Protein: P19414 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P19414 (Uniprot)	ACON_YEAST	ACO1	Aconitate hydratase, mitochondrial	yeast	Yes

Protein Function

Uniprot: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Plays also an essential role in mtD more..

Dissimilar Functions Manual Curation

Function 1: Aconitase.

Function 2: Maintenance of mitochondrial DNA (independent of its catalytic activity).

Publications (PMID): 18322039, 15692048

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

No results found.

Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000002	mitochondrial genome maintenance	IMP
GO:0006099	tricarboxylic acid cycle	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005758	mitochondrial intermembrane space	TAS
GO:0005759	mitochondrial matrix	IDA
GO:0005829	cytosol	TAS
GO:0042645	mitochondrial nucleoid	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CHS1_YEAST	No

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Publications Associated

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PMID	Article Title
1972545	Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.
9169871	The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
10224250	Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.
14562106	Global analysis of protein expression in yeast.
15692048	Aconitase couples metabolic regulation to mitochondrial DNA maintenance.
15975908	Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.
17330950	Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
17698960	Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
17761666	Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.
18359281	Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Acnase/IPM_dHydase_lsu_aba_1/3	IPR015931	InterPro
Acoase/IPM_deHydtase_lsu_aba	IPR001030	InterPro
Aconitase	PF00330	Pfam
ACONITASE	PR00415	PRINTS
Aconitase/3IPM_dehydase_swvl	IPR015928	InterPro
ACONITASE_1	PS00450	PROSITE
ACONITASE_2	PS01244	PROSITE
Aconitase_4Fe-4S_BS	IPR018136	InterPro
Aconitase_4Fe-4S_dom	IPR036008	InterPro
Aconitase_C	PF00694	Pfam

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