Protein: P19414

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P19414 (Uniprot) ACON_YEAST ACO1 Aconitate hydratase, mitochondrial yeast Yes
Uniprot: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Can also provide minor contributions to the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. Plays also an essential role in mtDNA maintenance. May directly protect mtDNA from accumulation of point mutations and ssDNA breaks as a component of mitochondrial nucleoids, or by preventing accumulation of iron citrate thereby alleviating its detrimental effects in mitochondria. more..
Dissimilar Functions Manual Curation

Function 1: Aconitase.

Function 2: Maintenance of mitochondrial DNA (independent of its catalytic activity).

Publications (PMID): 18322039, 15692048

GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000002 mitochondrial genome maintenance IMP
GO:0006099 tricarboxylic acid cycle IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005758 mitochondrial intermembrane space TAS
GO:0005759 mitochondrial matrix IDA
GO:0005829 cytosol TAS
GO:0042645 mitochondrial nucleoid IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
CHS1_YEAST No
PMID Article Title
1972545 Molecular cloning of the yeast mitochondrial aconitase gene (ACO1) and evidence of a synergistic regulation of expression by glucose plus glutamate.
9169871 The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
10224250 Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes.
14562106 Global analysis of protein expression in yeast.
15692048 Aconitase couples metabolic regulation to mitochondrial DNA maintenance.
15975908 Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing.
17330950 Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
17698960 Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA.
17761666 Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase.
18359281 Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase.
18577574 The mitochondrial targeting sequence tilts the balance between mitochondrial and cytosolic dual localization.
19779198 Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
21440554 The aconitase C-terminal domain is an independent dual targeting element.
23106124 The fungal alpha-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.
24066190 Mitochondrial DNA instability in cells lacking aconitase correlates with iron citrate toxicity.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
No results found.
Domain Name Domain ID Source
AconitaseA/IPMdHydase_ssu_swvl IPR000573 InterPro
Acoase/IPM_deHydtase_lsu_aba IPR001030 InterPro
Aconitase_mito-like IPR006248 InterPro
Aconitase/3IPM_dehydase_swvl IPR015928 InterPro
Acnase/IPM_dHydase_lsu_aba_1/3 IPR015931 InterPro
Aconitase_dom2 IPR015932 InterPro
Aconitase_4Fe-4S_BS IPR018136 InterPro
Aconitase_4Fe-4S_dom IPR036008 InterPro
Aconitase PF00330 Pfam
Aconitase_C PF00694 Pfam
ACONITASE PR00415 PRINTS
ACONITASE_1 PS00450 PROSITE
ACONITASE_2 PS01244 PROSITE
S50387 S50387 PIR
SSF53732 SSF53732 SUPFAM
aconitase_mito TIGR01340 TIGRFAMs