Protein: P32856

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P32856 (Uniprot) STX2_HUMAN STX2 Syntaxin-2 human Yes
Uniprot: Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
Dissimilar Functions Manual Curation

Function 1: Epithelial morphogen signalling, binds alpha-intergrins. Condition: extracellular localisation.

Function 2: Vesicle fusion. Condition: intracellular localisation.

Publications (PMID): 18354082, 17535848

Biological Processes
No results found.
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
85 GO:0016021 integral component of membrane
389 GO:0012505 endomembrane system
389 GO:0016021 integral component of membrane
633 GO:0005829 cytosol
633 GO:0031982 vesicle
858 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006886 intracellular protein transport IBA
GO:0007165 signal transduction TAS
GO:0007340 acrosome reaction ISS
GO:0007398 ectoderm development TAS
GO:0009887 animal organ morphogenesis TAS
GO:0030154 cell differentiation IEA
GO:0030193 regulation of blood coagulation IMP
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane IBA
GO:0033194 response to hydroperoxide IDA
GO:0048278 vesicle docking IBA
GO:0051259 protein oligomerization IDA
GO:1903575 cornified envelope assembly IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005886 plasma membrane IDA
GO:0008021 synaptic vesicle IBA
GO:0016021 integral component of membrane IBA
GO:0016323 basolateral plasma membrane IDA
GO:0030027 lamellipodium IDA
GO:0031201 SNARE complex IBA
GO:0043231 intracellular membrane-bounded organelle TAS
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005615 extracellular space GO:0043231 intracellular membrane-bounded organelle 5.04e-30 2.07e-03
GO:0005886 plasma membrane GO:0043231 intracellular membrane-bounded organelle 0.00e+00 3.79e-47
GO:0016021 integral component of membrane GO:0043231 intracellular membrane-bounded organelle 3.85e-142 2.23e-72
PMID Article Title
8466509 Molecular cloning of human epimorphin: identification of isoforms and their unique properties.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075 The finished DNA sequence of human chromosome 12.
No results found.
Domain Name Domain ID Source
T_SNARE_dom IPR000727 InterPro
Syntaxin_N IPR006011 InterPro
Syntaxin/epimorphin_CS IPR006012 InterPro
SNARE IPR010989 InterPro
STX2 IPR028671 InterPro
JN0466 JN0466 PIR
Syntaxin PF00804 Pfam
SNARE PF05739 Pfam
SYNTAXIN PS00914 PROSITE
T_SNARE PS50192 PROSITE
PTHR19957:SF36 PTHR19957:SF36 PANTHER
t_SNARE SM00397 SMART
SynN SM00503 SMART
SSF47661 SSF47661 SUPFAM