transcription factor complex 6.58e-07 5.97e-18
PMID Article Title
7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
7523373 Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.
7543024 Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation.
7568080 Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3.
8140422 Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
9108058 Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality.
9388184 Specific inhibition of Stat3 signal transduction by PIAS3.
9671298 Three-dimensional structure of the Stat3beta homodimer bound to DNA.
10878010 FER kinase activation of Stat3 is determined by the N-terminal sequence.
10954736 A Stat3-interacting protein (StIP1) regulates cytokine signal transduction.
11161808 Structure of the mouse Stat 3/5 locus: evolution from Drosophila to zebrafish to mouse.
11294897 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.
11553624 MSK1 and JNKs mediate phosphorylation of STAT3 in UVA-irradiated mouse epidermal JB6 cells.
12594516 STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
15004007 Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15919823 STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.
16401721 Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin.
16825198 Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2).
18034455 Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
18234692 BART is essential for nuclear retention of STAT3.
19468303 Lineage-specific biology revealed by a finished genome assembly of the mouse.
20215569 Glucose intolerance and impaired insulin secretion in pancreas-specific signal transducer and activator of transcription-3 knockout mice are associated with microvascular alterations in the pancreas.
20595392 Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells.
21135090 Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.
21183079 A tissue-specific atlas of mouse protein phosphorylation and expression.
23084476 Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.
23401489 Innate Stat3-mediated induction of the antimicrobial protein Reg3gamma is required for host defense against MRSA pneumonia.
23972987 Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
No results found.
Domain Name Domain ID Source
I49508 I49508 PIR
SH2 IPR000980 InterPro
STAT IPR001217 InterPro
p53-like_TF_DNA-bd IPR008967 InterPro
STAT_TF_DNA-bd_N IPR012345 InterPro
STAT_TF_prot_interaction IPR013799 InterPro
STAT_TF_alpha IPR013800 InterPro
STAT_TF_DNA-bd IPR013801 InterPro
STAT_TF_coiled-coil IPR015988 InterPro
STAT3_SH2 IPR035855 InterPro
STAT_N_sf IPR036535 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
STAT_alpha PF01017 Pfam
STAT_bind PF02864 Pfam
STAT_int PF02865 Pfam
SH2 PS50001 PROSITE
PTHR11801 PTHR11801 PANTHER
STAT_int SM00964 SMART
SSF47655 SSF47655 SUPFAM
SSF48092 SSF48092 SUPFAM
SSF49417 SSF49417 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_STAT3 cd10374 CDD