Protein: P27540 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P27540 (Uniprot)	ARNT_HUMAN	ARNT	Aryl hydrocarbon receptor nuclear translocator	human	No

Protein Function

Uniprot: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HI more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	152	GO:0007165	signal transduction	169	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
152	GO:0006139	nucleobase-containing compound metabolic process
169	GO:0030522	intracellular receptor signaling pathway
169	GO:0045892	negative regulation of transcription, DNA-templated
169	GO:0045944	positive regulation of transcription from RNA polymerase II promoter
169	GO:0043401	steroid hormone mediated signaling pathway
471	GO:0034645	cellular macromolecule biosynthetic process
471	GO:0044271	cellular nitrogen compound biosynthetic process
471	GO:0006464	cellular protein modification process
471	GO:0031324	negative regulation of cellular metabolic process
471	GO:0010605	negative regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
152	GO:0005829	cytosol
152	GO:0005634	nucleus
169	GO:0005654	nucleoplasm
471	GO:0005654	nucleoplasm
632	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001666	response to hypoxia	IDA
GO:0001892	embryonic placenta development	IEA
GO:0001938	positive regulation of endothelial cell proliferation	IC
GO:0006351	transcription, DNA-templated	TAS
GO:0006805	xenobiotic metabolic process	TAS
GO:0010575	positive regulation of vascular endothelial growth factor production	IDA
GO:0030154	cell differentiation	IEA
GO:0030522	intracellular receptor signaling pathway	IEA
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	IC
GO:0033235	positive regulation of protein sumoylation	IEA

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IEA
GO:0016604	nuclear body	IDA
GO:0090575	RNA polymerase II transcription factor complex	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ADHX_HUMAN	No
AHR_HUMAN	No
AHRR_HUMAN	No
ARL14_HUMAN	No
BACD2_HUMAN	No
DBLOH_HUMAN	Yes: Q9NR28 (MoonDB)
EPAS1_HUMAN	No
GEMI_HUMAN	No
HEY1_HUMAN	No
HEY2_HUMAN	No

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Publications Associated

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PMID	Article Title
1317062	Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
1852076	Cloning of a factor required for activity of the Ah (dioxin) receptor.
7539918	Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
8621524	Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions.
10395741	Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
11230166	Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
16710414	The DNA sequence and biological annotation of human chromosome 1.
18669648	A quantitative atlas of mitotic phosphorylation.
20699359	Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
BHLH	PS50888	PROSITE
bHLH_dom	IPR011598	InterPro
HLH	PF00010	Pfam
HLH	SM00353	SMART
HLH	cd00083	CDD
HLH_DNA-bd_sf	IPR036638	InterPro
I59550	I59550	PIR
NCTRNSLOCATR	PR00785	PRINTS
Nuc_translocat	IPR001067	InterPro
PAC	IPR001610	InterPro

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