Protein: P06744 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P06744 (Uniprot)	G6PI_HUMAN	GPI	Glucose-6-phosphate isomerase	human	Yes

Protein Function

Uniprot: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

Dissimilar Functions Manual Curation

Function 1: Glycolytic enzyme. Phosphoglucose isomerase (PGI). Condition: cytosol localisation.

Function 2: Tumor-secreted cytokine. Neuroleukin, autocrine mobility factor, nerve growth factor, differentiation and maturation mediator. Condition: extracellular localisation.

Publications (PMID): 8639816, 15877277, 3020690, 8674049, 12714060

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
190	GO:0005829	cytosol
190	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001525	angiogenesis	IEA
GO:0001701	in utero embryonic development	IEA
GO:0001707	mesoderm formation	IEA
GO:0005975	carbohydrate metabolic process	NAS
GO:0006094	gluconeogenesis	TAS
GO:0006959	humoral immune response	TAS
GO:0007599	hemostasis	TAS
GO:0007611	learning or memory	IEA
GO:0010469	regulation of receptor activity	IEA
GO:0019242	methylglyoxal biosynthetic process	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005654	nucleoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IDA
GO:0016020	membrane	IDA
GO:0034774	secretory granule lumen	TAS
GO:0043005	neuron projection	IEA
GO:0043209	myelin sheath	IEA
GO:0060170	ciliary membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
SPICE_HUMAN	Yes: Q8N0Z3 (MoonDB)

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Publications Associated

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PMID	Article Title
2387591	Characterization of the 5' end of the gene for human glucose phosphate isomerase (GPI).
3352745	Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences.
7989588	The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia.
8499925	DNA sequence abnormalities in human glucose 6-phosphate isomerase deficiency.
8822952	Study of the molecular defects in glucose phosphate isomerase-deficient patients affected by chronic hemolytic anemia.
8822954	Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia.
9446754	Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).
9856489	Molecular basis of neurological dysfunction coupled with haemolytic anaemia in human glucose-6-phosphate isomerase (GPI) deficiency.
10727272	Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination.
11004567	Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.

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OMIM Diseases Associated

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OMIM ID	Disease Name
613470	Hemolytic anemia, non-spherocytic, due to glucose phosphate isomerase deficiency

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Protein Domains Associated

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Domain Name	Domain ID	Source
A35333	A35333	PIR
G6P_Isomerase	IPR001672	InterPro
G6P_isomerase	MF_00473	HAMAP
G6P_Isomerase_C	IPR023096	InterPro
G6PISOMERASE	PR00662	PRINTS
P_GLUCOSE_ISOMERASE_1	PS00765	PROSITE
P_GLUCOSE_ISOMERASE_2	PS00174	PROSITE
P_GLUCOSE_ISOMERASE_3	PS51463	PROSITE
PGI	PF00342	Pfam
Phosphoglucose_isomerase_CS	IPR018189	InterPro

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