Protein: O75330 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O75330 (Uniprot)	HMMR_HUMAN	HMMR	Hyaluronan mediated motility receptor	human	Yes

Protein Function

Uniprot: Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated more..

Dissimilar Functions Manual Curation

Function 1: Hyaluronan-binding protein with CD44-activating functions, controls signalling through RAS proteins. Condition: extracellular localisation.

Function 2: Mitotic spindle or centrosomal protein. Condition: nuclear localisation.

Publications (PMID): 18354082

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

Showing 1 to 2 of 2 entries

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Module ID (MoonGO)	GO ID (CC)	GO Name
190	GO:0005829	cytosol
190	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

Showing 1 to 2 of 2 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0010389	regulation of G2/M transition of mitotic cell cycle	TAS
GO:0030214	hyaluronan catabolic process	TAS

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Cellular Components

Showing 1 to 4 of 4 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0009986	cell surface	IEA
GO:0016020	membrane	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 1 of 1 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005829	cytosol	GO:0009986	cell surface	3.26e-22	6.81e-06

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All Protein Interactions

Showing 1 to 10 of 13 entries

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Interactor	Also a MoonDB EMF protein
ARY2_HUMAN	No
BACH1_HUMAN	No
CAD13_HUMAN	No
CE170_HUMAN	No
DCTN1_HUMAN	No
GREB1_HUMAN	No
IL24_HUMAN	No
ITIH5_HUMAN	No
MORN4_HUMAN	No
NIN_HUMAN	No

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Publications Associated

Showing 1 to 9 of 9 entries

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PMID	Article Title
8890751	The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains.
9601098	The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15372022	The DNA sequence and comparative analysis of human chromosome 5.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18669648	A quantitative atlas of mitotic phosphorylation.
21269460	Initial characterization of the human central proteome.
22666460	ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 7 of 7 entries

Search:

Domain Name	Domain ID	Source
HMMR_C	IPR031794	InterPro
HMMR_C	PF15908	Pfam
HMMR_N	IPR031787	InterPro
HMMR_N	PF15905	Pfam
IHABP	IPR026203	InterPro
JC5016	JC5016	PIR
PTHR18956	PTHR18956	PANTHER

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