Protein: P25233 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P25233 (Uniprot)	NECD_MOUSE	Ndn	Necdin	mouse	No

Protein Function

Uniprot: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006355	regulation of transcription, DNA-templated	1714	GO:0022610	biological adhesion	1449	4.83e-02	3.44e-15
GO:0009059	macromolecule biosynthetic process	1675, 1884	GO:0022610	biological adhesion	1449	3.06e-14	9.72e-30
GO:0009059	macromolecule biosynthetic process	1675, 1884	GO:0007165	signal transduction	1818	2.28e-48	1.95e-17
GO:0009059	macromolecule biosynthetic process	1675, 1884	GO:0065008	regulation of biological quality	1982	6.00e-08	2.17e-02
GO:0044260	cellular macromolecule metabolic process	1686	GO:0022610	biological adhesion	1449	4.51e-12	5.19e-04

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
1449	GO:0007155	cell adhesion
1449	GO:0048468	cell development
1449	GO:0016477	cell migration
1449	GO:0007417	central nervous system development
1449	GO:0048699	generation of neurons
1449	GO:0042063	gliogenesis
1449	GO:0060255	regulation of macromolecule metabolic process
1452	GO:0010467	gene expression
1489	GO:0060255	regulation of macromolecule metabolic process
1586	GO:0006355	regulation of transcription, DNA-templated

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
1449	GO:0031012	extracellular matrix
1449	GO:0005615	extracellular space
1452	GO:0005829	cytosol
1452	GO:0043232	intracellular non-membrane-bounded organelle
1452	GO:0005634	nucleus
1489	GO:0005634	nucleus
1586	GO:0005634	nucleus
1589	GO:0005794	Golgi apparatus
1589	GO:0031090	organelle membrane
1589	GO:0031984	organelle subcompartment

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001764	neuron migration	IMP
GO:0003016	respiratory system process	IMP
GO:0006355	regulation of transcription, DNA-templated	IGI
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0007409	axonogenesis	IMP
GO:0007413	axonal fasciculation	IMP
GO:0007417	central nervous system development	IMP
GO:0007585	respiratory gaseous exchange	IMP
GO:0008285	negative regulation of cell proliferation	IEA
GO:0008347	glial cell migration	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	ISO
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	IDA
GO:0005829	cytosol	IDA
GO:0016363	nuclear matrix	IEA
GO:0042995	cell projection	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0042995	cell projection	9.94e-05	1.27e-06

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANGL2_MOUSE	No
CABP1_MOUSE	No
CADH2_MOUSE	No
CADH4_MOUSE	No
CADH5_MOUSE	No
CCAR1_MOUSE	No
CCM2_MOUSE	No
CH037_MOUSE	No
CHM4B_MOUSE	No
CHMP5_MOUSE	No

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Publications Associated

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PMID	Article Title
2069569	A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells.
8557705	Structure and expression of the mouse necdin gene. Identification of a postmitotic neuron-restrictive core promoter.
9422723	Necdin, a postmitotic neuron-specific growth suppressor, interacts with viral transforming proteins and cellular transcription factor E2F1.
10347180	Physical and functional interactions of neuronal growth suppressor necdin with p53.
10965153	Cellular and subcellular localization of necdin in fetal and adult mouse brain.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16141072	The transcriptional landscape of the mammalian genome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

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Domain Name	Domain ID	Source
JN0148	JN0148	PIR
MAGE	IPR037445	InterPro
MAGE	PF01454	Pfam
MAGE	PS50838	PROSITE
MAGE	SM01373	SMART
MHD_dom	IPR002190	InterPro
Necdin	IPR030086	InterPro
PTHR11736	PTHR11736	PANTHER
PTHR11736:SF10	PTHR11736:SF10	PANTHER

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