Protein: O88470

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O88470 (Uniprot) FOXL2_MOUSE Foxl2 Forkhead box protein L2 mouse No
Uniprot: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 1554 GO:0007165 signal transduction 1623 1.18e-123 4.26e-23
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1462 GO:0044267 cellular protein metabolic process
1462 GO:0031325 positive regulation of cellular metabolic process
1462 GO:0010604 positive regulation of macromolecule metabolic process
1462 GO:0051173 positive regulation of nitrogen compound metabolic process
1462 GO:0006357 regulation of transcription from RNA polymerase II promoter
1526 GO:0006355 regulation of transcription, DNA-templated
1540 GO:0044267 cellular protein metabolic process
1540 GO:0010467 gene expression
1540 GO:0006796 phosphate-containing compound metabolic process
1540 GO:0060255 regulation of macromolecule metabolic process
1540 GO:0009966 regulation of signal transduction
1554 GO:0044271 cellular nitrogen compound biosynthetic process
1554 GO:0031324 negative regulation of cellular metabolic process
1554 GO:0010605 negative regulation of macromolecule metabolic process
1554 GO:0006468 protein phosphorylation
1554 GO:2000112 regulation of cellular macromolecule biosynthetic process
1554 GO:0032268 regulation of cellular protein metabolic process
1554 GO:0010468 regulation of gene expression
1623 GO:0007166 cell surface receptor signaling pathway
1623 GO:0006464 cellular protein modification process
1623 GO:0070887 cellular response to chemical stimulus
1623 GO:0035556 intracellular signal transduction
1623 GO:0031324 negative regulation of cellular metabolic process
1623 GO:0031325 positive regulation of cellular metabolic process
1623 GO:0010604 positive regulation of macromolecule metabolic process
1623 GO:0051173 positive regulation of nitrogen compound metabolic process
1623 GO:0051246 regulation of protein metabolic process
1623 GO:0009966 regulation of signal transduction
1623 GO:0006355 regulation of transcription, DNA-templated
1675 GO:0034645 cellular macromolecule biosynthetic process
1675 GO:0044271 cellular nitrogen compound biosynthetic process
1675 GO:0010467 gene expression
1683 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1683 GO:0031325 positive regulation of cellular metabolic process
1683 GO:0010604 positive regulation of macromolecule metabolic process
1683 GO:0051173 positive regulation of nitrogen compound metabolic process
1715 GO:0031324 negative regulation of cellular metabolic process
1715 GO:0010605 negative regulation of macromolecule metabolic process
1715 GO:0051172 negative regulation of nitrogen compound metabolic process
1715 GO:0010628 positive regulation of gene expression
1715 GO:0042981 regulation of apoptotic process
1715 GO:0032268 regulation of cellular protein metabolic process
1715 GO:0009966 regulation of signal transduction
1715 GO:0006355 regulation of transcription, DNA-templated
1716 GO:0044267 cellular protein metabolic process
1716 GO:0031324 negative regulation of cellular metabolic process
1716 GO:0010605 negative regulation of macromolecule metabolic process
1716 GO:0051172 negative regulation of nitrogen compound metabolic process
1716 GO:0009966 regulation of signal transduction
1716 GO:0006355 regulation of transcription, DNA-templated
1717 GO:0034645 cellular macromolecule biosynthetic process
1717 GO:0044271 cellular nitrogen compound biosynthetic process
1717 GO:0044267 cellular protein metabolic process
1718 GO:2000112 regulation of cellular macromolecule biosynthetic process
1718 GO:0032268 regulation of cellular protein metabolic process
1718 GO:0010468 regulation of gene expression
1718 GO:0006412 translation
1784 GO:0044271 cellular nitrogen compound biosynthetic process
1784 GO:0006139 nucleobase-containing compound metabolic process
1784 GO:1901362 organic cyclic compound biosynthetic process
1910 GO:0006464 cellular protein modification process
1910 GO:0010604 positive regulation of macromolecule metabolic process
1910 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
1910 GO:0010646 regulation of cell communication
1910 GO:0023051 regulation of signaling
1910 GO:0006355 regulation of transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1462 GO:0005654 nucleoplasm
1526 GO:0005634 nucleus
1540 GO:0031981 nuclear lumen
1553 GO:0044421 extracellular region part
1554 GO:0031981 nuclear lumen
1623 GO:0005634 nucleus
1675 GO:0005829 cytosol
1675 GO:0005634 nucleus
1683 GO:0005654 nucleoplasm
1715 GO:0031981 nuclear lumen
1716 GO:0043232 intracellular non-membrane-bounded organelle
1716 GO:0044428 nuclear part
1717 GO:0005634 nucleus
1718 GO:0005829 cytosol
1718 GO:0043232 intracellular non-membrane-bounded organelle
1718 GO:0005634 nucleus
1910 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP
GO:0001541 ovarian follicle development IGI
GO:0001555 oocyte growth IEA
GO:0002074 extraocular skeletal muscle development ISO
GO:0006309 apoptotic DNA fragmentation ISO
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0007338 single fertilization IGI
GO:0008585 female gonad development IGI
GO:0019101 female somatic sex determination IMP
GO:0033686 positive regulation of luteinizing hormone secretion IGI
GO:0042703 menstruation ISS
GO:0043065 positive regulation of apoptotic process ISS
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
GO:0045892 negative regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI
GO:0046881 positive regulation of follicle-stimulating hormone secretion IGI
GO:0048048 embryonic eye morphogenesis IMP
GO:0060014 granulosa cell differentiation IMP
GO:0060065 uterus development IGI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0045171 intercellular bridge ISO
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9620855 Multistep signaling requirements for pituitary organogenesis in vivo.
12471206 Evolution and expression of FOXL2.
15059956 Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
15944199 Foxl2 is required for commitment to ovary differentiation.
16153597 Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.
19106105 FoxL2 and Smad3 coordinately regulate follistatin gene transcription.
19797124 Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha.
20005806 Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.
No results found.
Domain Name Domain ID Source
Fork_head_dom IPR001766 InterPro
TF_fork_head_CS_1 IPR018122 InterPro
TF_fork_head_CS_2 IPR030456 InterPro
WH-like_DNA-bd_sf IPR036388 InterPro
WH_DNA-bd_sf IPR036390 InterPro
Forkhead PF00250 Pfam
FORKHEAD PR00053 PRINTS
FORK_HEAD_1 PS00657 PROSITE
FORK_HEAD_2 PS00658 PROSITE
FORK_HEAD_3 PS50039 PROSITE
FH SM00339 SMART
SSF46785 SSF46785 SUPFAM
FH cd00059 CDD