Protein: P25233

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P25233 (Uniprot) NECD_MOUSE Ndn Necdin mouse No
Uniprot: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009059 macromolecule biosynthetic process 1675, 1884 GO:0022610 biological adhesion 1449 3.06e-14 9.72e-30
GO:0009059 macromolecule biosynthetic process 1675, 1884 GO:0007165 signal transduction 1818 2.28e-48 1.95e-17
GO:0009059 macromolecule biosynthetic process 1675, 1884 GO:0065008 regulation of biological quality 1982 6.00e-08 2.17e-02
GO:0044260 cellular macromolecule metabolic process 1686 GO:0022610 biological adhesion 1449 4.51e-12 5.19e-04
GO:0006355 regulation of transcription, DNA-templated 1714 GO:0022610 biological adhesion 1449 4.83e-02 3.44e-15
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1449 GO:0007155 cell adhesion
1449 GO:0048468 cell development
1449 GO:0016477 cell migration
1449 GO:0007417 central nervous system development
1449 GO:0048699 generation of neurons
1449 GO:0042063 gliogenesis
1449 GO:0060255 regulation of macromolecule metabolic process
1452 GO:0010467 gene expression
1489 GO:0060255 regulation of macromolecule metabolic process
1586 GO:0006355 regulation of transcription, DNA-templated
1586 GO:0006366 transcription from RNA polymerase II promoter
1592 GO:0048468 cell development
1592 GO:0048589 developmental growth
1592 GO:0006928 movement of cell or subcellular component
1592 GO:0030182 neuron differentiation
1592 GO:0090304 nucleic acid metabolic process
1592 GO:0040008 regulation of growth
1635 GO:0051253 negative regulation of RNA metabolic process
1635 GO:0010629 negative regulation of gene expression
1635 GO:0031328 positive regulation of cellular biosynthetic process
1635 GO:0010628 positive regulation of gene expression
1635 GO:0010557 positive regulation of macromolecule biosynthetic process
1635 GO:0051173 positive regulation of nitrogen compound metabolic process
1635 GO:0006357 regulation of transcription from RNA polymerase II promoter
1635 GO:0007165 signal transduction
1637 GO:0031325 positive regulation of cellular metabolic process
1637 GO:0010604 positive regulation of macromolecule metabolic process
1637 GO:0051173 positive regulation of nitrogen compound metabolic process
1637 GO:0006357 regulation of transcription from RNA polymerase II promoter
1650 GO:0016477 cell migration
1650 GO:0030182 neuron differentiation
1650 GO:0006355 regulation of transcription, DNA-templated
1675 GO:0034645 cellular macromolecule biosynthetic process
1675 GO:0044271 cellular nitrogen compound biosynthetic process
1675 GO:0010467 gene expression
1682 GO:0016049 cell growth
1682 GO:0040008 regulation of growth
1685 GO:0006928 movement of cell or subcellular component
1685 GO:0120036 plasma membrane bounded cell projection organization
1686 GO:0016070 RNA metabolic process
1695 GO:0048468 cell development
1695 GO:0007166 cell surface receptor signaling pathway
1695 GO:0007417 central nervous system development
1695 GO:0042063 gliogenesis
1714 GO:0006357 regulation of transcription from RNA polymerase II promoter
1791 GO:0048468 cell development
1791 GO:0007417 central nervous system development
1791 GO:0048699 generation of neurons
1791 GO:0042592 homeostatic process
1791 GO:0006928 movement of cell or subcellular component
1791 GO:0048011 neurotrophin TRK receptor signaling pathway
1791 GO:0120036 plasma membrane bounded cell projection organization
1791 GO:0060255 regulation of macromolecule metabolic process
1794 GO:0071310 cellular response to organic substance
1794 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1818 GO:0007166 cell surface receptor signaling pathway
1818 GO:0006928 movement of cell or subcellular component
1818 GO:0008285 negative regulation of cell proliferation
1818 GO:0007399 nervous system development
1818 GO:0120036 plasma membrane bounded cell projection organization
1818 GO:0031325 positive regulation of cellular metabolic process
1818 GO:0010604 positive regulation of macromolecule metabolic process
1818 GO:0051173 positive regulation of nitrogen compound metabolic process
1818 GO:0006355 regulation of transcription, DNA-templated
1828 GO:0071363 cellular response to growth factor stimulus
1828 GO:0007167 enzyme linked receptor protein signaling pathway
1838 GO:0031175 neuron projection development
1838 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1838 GO:0007165 signal transduction
1846 GO:0006928 movement of cell or subcellular component
1884 GO:0008283 cell proliferation
1884 GO:0034645 cellular macromolecule biosynthetic process
1884 GO:0090304 nucleic acid metabolic process
1891 GO:0006355 regulation of transcription, DNA-templated
1914 GO:0048589 developmental growth
1914 GO:0007167 enzyme linked receptor protein signaling pathway
1914 GO:0120036 plasma membrane bounded cell projection organization
1914 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1914 GO:0042127 regulation of cell proliferation
1919 GO:0007409 axonogenesis
1919 GO:0007417 central nervous system development
1919 GO:0006928 movement of cell or subcellular component
1919 GO:0050877 nervous system process
1920 GO:0006357 regulation of transcription from RNA polymerase II promoter
1922 GO:0007409 axonogenesis
1922 GO:0007417 central nervous system development
1922 GO:0048588 developmental cell growth
1922 GO:0060560 developmental growth involved in morphogenesis
1941 GO:0071310 cellular response to organic substance
1941 GO:0090304 nucleic acid metabolic process
1941 GO:0060255 regulation of macromolecule metabolic process
1941 GO:0019219 regulation of nucleobase-containing compound metabolic process
1946 GO:0007417 central nervous system development
1982 GO:0042592 homeostatic process
2006 GO:0010467 gene expression
2006 GO:0006139 nucleobase-containing compound metabolic process
2031 GO:0016070 RNA metabolic process
2031 GO:0034645 cellular macromolecule biosynthetic process
2031 GO:0044271 cellular nitrogen compound biosynthetic process
2031 GO:0010467 gene expression
2033 GO:0031325 positive regulation of cellular metabolic process
2033 GO:0010604 positive regulation of macromolecule metabolic process
2033 GO:0051173 positive regulation of nitrogen compound metabolic process
2076 GO:0007600 sensory perception
2095 GO:0045893 positive regulation of transcription, DNA-templated
2095 GO:0006357 regulation of transcription from RNA polymerase II promoter
2106 GO:0000902 cell morphogenesis
2106 GO:0045893 positive regulation of transcription, DNA-templated
2123 GO:0048666 neuron development
2123 GO:0090304 nucleic acid metabolic process
2124 GO:0016070 RNA metabolic process
2124 GO:0010467 gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1449 GO:0031012 extracellular matrix
1449 GO:0005615 extracellular space
1452 GO:0005829 cytosol
1452 GO:0043232 intracellular non-membrane-bounded organelle
1452 GO:0005634 nucleus
1489 GO:0005634 nucleus
1586 GO:0005634 nucleus
1589 GO:0005794 Golgi apparatus
1589 GO:0031090 organelle membrane
1589 GO:0031984 organelle subcompartment
1592 GO:0005829 cytosol
1592 GO:0005654 nucleoplasm
1635 GO:0005829 cytosol
1635 GO:0005654 nucleoplasm
1637 GO:0005634 nucleus
1650 GO:0005829 cytosol
1650 GO:0043232 intracellular non-membrane-bounded organelle
1650 GO:0031981 nuclear lumen
1675 GO:0005829 cytosol
1675 GO:0005634 nucleus
1685 GO:0042995 cell projection
1685 GO:0005813 centrosome
1685 GO:0005829 cytosol
1685 GO:0044428 nuclear part
1686 GO:0043232 intracellular non-membrane-bounded organelle
1686 GO:0031981 nuclear lumen
1695 GO:0042995 cell projection
1714 GO:0043232 intracellular non-membrane-bounded organelle
1714 GO:0005654 nucleoplasm
1791 GO:0042995 cell projection
1791 GO:0005813 centrosome
1791 GO:0005829 cytosol
1791 GO:0031981 nuclear lumen
1794 GO:0042995 cell projection
1794 GO:0005654 nucleoplasm
1814 GO:0044430 cytoskeletal part
1815 GO:0044430 cytoskeletal part
1818 GO:0042995 cell projection
1818 GO:0005813 centrosome
1838 GO:0005634 nucleus
1846 GO:0042995 cell projection
1846 GO:0044430 cytoskeletal part
1846 GO:0015630 microtubule cytoskeleton
1884 GO:0043232 intracellular non-membrane-bounded organelle
1884 GO:0031981 nuclear lumen
1891 GO:0005634 nucleus
1907 GO:0044430 cytoskeletal part
1914 GO:0005829 cytosol
1914 GO:0005654 nucleoplasm
1919 GO:0042995 cell projection
1919 GO:0044430 cytoskeletal part
1919 GO:0005829 cytosol
1920 GO:0005829 cytosol
1920 GO:0043232 intracellular non-membrane-bounded organelle
1920 GO:0031981 nuclear lumen
1922 GO:0042995 cell projection
1922 GO:0005813 centrosome
1922 GO:0031981 nuclear lumen
1941 GO:0005634 nucleus
1952 GO:0005829 cytosol
1952 GO:0043232 intracellular non-membrane-bounded organelle
1952 GO:0005654 nucleoplasm
1966 GO:0005829 cytosol
1966 GO:0043232 intracellular non-membrane-bounded organelle
1966 GO:0005654 nucleoplasm
2003 GO:0043232 intracellular non-membrane-bounded organelle
2003 GO:0005634 nucleus
2006 GO:0005829 cytosol
2031 GO:0005829 cytosol
2031 GO:0043232 intracellular non-membrane-bounded organelle
2031 GO:0005634 nucleus
2031 GO:0031982 vesicle
2033 GO:0005829 cytosol
2033 GO:0005634 nucleus
2048 GO:0005634 nucleus
2076 GO:0005634 nucleus
2087 GO:0042995 cell projection
2095 GO:0044430 cytoskeletal part
2095 GO:0015630 microtubule cytoskeleton
2095 GO:0005654 nucleoplasm
2106 GO:0043232 intracellular non-membrane-bounded organelle
2106 GO:0005654 nucleoplasm
2123 GO:0043232 intracellular non-membrane-bounded organelle
2123 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001764 neuron migration IMP
GO:0003016 respiratory system process IMP
GO:0006355 regulation of transcription, DNA-templated IGI
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0007409 axonogenesis IMP
GO:0007413 axonal fasciculation IMP
GO:0007417 central nervous system development IMP
GO:0007585 respiratory gaseous exchange IMP
GO:0008285 negative regulation of cell proliferation IEA
GO:0008347 glial cell migration IMP
GO:0009791 post-embryonic development IMP
GO:0019233 sensory perception of pain IMP
GO:0040008 regulation of growth IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA
GO:0048011 neurotrophin TRK receptor signaling pathway IMP
GO:0048666 neuron development IMP
GO:0048675 axon extension IMP
GO:0048871 multicellular organismal homeostasis IMP
GO:0071514 genetic imprinting IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm ISO
GO:0005737 cytoplasm IDA
GO:0005813 centrosome IDA
GO:0005829 cytosol IDA
GO:0016363 nuclear matrix IEA
GO:0042995 cell projection IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0042995 cell projection 9.94e-05 1.27e-06
PMID Article Title
2069569 A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells.
8557705 Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter.
9422723 Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
10347180 Physical and functional interactions of neuronal growth suppressor necdin with p53.
10965153 Cellular and subcellular localization of necdin in fetal and adult mouse brain.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072 The transcriptional landscape of the mammalian genome.
No results found.
Domain Name Domain ID Source
MHD_dom IPR002190 InterPro
Necdin IPR030086 InterPro
MAGE IPR037445 InterPro
JN0148 JN0148 PIR
MAGE PF01454 Pfam
MAGE PS50838 PROSITE
PTHR11736 PTHR11736 PANTHER
PTHR11736:SF10 PTHR11736:SF10 PANTHER
MAGE SM01373 SMART