Protein: P23219 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P23219 (Uniprot)	PGH1_HUMAN	PTGS1	Prostaglandin G/H synthase 1	human	Yes

Protein Function

Uniprot: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which p more..

Dissimilar Functions Manual Curation

Function 1: Heme-dependant peroxidase.

Function 2: Cyclooxygenase. Both isozymes known to have the dual function. Condition: for the cyclooxygenase activities of PGHS-1 and PGHS-2 to function, the heme group at the peroxidase site must undergo a lipid peroxide-dependent oxidation.

Publications (PMID): 8121489, 11413152

MoonDB Network Modules

Biological Processes

Showing 1 to 4 of 4 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
877	GO:0070887	cellular response to chemical stimulus
877	GO:0019371	cyclooxygenase pathway
877	GO:0006954	inflammatory response
877	GO:0055114	oxidation-reduction process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
877	GO:0005789	endoplasmic reticulum membrane
877	GO:0005615	extracellular space
877	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001516	prostaglandin biosynthetic process	ISS
GO:0006629	lipid metabolic process	NAS
GO:0006805	xenobiotic metabolic process	TAS
GO:0006954	inflammatory response	IEA
GO:0006979	response to oxidative stress	IEA
GO:0008217	regulation of blood pressure	ISS
GO:0019371	cyclooxygenase pathway	TAS
GO:0042127	regulation of cell proliferation	IEA
GO:0055114	oxidation-reduction process	IEA
GO:0098869	cellular oxidant detoxification	IEA

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Cellular Components

Showing 1 to 8 of 8 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0001750	photoreceptor outer segment	IEA
GO:0005634	nucleus	ISS
GO:0005737	cytoplasm	IDA
GO:0005789	endoplasmic reticulum membrane	TAS
GO:0005794	Golgi apparatus	IDA
GO:0031090	organelle membrane	IEA
GO:0043231	intracellular membrane-bounded organelle	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 4 of 4 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005789	endoplasmic reticulum membrane	1.61e-25	3.10e-56
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0031090	organelle membrane	1.06e-37	1.89e-52
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
PTGIS_HUMAN	No

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Publications Associated

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PMID	Article Title
1587858	Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha.
1734857	Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).
1907252	Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment.
2512924	Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme.
10966456	Cyclooxygenases: structural, cellular, and molecular biology.
12192304	Characterization of the human prostaglandin H synthase 1 gene (PTGS1): exclusion by genetic linkage analysis as a second modifier gene in familial thrombosis.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053	DNA sequence and analysis of human chromosome 9.
15308583	Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
An_peroxidase	PF03098	Pfam
ANPEROXIDASE	PR00457	PRINTS
COX-1	IPR029580	InterPro
EGF	PF00008	Pfam
EGF-like_dom	IPR000742	InterPro
EGF_3	PS50026	PROSITE
Haem_peroxidase	IPR010255	InterPro
Haem_peroxidase_animal	IPR019791	InterPro
Haem_peroxidase_sf	IPR037120	InterPro
HsPGHS01	3320	PeroxiBase

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